Faculty Opinions recommendation of Mannose-binding lectin and the risk of HIV transmission and disease progression in children: a systematic review.

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M S Longhi ◽  
N J Taylor ◽  
A Gera ◽  
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...  

Mannose-binding lectin (MBL) plays a key role in the human innate immune response. It has been shown that polymorphisms in theMBL2gene, particularly at codon 54 (variant alleleB; wild-type allele designated asA), impact upon host susceptibility toCandidainfection. This systematic review and meta-analysis were performed to assess the association betweenMBL2codon 54 genotype and vulvovaginal candidiasis (VVC) or recurrent VVC (RVVC). Studies were searched in MEDLINE, SCOPUS, and ISI Web of Science until April 2013. Five studies including 704 women (386 cases and 318 controls) were part of the meta-analysis, and pooled ORs were calculated using the random effects model. For subjects with RVVC, ORs ofABversusAAand ofBBversusAAwere 4.84 (95% CI 2.10–11.15;Pfor heterogeneity=0.013;I2=68.6%) and 12.68 (95% CI 3.74–42.92;Pfor heterogeneity=0.932,I2=0.0%), respectively. For subjects with VVC, OR ofABversusAAwas 2.57 (95% CI 1.29–5.12;Pfor heterogeneity=0.897;I2=0.0%). This analysis indicates that heterozygosity for theMBL2alleleBincreases significantly the risk for both diseases, suggesting that MBL may influence the women’s innate immunity in response toCandida.


2021 ◽  
pp. 104945
Author(s):  
Rodrigo Feliciano do Carmo ◽  
Jaime Rangel Leal Neves ◽  
Pablo Rafael Silveira Oliveira ◽  
Luydson Richardson Silva Vasconcelos ◽  
Carlos Dornels Freire de Souza

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