Faculty Opinions recommendation of Short-term facilitation modulates size and timing of the synaptic response at the inner hair cell ribbon synapse.

2011 ◽  
Author(s):  
Tobias Moser ◽  
Regis Nouvian
Keyword(s):  
Hair Cell ◽  
Ribbon Synapse ◽  
Synaptic Response ◽  
Inner Hair Cell ◽  
Short Term

scholarly journals The Role of Mobile Calcium Buffers in Synaptic Transmission at the Inner Hair Cell Ribbon Synapse

2012 ◽  
Vol 102 (3) ◽  
pp. 319a
Author(s):  
Tina Pangrsic ◽  
Nicola Strenzke ◽  
Beat Schwaller ◽  
Tobias Moser
Keyword(s):  
Synaptic Transmission ◽  
Hair Cell ◽  
Ribbon Synapse ◽  
Inner Hair Cell ◽  
Calcium Buffers

Insulin resistance due to dietary iron overload disrupts inner hair cell ribbon synapse plasticity in male mice

2015 ◽  
Vol 597 ◽  
pp. 183-188 ◽  
Author(s):  
Fei Yu ◽  
Shuai Hao ◽  
Bo Yang ◽  
Yue Zhao ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Iron Overload ◽  
Hair Cell ◽  
Ribbon Synapse ◽  
Dietary Iron ◽  
Male Mice ◽  
Inner Hair Cell ◽  
Synapse Plasticity

scholarly journals Excess extracellular K+ causes inner hair cell ribbon synapse degeneration

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Hong-Bo Zhao ◽  
Yan Zhu ◽  
Li-Man Liu
Keyword(s):  
Hair Cell ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Bk Channel ◽  
Ribbon Synapse ◽  
Channel Blockers ◽  
Inner Hair Cell ◽  
Ribbon Synapses ◽  
Synapse Degeneration ◽  
Hidden Hearing Loss

AbstractInner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy remains unclear. Here, we report that elevation of extracellular K+, which is a consequence of noise exposure, could cause IHC ribbon synapse degeneration and swelling. Like intensity dependence in noise-induced cochlear synaptopathy, the K+-induced degeneration was dose-dependent, and could be attenuated by BK channel blockers. However, application of glutamate receptor (GluR) agonists caused ribbon swelling but not degeneration. In addition, consistent with synaptopathy in HHL, both K+ and noise exposure only caused IHC but not outer hair cell ribbon synapse degeneration. These data reveal that K+ excitotoxicity can degenerate IHC ribbon synapses in HHL, and suggest that BK channel may be a potential target for prevention and treatment of HHL.

scholarly journals Two Photon Imaging of Calcium Signalling at the Mouse Inner Hair Cell Ribbon Synapse

2010 ◽  
Vol 98 (3) ◽  
pp. 508a
Author(s):  
Jonathan F. Ashmore ◽  
Siân Culley ◽  
Jacques Boutet de Monvel ◽  
Christine Petit ◽  
Said Safieddine
Keyword(s):  
Hair Cell ◽  
Calcium Signalling ◽  
Ribbon Synapse ◽  
Inner Hair Cell ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging
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