Faculty Opinions recommendation of Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.

2010 ◽  
Author(s):  
Richard Grencis
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Helminth Infection ◽  
Cutting Edge ◽  
Th2 Immunity ◽  
Draining Lymph Nodes

scholarly journals Cutting Edge: Tumor-Specific CTL Are Constitutively Cross-Armed in Draining Lymph Nodes and Transiently Disseminate to Mediate Tumor Regression following Systemic CD40 Activation

2004 ◽  
Vol 173 (10) ◽  
pp. 5923-5928 ◽  
Author(s):  
Philip A. Stumbles ◽  
Robyn Himbeck ◽  
Jeffrey A. Frelinger ◽  
Edward J. Collins ◽  
Richard A. Lake ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Tumor Regression ◽  
Cutting Edge ◽  
Cd40 Activation ◽  
Draining Lymph Nodes

Increased activity of lymph node cells in experimental thermal injury: changes in accessory cells in injured area-draining lymph nodes

Burns ◽  
2000 ◽  
Vol 26 (6) ◽  
pp. 525-534 ◽  
Author(s):  
Milena Kataranovski ◽  
Tatjana Nikolić ◽  
Maja Veličković ◽  
Miodrag Čolić ◽  
Nada Pejnović ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Thermal Injury ◽  
Injured Area ◽  
Accessory Cells ◽  
Lymph Node Cells ◽  
Increased Activity ◽  
Draining Lymph Nodes

scholarly journals ICOS Costimulation Expands Th2 Immunity by Augmenting Migration of Lymphocytes to Draining Lymph Nodes

2008 ◽  
Vol 181 (2) ◽  
pp. 1019-1024 ◽  
Author(s):  
Amanda G. Tesciuba ◽  
Rebecca A. Shilling ◽  
Monica D. Agarwal ◽  
Hozefa S. Bandukwala ◽  
Bryan S. Clay ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Th2 Immunity ◽  
Draining Lymph Nodes

scholarly journals Intramuscular Inoculation of Mice with the Live-Attenuated Recombinant Rabies Virus TriGAS Results in a Transient Infection of the Draining Lymph Nodes and a Robust, Long-Lasting Protective Immune Response against Rabies

2012 ◽  
Vol 87 (3) ◽  
pp. 1834-1841 ◽  
Author(s):  
Keith Schutsky ◽  
Dana Curtis ◽  
Emily K. Bongiorno ◽  
Darryll A. Barkhouse ◽  
Rhonda B. Kean ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Rabies Virus ◽  
Neutralizing Antibodies ◽  
Lethal Dose ◽  
Genomic Rna ◽  
Qpcr Analysis ◽  
Copy Numbers ◽  
Draining Lymph Nodes

ABSTRACTA single intramuscular application of the live but not UV-inactivated recombinant rabies virus (RABV) variant TriGAS in mice induces the robust and sustained production of RABV-neutralizing antibodies that correlate with long-term protection against challenge with an otherwise lethal dose of the wild-type RABV. To obtain insight into the mechanism by which live TriGAS induces long-lasting protective immunity, quantitative PCR (qPCR) analysis of muscle tissue, draining lymph nodes, spleen, spinal cord, and brain at different times after TriGAS inoculation revealed the presence of significant copy numbers of RABV-specific RNA in muscle, lymph node, and to a lesser extent, spleen for several days postinfection. Notably, no significant amounts of RABV RNA were detected in brain or spinal cord at any time after TriGAS inoculation. Differential qPCR analysis revealed that the RABV-specific RNA detected in muscle is predominantly genomic RNA, whereas RABV RNA detected in draining lymph nodes is predominantly mRNA. Comparison of genomic RNA and mRNA obtained from isolated lymph node cells showed the highest mRNA-to-genomic-RNA ratios in B cells and dendritic cells (DCs), suggesting that these cells represent the major cell population that is infected in the lymph node. Since RABV RNA declined to undetectable levels by 14 days postinoculation of TriGAS, we speculate that a transient infection of DCs with TriGAS may be highly immunostimulatory through mechanisms that enhance antigen presentation. Our results support the superior efficacy and safety of TriGAS and advocate for its utility as a vaccine.

Sign in / Sign up

Export Citation Format

Share Document