Faculty Opinions recommendation of Obesity, assisted reproductive technology, and early preterm birth--Florida, 2004-2006.

Objective. Assisted reproductive technology (ART)-treated women exhibit increased risk of premature delivery compared to fertile women. We evaluated whether ART treatment modalities increase prematurity and whether placental abnormalities and pregnancy-induced hypertensive (PIH) disorders mediate these risks. Method(s): This retrospective study of ART-treated and fertile deliveries (2004–2017) used an ART-cycle database linked to Massachusetts birth certificates and hospital discharges. Outcomes of late preterm birth (LPTB: 34–36 weeks gestation) and early preterm birth (EPTB: <34 weeks gestation) were compared with term deliveries (≥37 weeks gestation) in ART-treated (linked to the ART database) and fertile (no indicators of infertility or ART) deliveries. ART treatments with autologous oocyte, donor oocyte, fresh or frozen embryo transfer (FET), intracytoplasmic sperm injection (ICSI) and no-ICSI were separately compared to the fertile group. Adjusted odds ratios (AOR) were calculated with multivariable logistic regression: placental abnormalities or PIH were quantified in the pathway as mediators. Results: There were 218,320 deliveries: 204,438 fertile and 13,882 ART-treated. All treatment types increased prematurity (AOR 1.31–1.58, LPTB; AOR 1.34–1.48, EPTB). Placental abnormalities mediated in approximately 22% and 38% of the association with LPTB and EPTB, respectively. PIH mediated 25% and 33% of the association with LPTB and EPTB in FET and donor oocyte cycles, more than other treatments (<10% LPTB and <13% EPTB). Conclusions: ART-treatment and all ART modalities increased LPTB and EPTB when compared with fertile deliveries. Placental abnormalities modestly mediated associations approximately equally, while PIH was a stronger mediator in FET and donor oocyte cycles. Reasons for differences require exploration.

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Endometrial endotoxin, assisted reproductive technology, and preterm birth

Fertility and Sterility ◽

10.1016/j.fertnstert.2004.04.036 ◽

2004 ◽

Vol 82 (4) ◽

pp. 793-794

Author(s):

J IAMS

Keyword(s):

Preterm Birth ◽

Assisted Reproductive Technology ◽

Reproductive Technology

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A Clinical Nomogram For Predicting Preterm Birth in Women Who Conceived Through Assisted Reproductive Technology

10.21203/rs.3.rs-1036505/v1 ◽

2021 ◽

Author(s):

Yaduan Lin ◽

Fanchen He ◽

Rui Gao ◽

Ting Liu ◽

Ke Zhao ◽

...

Keyword(s):

Preterm Birth ◽

Assisted Reproductive Technology ◽

Risk Model ◽

Cox Regression ◽

Early Stage ◽

Statistical Significance ◽

Reproductive Technology ◽

Brier Score ◽

Chronic Hypertension ◽

Singleton Pregnancy

Abstract Background: We used prepregnant and gestational characteristics as predictors to develop and validated a nomogram predicting the risk of preterm birth (PTB) in assisted reproductive technology (ART) treated women. Methods: The National Vital Statistics System (NVSS) was queried for singleton ART-treated pregnant women from 2015 to 2019. Multivariable cox regression was used to develop the early (< 32 weeks) or late (< 37 weeks) PTB risk model using both statistical significance and clinical importance criteria for variable selection. The predictive accuracy was assessed, and bootstrapping was used for validation. A nomogram was constructed for the presentation of the final model. Results: ART-treated women who were over 45 years old, black, obese, had a history of cesarean section and PTB, restarting ART within 3 months, prepregnant diabetes, chronic hypertension, gestational diabetes, gestational hypertension, and eclampsia, had the highest risk for late and early-stage PTB. The nomogram with these variables accurately predicted PTB in ART women with a singleton pregnancy. (Brier score:0.121, calibration slope: 0.99, c-index: 0.684). Conclusion: We created a nomogram predicting the risk of early or late PTB in ART women with a singleton pregnancy, which could identify potentially at-risk women who seeking ART treatment and inform appropriate preterm care.

