scholarly journals Influence of Placental Abnormalities and Pregnancy-Induced Hypertension in Prematurity Associated with Various Assisted Reproductive Technology Techniques

2021 ◽  
Vol 10 (8) ◽  
pp. 1681
Author(s):  
Judy E. Stern ◽  
Chia-ling Liu ◽  
Sunah S. Hwang ◽  
Dmitry Dukhovny ◽  
Leslie V. Farland ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Treatment Modalities ◽  
Birth Certificates ◽  
Premature Delivery ◽  
Hospital Discharges ◽  
Donor Oocyte ◽  
Increased Risk ◽  
Early Preterm Birth

Objective. Assisted reproductive technology (ART)-treated women exhibit increased risk of premature delivery compared to fertile women. We evaluated whether ART treatment modalities increase prematurity and whether placental abnormalities and pregnancy-induced hypertensive (PIH) disorders mediate these risks. Method(s): This retrospective study of ART-treated and fertile deliveries (2004–2017) used an ART-cycle database linked to Massachusetts birth certificates and hospital discharges. Outcomes of late preterm birth (LPTB: 34–36 weeks gestation) and early preterm birth (EPTB: <34 weeks gestation) were compared with term deliveries (≥37 weeks gestation) in ART-treated (linked to the ART database) and fertile (no indicators of infertility or ART) deliveries. ART treatments with autologous oocyte, donor oocyte, fresh or frozen embryo transfer (FET), intracytoplasmic sperm injection (ICSI) and no-ICSI were separately compared to the fertile group. Adjusted odds ratios (AOR) were calculated with multivariable logistic regression: placental abnormalities or PIH were quantified in the pathway as mediators. Results: There were 218,320 deliveries: 204,438 fertile and 13,882 ART-treated. All treatment types increased prematurity (AOR 1.31–1.58, LPTB; AOR 1.34–1.48, EPTB). Placental abnormalities mediated in approximately 22% and 38% of the association with LPTB and EPTB, respectively. PIH mediated 25% and 33% of the association with LPTB and EPTB in FET and donor oocyte cycles, more than other treatments (<10% LPTB and <13% EPTB). Conclusions: ART-treatment and all ART modalities increased LPTB and EPTB when compared with fertile deliveries. Placental abnormalities modestly mediated associations approximately equally, while PIH was a stronger mediator in FET and donor oocyte cycles. Reasons for differences require exploration.

scholarly journals Risk factors vary early preterm birth and perinatal complications after assisted reproductive technology

2016 ◽  
Vol 32 (sup2) ◽  
pp. 56-61 ◽  
Author(s):  
G. Chistyakova ◽  
I. Gazieva ◽  
I. Remizova ◽  
L. Ustyantseva ◽  
V. Lyapunov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Perinatal Complications ◽  
Early Preterm Birth

Obesity, Assisted Reproductive Technology, and Early Preterm Birth--Florida, 2004-2006

2012 ◽  
Vol 176 (10) ◽  
pp. 886-896 ◽  
Author(s):  
E. K. Sauber-Schatz ◽  
W. Sappenfield ◽  
V. Grigorescu ◽  
A. Kulkarni ◽  
Y. Zhang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Early Preterm Birth

scholarly journals Assisted reproductive technology is not associated with an increased risk of pediatric cancer

2018 ◽  
Vol 110 (4) ◽  
pp. e16-e17 ◽  
Author(s):  
D. Gilboa ◽  
G. Koren ◽  
R. Katz ◽  
R. Rotem ◽  
E. Lunenfeld
Keyword(s):  
Assisted Reproductive Technology ◽  
Pediatric Cancer ◽  
Reproductive Technology ◽  
Increased Risk

A Clinical Nomogram For Predicting Preterm Birth in Women Who Conceived Through Assisted Reproductive Technology

2021 ◽  
Author(s):  
Yaduan Lin ◽  
Fanchen He ◽  
Rui Gao ◽  
Ting Liu ◽  
Ke Zhao ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Assisted Reproductive Technology ◽  
Risk Model ◽  
Cox Regression ◽  
Early Stage ◽  
Statistical Significance ◽  
Reproductive Technology ◽  
Brier Score ◽  
Chronic Hypertension ◽  
Singleton Pregnancy

Abstract Background: We used prepregnant and gestational characteristics as predictors to develop and validated a nomogram predicting the risk of preterm birth (PTB) in assisted reproductive technology (ART) treated women. Methods: The National Vital Statistics System (NVSS) was queried for singleton ART-treated pregnant women from 2015 to 2019. Multivariable cox regression was used to develop the early (< 32 weeks) or late (< 37 weeks) PTB risk model using both statistical significance and clinical importance criteria for variable selection. The predictive accuracy was assessed, and bootstrapping was used for validation. A nomogram was constructed for the presentation of the final model. Results: ART-treated women who were over 45 years old, black, obese, had a history of cesarean section and PTB, restarting ART within 3 months, prepregnant diabetes, chronic hypertension, gestational diabetes, gestational hypertension, and eclampsia, had the highest risk for late and early-stage PTB. The nomogram with these variables accurately predicted PTB in ART women with a singleton pregnancy. (Brier score:0.121, calibration slope: 0.99, c-index: 0.684). Conclusion: We created a nomogram predicting the risk of early or late PTB in ART women with a singleton pregnancy, which could identify potentially at-risk women who seeking ART treatment and inform appropriate preterm care.

Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications

2018 ◽  
Vol 36 (03/04) ◽  
pp. 195-203
Author(s):  
Emre Seli ◽  
Scott Morin
Keyword(s):  
Assisted Reproductive Technology ◽  
Premature Birth ◽  
Absolute Risk ◽  
Reproductive Technology ◽  
Multiple Gestation ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Monogenic Disorder ◽  
Increased Risk ◽  
Confounding Variables

AbstractThe majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Furthermore, many studies fail to account for the increased risk of many of these pathologies in the offspring of subfertile women in general. Lastly, the absolute risk of most of the ailments studied is extremely low. In nearly all examples, the number of women who would need to be treated to observe one additional diagnosis is substantially high. When compared with the number of couples who would have remained childless due to severe male factor infertility or would have been exposed to the risk of passing on a severe monogenic disorder, the general increased risks to ART-exposed children is very small.

Sign in / Sign up

Export Citation Format

Share Document