Faculty Opinions recommendation of Muscle cramps in liver disease.

2014 ◽  
Author(s):  
Oren Fix
Keyword(s):  
Liver Disease ◽  
Muscle Cramps

Randomised clinical trial: oral taurine supplementation versus placebo reduces muscle cramps in patients with chronic liver disease

2018 ◽  
Vol 48 (7) ◽  
pp. 704-712 ◽  
Author(s):  
Helen Vidot ◽  
Erin Cvejic ◽  
Sharon Carey ◽  
Simone Irene Strasser ◽  
Geoffrey William McCaughan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Randomised Clinical Trial ◽  
Chronic Liver ◽  
Taurine Supplementation ◽  
Muscle Cramps

Overlooked muscle cramps in patients with chronic liver disease

2019 ◽  
Vol 31 (3) ◽  
pp. 375-381 ◽  
Author(s):  
Ai Murata ◽  
Hideyuki Hyogo ◽  
Michihiro Nonaka ◽  
Akihiko Sumioka ◽  
Yosuke Suehiro ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Muscle Cramps

scholarly journals Effect of Fermented Rice Drink “Amazake” on Patients with Nonalcoholic Fatty Liver Disease and Periodontal Disease: A Pilot Study

Reports ◽  
2021 ◽  
Vol 4 (4) ◽  
pp. 36
Author(s):  
Yumiko Nagao ◽  
Hirokazu Takahashi ◽  
Atsushi Kawaguchi ◽  
Hiroshi Kitagaki
Keyword(s):  
Liver Disease ◽  
Periodontal Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Rice Starch ◽  
Nonalcoholic Fatty Liver ◽  
Muscle Cramps ◽  
Periodontal Bacteria ◽  
Obesity And Diabetes

The worldwide increase in nonalcoholic fatty liver disease (NAFLD) is a major public health problem. Obesity and diabetes are risk factors for NAFLD and the development of liver fibrosis is a risk factor for liver cancer. Periodontal disease bacteria can also exacerbate NAFLD. We previously reported that amazake, a traditional Japanese fermented food, improves the quality of life (QOL) of patients with liver cirrhosis. In this study, we investigated the effect of amazake intake on NAFLD patients with periodontal disease. Ten patients (mean age: 57.1 ± 19.2 years) consumed 100 g of amazake daily for 60 days. On days 0 and 60, their body mass index (BMI), body fat percentage, serum biochemical parameters, periodontal disease bacteria in saliva, and ten visual analog scales (VASs), namely, sense of abdomen distension, edema, fatigue, muscle cramps, loss of appetite, taste disorder, constipation, diarrhea, depression, and sleep disorder, were measured. For periodontal bacteria, the numbers of six types of bacteria in saliva (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, and Fusobacterium necleatum) and P. gingivalis-specific fimA genotype were determined. After 60 days of amazake consumption, eosinophils (p < 0.05), immune reactive insulin (IRI) (p < 0.01), and HOMA-IR (p < 0.05) had significantly increased and tumor necrosis factor α (TNFα) (p < 0.01), muscle cramps (p < 0.05), and depression (p < 0.05) had significantly decreased. All subjective symptoms improved after amazake intake. No change was observed in the periodontal bacteria. In conclusion, amazake significantly decreased TNFα and improved the QOL of the patients with NAFLD and periodontitis. However, caution should be exercised because amazake, which is manufactured using techniques that lead to concentrations of glucose from the saccharification of rice starch, may worsen glucose metabolism in NAFLD patients. Amazake may be an effective food for improving the symptoms of a fatty liver if energy intake is regulated.

Muscle Cramps in Liver Disease

2013 ◽  
Vol 11 (11) ◽  
pp. 1385-1391 ◽  
Author(s):  
Shivang S. Mehta ◽  
Michael B. Fallon
Keyword(s):  
Liver Disease ◽  
Muscle Cramps

scholarly journals Muscle Cramps: A ‘Complication‘ of Cirrhosis

2000 ◽  
Vol 14 (suppl d) ◽  
pp. 21D-25D ◽  
Author(s):  
Paul J Marotta ◽  
Ivo W Graziadei ◽  
Cameron N Ghent
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Pathophysiological Mechanism ◽  
Therapeutic Approaches ◽  
Specific Therapy ◽  
Therapeutic Success ◽  
Pharmacological Agents ◽  
Muscle Cramps ◽  
Common Complaint ◽  
Electrolyte Abnormalities

Muscle cramps are a common complaint in clinical practice. They are associated with various metabolic, endocrine, neurological and electrolyte abnormalities. A variety of hypotheses have been generated to explain the cause of muscle cramping, yet none has been able to support a consistent pathophysiological mechanism. Muscle cramps are painful, involuntary contractions of skeletal muscle. They occur frequently in individuals with cirrhosis, regardless of the etiology, and are thought to be a symptom of cirrhotic-stage liver disease. The pathophysiology of these cramps remains elusive; hence, a specific therapy has not been identified. Many therapeutic approaches have been offered, yet their efficacy, safety and mechanism of action remain poorly defined. This review defines muscle cramps and illuminates its prevalence in the cirrhotic individual. Current theories relating to the pathogenesis of muscle cramps are reviewed, and an overview of the various pharmacological agents that have had therapeutic success for this distressing and frustrating symptom is provided.

scholarly journals Effect of Administration of Sairei-to on Painful Muscle Cramps in Patients with Chronic Liver Disease, Especially with Cirrhosis of the Liver.

1993 ◽  
Vol 43 (4) ◽  
pp. 539-544 ◽  
Author(s):  
Masahiro NAKAO ◽  
Tokan HIRANO ◽  
Sadahiko HIRATANI ◽  
Masayoshi FUJISAWA ◽  
Shinobu SAITO ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Cirrhosis Of The Liver ◽  
Muscle Cramps

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

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