Faculty Opinions recommendation of [CONFERENCE POSTER]: Temporal dynamics of neuronal activity in macaque medial temporal lobe during a temporal order memory task.

2009 ◽  
Author(s):  
Howard Eichenbaum
Keyword(s):  
Temporal Lobe ◽  
Neuronal Activity ◽  
Medial Temporal Lobe ◽  
Temporal Order ◽  
Temporal Dynamics ◽  
Memory Task ◽  
Temporal Order Memory

scholarly journals Contributions of primate prefrontal cortex and medial temporal lobe to temporal-order memory

2017 ◽  
Vol 114 (51) ◽  
pp. 13555-13560 ◽  
Author(s):  
Yuji Naya ◽  
He Chen ◽  
Cen Yang ◽  
Wendy A. Suzuki
Keyword(s):  
Prefrontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Temporal Order ◽  
Temporal Dynamics ◽  
Memory Task ◽  
Multiple Time ◽  
Neurophysiological Studies ◽  
Time Periods ◽  
Temporal Order Memory

Neuropsychological and neurophysiological studies have emphasized the role of the prefrontal cortex (PFC) in maintaining information about the temporal order of events or items for upcoming actions. However, the medial temporal lobe (MTL) has also been considered critical to bind individual events or items to their temporal context in episodic memory. Here we characterize the contributions of these brain areas by comparing single-unit activity in the dorsal and ventral regions of macaque lateral PFC (d-PFC and v-PFC) with activity in MTL areas including the hippocampus (HPC), entorhinal cortex, and perirhinal cortex (PRC) as well as in area TE during the encoding phase of a temporal-order memory task. The v-PFC cells signaled specific items at particular time periods of the task. By contrast, MTL cortical cells signaled specific items across multiple time periods and discriminated the items between time periods by modulating their firing rates. Analysis of the temporal dynamics of these signals showed that the conjunctive signal of item and temporal-order information in PRC developed earlier than that seen in v-PFC. During the delay interval between the two cue stimuli, while v-PFC provided prominent stimulus-selective delay activity, MTL areas did not. Both regions of PFC and HPC exhibited an incremental timing signal that appeared to represent the continuous passage of time during the encoding phase. However, the incremental timing signal in HPC was more prominent than that observed in PFC. These results suggest that PFC and MTL contribute to the encoding of the integration of item and timing information in distinct ways.

Temporal order memory deficits prior to clinical diagnosis in Huntington’s disease

2009 ◽  
Vol 15 (5) ◽  
pp. 662-670 ◽  
Author(s):  
EVA PIROGOVSKY ◽  
JODY GOLDSTEIN ◽  
GUERRY PEAVY ◽  
MARK W. JACOBSON ◽  
JODY COREY-BLOOM ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Clinical Diagnosis ◽  
Temporal Order ◽  
Random Sequence ◽  
Memory Task ◽  
Study Phase ◽  
Phase Sequence ◽  
Choice Phase ◽  
Temporal Order Memory

AbstractThe current study examined temporal order memory in preclinical Huntington’s disease (pre-HD). Participants were separated into less than 5 years (pre-HD near) and more than 5 years (pre-HD far) from estimated age of clinical diagnosis. Participants completed a temporal order memory task on a computerized radial eight-arm maze. On the study phase of each trial, participants viewed a random sequence of circles appearing one at a time at the end of each arm. On the choice phase, participants viewed two circles at the end of the study phase arms and chose the circle occurring earliest in the sequence. The task involved manipulations of the temporal lag, defined as the number of arms occurring in the sample phase sequence between the two choice phase arms. Research suggests that there is more interference for temporally proximal stimuli relative to temporally distal stimuli. There were no significant differences between the pre-HD far group and controls on the temporal order memory task. The pre-HD near group demonstrated significant impairments relative to the other groups on closer temporal lags, but were normal on the furthest temporal lag. Therefore, temporal order memory declines with increased temporal interference in pre-HD close to estimated diagnosis of HD. (JINS, 2009, 15, 662–670.)

Phase/amplitude reset and theta-gamma interaction in the human medial temporal lobe during a continuous word recognition memory task

Hippocampus ◽  
2005 ◽  
Vol 15 (7) ◽  
pp. 890-900 ◽  
Author(s):  
Florian Mormann ◽  
Juergen Fell ◽  
Nikolai Axmacher ◽  
Bernd Weber ◽  
Klaus Lehnertz ◽  
...  
Keyword(s):  
Word Recognition ◽  
Recognition Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Task ◽  
Recognition Memory Task ◽  
Phase Amplitude

NEURONAL ACTIVITY IN THE HUMAN MEDIAL TEMPORAL LOBE DURING RECOGNITION MEMORY

Brain ◽  
1990 ◽  
Vol 113 (4) ◽  
pp. 1093-1112 ◽  
Author(s):  
GARY HEIT ◽  
MICHAEL E. SMITH ◽  
ERIC HALGREN
Keyword(s):  
Recognition Memory ◽  
Temporal Lobe ◽  
Neuronal Activity ◽  
Medial Temporal Lobe

A Neuroanatomical Construct for the Amnesic Effects of Propofol

2002 ◽  
Vol 97 (2) ◽  
pp. 329-337 ◽  
Author(s):  
Robert A. Veselis ◽  
Ruth A. Reinsel ◽  
Vladimir A. Feshchenko ◽  
Ann M. Dnistrian
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Regional Cerebral Blood Flow ◽  
Memory Task ◽  
Statistical Parametric Mapping ◽  
Regional Cerebral Blood ◽  
Word Memory

Background This study was designed to identify neuroanatomical locations of propofol's effects on episodic memory by producing minimal and maximal memory impairment during conscious sedation. Drug-related changes in regional cerebral blood flow (rCBF) were located in comparison with rCBF increases during a simple word memory task. Methods Regional cerebral blood flow changes were assessed in 11 healthy volunteers using H215O positron emission tomography (PET) and statistical parametric mapping (SPM99) at 600 and 1,000 ng/ml propofol target concentrations. Study groups were based on final recognition scores of auditory words memorized during PET scanning. rCBF changes during propofol administration were compared with those during the word memory task at baseline. Results Nonoverlapping memory effects were evident: low (n = 4; propofol concentration 523 +/- 138 ng/ml; 44 +/- 13% decrement from baseline memory) and high (n = 7; 829 +/- 246 ng/ml; 87 +/- 6% decrement from baseline) groups differed in rCBF reductions primarily in right-sided prefrontal and parietal regions, close to areas activated in the baseline memory task, particularly R dorsolateral prefrontal cortex (Brodmann area 46; x, y, z = 51, 38, 22). The medial temporal lobe region exhibited relative rCBF increases. Conclusions As amnesia becomes maximal, rCBF reductions induced by propofol occur in brain regions identified with working memory processes. In contrast, medial temporal lobe structures were resistant to the global CBF decrease associated with propofol sedation. The authors postulate that the episodic memory effect of propofol is produced by interference with distributed cortical processes necessary for normal memory function rather than specific effects on medial temporal lobe structures.

scholarly journals Medial temporal lobe activity at recognition increases with the duration of mnemonic delay during an object working memory task

2007 ◽  
Vol 28 (11) ◽  
pp. 1235-1250 ◽  
Author(s):  
Marco Picchioni ◽  
Pall Matthiasson ◽  
Matthew Broome ◽  
Vincent Giampietro ◽  
Mick Brammer ◽  
...  
Keyword(s):  
Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Task
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