Faculty Opinions recommendation of An integrated genomic analysis of human glioblastoma multiforme.

Author(s):  
David Louis
Science ◽  
2008 ◽  
Vol 321 (5897) ◽  
pp. 1807-1812 ◽  
Author(s):  
D. W. Parsons ◽  
S. Jones ◽  
X. Zhang ◽  
J. C.-H. Lin ◽  
R. J. Leary ◽  
...  

1971 ◽  
Vol 18 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Eiichi Tani ◽  
Toshio Ametani

2021 ◽  
Vol 22 (13) ◽  
pp. 6781
Author(s):  
Anna Kirstein ◽  
Daniela Schilling ◽  
Stephanie E. Combs ◽  
Thomas E. Schmid

Background: Treatment resistance of glioblastoma multiforme to chemo- and radiotherapy remains a challenge yet to overcome. In particular, the O6-methylguanine-DNA-methyltransferase (MGMT) promoter unmethylated patients have only little benefit from chemotherapy treatment using temozolomide since MGMT counteracts its therapeutic efficacy. Therefore, new treatment options in radiotherapy need to be developed to inhibit MGMT and increase radiotherapy response. Methods: Lomeguatrib, a highly specific MGMT inhibitor, was used to inactivate MGMT protein in vitro. Radiosensitivity of established human glioblastoma multiforme cell lines in combination with lomeguatrib was investigated using the clonogenic survival assay. Inhibition of MGMT was analyzed using Western Blot. Cell cycle distribution and apoptosis were investigated to determine the effects of lomeguatrib alone as well as in combination with ionizing radiation. Results: Lomeguatrib significantly decreased MGMT protein and reduced radiation-induced G2/M arrest. A radiosensitizing effect of lomeguatrib was observed when administered at 1 µM and increased radioresistance at 20 µM. Conclusion: Low concentrations of lomeguatrib elicit radiosensitization, while high concentrations mediate a radioprotective effect.


2015 ◽  
Vol 35 (5) ◽  
pp. 1333-1340 ◽  
Author(s):  
LAIZANG WANG ◽  
ZHI WANG ◽  
JIANHUA LI ◽  
WEIGUANG ZHANG ◽  
FUBIN REN ◽  
...  

1995 ◽  
Vol 83 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Se Hyuck Park ◽  
Tatsuhiro Maeda ◽  
Gayatry Mohapatra ◽  
Frederic M. Waldman ◽  
Richard L. Davis ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document