Faculty Opinions recommendation of Meta-analysis of secure randomised controlled trials of β-blockade to prevent perioperative death in non-cardiac surgery.

2013 ◽  
Author(s):  
Paolo Severgnini
Keyword(s):  
Cardiac Surgery ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomised Controlled

scholarly journals Effectiveness of a gentamicin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials

2012 ◽  
Vol 94 (4) ◽  
pp. 227-231 ◽  
Author(s):  
S Creanor ◽  
A Barton ◽  
A Marchbank
Keyword(s):  
Cardiac Surgery ◽  
High Risk ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Current Evidence ◽  
Controlled Trials ◽  
Wound Infections ◽  
Insufficient Evidence ◽  
Sternal Wound Infections ◽  
Randomised Controlled

INTRODUCTION Gentamicin impregnated collagen sponges are licensed for use after cardiac surgery in over 50 countries but their effectiveness at preventing sternal wound infections (SWIs) remains uncertain. The aim of this meta-analysis was to assess the current evidence for effectiveness of such sponges at preventing SWIs in patients after cardiac surgery. METHODS A systematic search of the literature was undertaken and meta-analyses were performed on the results of the identified, eligible studies. Using random effects models, odds ratios (OR) and corresponding 95% confidence intervals (Cl) were calculated for all SWIs and deep SWIs for: a) all participants, and b) participants deemed as high risk. RESULTS Three unique randomised controlled trials (published between 2005 and 2010) involving 3,994 participants met the inclusion criteria. There was insufficient evidence of a significant difference between intervention and control groups for all SWIs (all participants: OR: 0.66, 95% Cl: 0.39–1.14; high risk participants: OR: 0.60, 95% Cl: 0.24–1.52). There was insufficient evidence of a significant benefit of the sponge in deep SWIs across all participants (OR: 0.72, 95% Cl: 0.47–1.10) but some evidence of benefit in terms of reducing the incidence of deep SWIs in high risk participants (OR: 0.62, 95% Cl: 0.39–0.98). CONCLUSIONS There is insufficient evidence of the effectiveness (or otherwise) of gentamicin impregnated sponges in preventing SWIs following cardiac surgery. However, some evidence does exist that such sponges can reduce the incidence of deep infections in high risk patients.

scholarly journals Meta-analysis of secure randomised controlled trials of β-blockade to prevent perioperative death in non-cardiac surgery

Heart ◽  
2013 ◽  
Vol 100 (6) ◽  
pp. 456-464 ◽  
Author(s):  
Sonia Bouri ◽  
Matthew James Shun-Shin ◽  
Graham D Cole ◽  
Jamil Mayet ◽  
Darrel P Francis
Keyword(s):  
Cardiac Surgery ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomised Controlled

scholarly journals How strong is the evidence for the use of perioperative β blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials

BMJ ◽  
2005 ◽  
Vol 331 (7512) ◽  
pp. 313-321 ◽  
Author(s):  
P J Devereaux ◽  
W Scott Beattie ◽  
Peter T-L Choi ◽  
Neal H Badner ◽  
Gordon H Guyatt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Surgery ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Β Blockers ◽  
Randomised Controlled

Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials

Heart ◽  
2011 ◽  
Vol 97 (20) ◽  
pp. 1636-1642 ◽  
Author(s):  
L. Harling ◽  
S. Rasoli ◽  
J. A. Vecht ◽  
H. Ashrafian ◽  
A. Kourliouros ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Antioxidant Vitamins ◽  
Controlled Trials ◽  
Randomised Controlled
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