Faculty Opinions recommendation of Influence of loop electrosurgical excision procedure on subsequent acquisition of new human papillomavirus infections.

Cervical intraepithelial neoplasia (CIN) is a precancerous lesion of cervical malignant tumors. CIN is closely related to persistent human papillomavirus (HPV) infection, sexual behavior, and number of childbirths. The effect of vaginal microbial metabolites (VMM) on CIN is unclear; hence, we studied the effects of VMM and high-risk HPV (HR-HPV) infection on CIN and the clinical effects of nano-silver after loop electrosurgical excision procedure (LEEP). We selected the patients who went to the obstetrics and gynecology department of our hospital from January 2019 to November 2020, and we conducted vaginal microbiology, HPV typing, and histopathological examination on 282 patients. Among them, six patients had cervical cancer, 136 patients with CIN were regarded as the CIN group, and 140 patients with normal pathological tissue were regarded as the normal group. The results showed that H2O2 and HR-HPV infection were significantly correlated with the risk of CIN (P < 0.05). LEEP was performed on CIN patients, and the treatment with nano-silver gynecological antibacterial suppository was postoperatively compared with patients without special treatment. The results show that postoperative treatment with nano-silver can shorten the bleeding and exudation time of the wound and promote wound healing. It can simultaneously reduce wound infection and promote HPV to become negative, which can effectively reduce postoperative complications and recurrence.

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Persistence of human papillomavirus as a predictor for treatment failure after loop electrosurgical excision procedure

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2007.00945.x ◽

2007 ◽

Vol 17 (6) ◽

pp. 1271-1277 ◽

Cited By ~ 35

Author(s):

J. H. Bae ◽

C. J. Kim ◽

T. C. Park ◽

S. E. Namkoong ◽

J. S. Park

Keyword(s):

Human Papillomavirus ◽

Treatment Failure ◽

Significant Risk ◽

Hpv Infection ◽

Dna Chip ◽

Hpv Dna ◽

Hpv Test ◽

Loop Electrosurgical Excision ◽

Loop Electrosurgical Excision Procedure

We aimed to investigate whether postconization human papillomavirus (HPV) DNA testing can predict treatment failure and improve the accuracy of conventional follow-up in women with high-grade cervical intraepithelial neoplasia (CIN). Between March 2001 and October 2005, 120 patients with confirmed CIN 2 or 3 were treated with loop electrosurgical excision procedure (LEEP) and were enrolled. Six patients were lost to the follow-up. Postconization follow-up was performed at every 3–6 months during the first year and then annually. Specimens were tested for the presence of HPV, using the Hybrid Capture 2 (Digene Co, Gaithersburg, MD) and HPV DNA chip (Mygene Co, Seoul, Korea) test. Persistent HPV infection was defined as persistently (two times or more) positive HPV tests with the same HPV subtype(s) at initial diagnosis. Twenty-two (19.3%) patients showed treatment failure after conization. The only significant risk factor for redevelopment of CIN after conization was persistence of the same HPV subtype (P< 0.0001). And women with recurrent or residual CIN had higher HPV load during the 6-month follow-up postconization. In conclusion, the persistence of the same HPV subtype after LEEP conization was an important predictor of treatment failure. The follow-up protocol after conization of CIN should include both cervical cytology and HPV test, and HPV DNA chip test is needed to detect a persistent HPV infection.

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