Faculty Opinions recommendation of Levothyroxine treatment and pregnancy outcome in women with subclinical hypothyroidism undergoing assisted reproduction technologies: systematic review and meta-analysis of RCTs.

2013 ◽  
Author(s):  
Beverley Vollenhoven ◽  
Alon Talmor
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcome ◽  
Assisted Reproduction ◽  
Subclinical Hypothyroidism ◽  
Meta Analysis ◽  
Assisted Reproduction Technologies ◽  
Levothyroxine Treatment

scholarly journals Levothyroxine and the risk of adverse pregnancy outcomes in women with subclinical hypothyroidism: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Magnus Bein ◽  
Oriana Hoi Yun Yu ◽  
Sonia Marzia Grandi ◽  
Francesca Y. E. Frati ◽  
Ihab Kandil ◽  
...  
Keyword(s):  
Systematic Review ◽  
Subclinical Hypothyroidism ◽  
Pregnancy Outcomes ◽  
Neonatal Death ◽  
Observational Studies ◽  
Pregnancy Loss ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy ◽  
Levothyroxine Treatment

Abstract Background Levothyroxine replacement therapy may decrease the risk of adverse pregnancy outcomes among women with subclinical hypothyroidism (SCH). The aim of this study is to conduct a systematic review and meta-analysis to examine the risk of adverse pregnancy, perinatal, and early childhood outcomes among women with SCH treated with levothyroxine. Methods A systematic literature search was conducted using Ovid-Medline, Ovid-EMBASE, Pubmed (non-Medline), Ebsco-CINAHL Plus with full text and Cochrane Library databases. Randomized controlled studies (RCTs) and observational studies examining the association between treatment of SCH during pregnancy and our outcomes of interest were included. Studies that compared levothyroxine treatment versus no treatment were eligible for inclusion. Data from included studies were extracted and quality assessment was performed by two independent reviewers. Results Seven RCTs and six observational studies met our inclusion criteria. A total of 7342 individuals were included in these studies. RCTs demonstrated several sources of bias, with lack of blinding of the participants or research personnel; only one study was fully blinded. In the observational studies, there was moderate to serious risk of bias due to lack of adjustment for certain confounding variables, participant selection, and selective reporting of results. Pooled analyses showed decreased risk of pregnancy loss (RR: 0.79; 95% CI: 0.67 to 0.93) and neonatal death (RR: 0.35; 95% CI: 0.17 to 0.72) associated with levothyroxine treatment during pregnancy among women with SCH. There were no associations between levothyroxine treatment and outcomes during labour and delivery, or cognitive status in children at 3 or 5 years of age. Conclusion Treatment of SCH with levothyroxine during pregnancy is associated with decreased risks of pregnancy loss and neonatal death. Given the paucity of available data and heterogeneity of included studies, additional studies are needed to address the benefits of levothyroxine use among pregnant women with SCH.

scholarly journals Do women offered assisted reproduction technologies have a higher incidence of gynecologic cancer? A systematic review and meta-analysis

2017 ◽  
Vol 21 (2) ◽  
Author(s):  
Juan Enrique Schwarze ◽  
Paulina Valdebenito ◽  
Carolina Ortega ◽  
Sonia Villa ◽  
Javier Crosby ◽  
...  
Keyword(s):  
Systematic Review ◽  
Assisted Reproduction ◽  
Meta Analysis ◽  
Gynecologic Cancer ◽  
Assisted Reproduction Technologies

Levothyroxine treatment and pregnancy outcomes in women with subclinical hypothyroidism: a systematic review and meta-analysis

2019 ◽  
Vol 300 (4) ◽  
pp. 805-819 ◽  
Author(s):  
Sima Nazarpour ◽  
Fahimeh Ramezani Tehrani ◽  
Mina Amiri ◽  
Razieh Bidhendi Yarandi ◽  
Fereidoun Azizi
Keyword(s):  
Systematic Review ◽  
Subclinical Hypothyroidism ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Levothyroxine Treatment

scholarly journals Pregnancy outcome predictors in antiphospholipid syndrome: A systematic review and meta-analysis

2021 ◽  
pp. 102901
Author(s):  
Isabel Johanna Walter ◽  
Mirthe Jasmijn Klein Haneveld ◽  
Anne Titia Lely ◽  
Katharina Wilhelmina Maria Bloemenkamp ◽  
Maarten Limper ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcome ◽  
Antiphospholipid Syndrome ◽  
Meta Analysis ◽  
Outcome Predictors

scholarly journals Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Charalampos Siristatidis ◽  
Paraskevi Vogiatzi ◽  
George Salamalekis ◽  
Maria Creatsa ◽  
Nikos Vrachnis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Assisted Reproduction ◽  
Live Birth ◽  
Culture Media ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Assisted Reproduction Technologies ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine/growth factor produced by epithelial cells that exerts embryotrophic effects during the early stages of embryo development. We performed a systematic review, and six studies that were performed in humans undergoing assisted reproduction technologies (ART) were located. We wanted to evaluate if embryo culture media supplementation with GM-CSF could improve success rates. As the type of studies and the outcome parameters investigated were heterogeneous, we decided not to perform a meta-analysis. Most of them had a trend favoring the supplementation with GM-CSF, when outcomes were measured in terms of increased percentage of good-quality embryos reaching the blastocyst stage, improved hatching initiation and number of cells in the blastocyst, and reduction of cell death. However, no statistically significant differences were found in implantation and pregnancy rates in all apart from one large multicenter trial, which reported favorable outcomes, in terms of implantation and live birth rates. We propose properly conducted and adequately powered randomized controlled trials (RCTs) to further validate and extrapolate the current findings with the live birth rate to be the primary outcome measure.

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