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Preterm Birth in Assisted Reproductive Technology: An Analysis of More Than 20,000 Singleton Newborns

Frontiers in Endocrinology ◽

10.3389/fendo.2020.558819 ◽

2020 ◽

Vol 11 ◽

Author(s):

Zhiqin Bu ◽

Jiaxin Zhang ◽

Linli Hu ◽

Yingpu Sun

Keyword(s):

Preterm Birth ◽

Assisted Reproductive Technology ◽

Reproductive Technology

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Singleton Preterm Birth: Risk Factors and Association with Assisted Reproductive Technology

Maternal and Child Health Journal ◽

10.1007/s10995-011-0787-8 ◽

2011 ◽

Vol 16 (4) ◽

pp. 807-813 ◽

Cited By ~ 20

Author(s):

Naomi K. Tepper ◽

Sherry L. Farr ◽

Bruce B. Cohen ◽

Angela Nannini ◽

Zi Zhang ◽

...

Keyword(s):

Risk Factors ◽

Preterm Birth ◽

Assisted Reproductive Technology ◽

Reproductive Technology

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Preterm birth and Assisted Reproductive Technology/ART: Maternal emotional wellbeing and quality of mother–newborn interaction during the first three months of life

Early Human Development ◽

10.1016/j.earlhumdev.2011.10.003 ◽

2012 ◽

Vol 88 (6) ◽

pp. 397-402 ◽

Cited By ~ 4

Author(s):

Maria A. Tallandini ◽

Valentina Morsan ◽

Franco Macagno

Keyword(s):

Preterm Birth ◽

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Emotional Wellbeing

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1332Endometriosis, assisted reproductive technology and adverse pregnancy outcomes: a population based data linkage study

International Journal of Epidemiology ◽

10.1093/ije/dyab168.302 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Ibinabo Ibiebele ◽

Tanya Nippita ◽

Rodney Baber ◽

Siranda Torvaldsen

Keyword(s):

Preterm Birth ◽

Assisted Reproductive Technology ◽

Pregnancy Outcomes ◽

Data Linkage ◽

Reproductive Technology ◽

Linkage Study ◽

Adverse Pregnancy Outcomes ◽

Placenta Praevia ◽

Antepartum Haemorrhage ◽

Adverse Pregnancy

Abstract Background Endometriosis is a chronic inflammatory disease characterised by endometrial tissue outside the uterus – pain and infertility are common symptoms. There is a paucity of data on the association between endometriosis and adverse pregnancy outcomes where the contribution of assisted reproductive technology (ART) use is also considered. This study will examine the association between endometriosis, with and without ART use, on adverse pregnancy outcomes. Methods Population data linkage study of all female NSW residents aged 15-45 years with a singleton birth in 2006-2015. Pregnancies were classified into 4 groups based on endometriosis diagnosis (yes/no) and ART use (yes/no). Multinomial logistic regression was used to estimate the odds of adverse pregnancy outcomes with 99% confidence intervals, adjusting for maternal and pregnancy factors. Outcomes assessed included placenta praevia, antepartum haemorrhage, planned birth (induction of labour or caesarean section) and preterm birth. Results Of 889,101 eligible pregnancies, women with endometriosis were more likely to be older while women who used ART were more likely to be nulliparous, birth in a private hospital and less likely to smoke. Adjusted odds ratios for selected study outcomes are outlined below. Conclusions Endometriosis is associated with increased odds of preterm birth, placenta praevia, antepartum haemorrhage and planned birth. In general, the odds of adverse pregnancy outcomes associated with endometriosis were further increased with ART use. Key messages These findings suggest that women with endometriosis, especially those who achieved pregnancy via ART use, represent a high risk obstetric population requiring appropriate surveillance and management.

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