Faculty Opinions recommendation of Twenty-four hour ocular perfusion pressure fluctuation and risk of normal-tension glaucoma progression.

Introduction and Aim: Glaucoma is a chronic optic neuropathy which is the leading cause of irreversible blindness across the globe. It is known that Intraocular pressure is responsible for these altered changes but recent experimental and clinical studies have reported that cerebrospinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD), may be an important cause of glaucomatous optic nerve damage, especially in subjects with normal-tension glaucoma. To assess the correlation between ocular perfusion pressure (OPP) and TLCPD in healthy young adults. Materials and Methods: One hundred healthy young adult volunteers comprising of 50 obese (25 males and 25 females) and 50 non-obese (25 males and 25 females) in the age group of 18-19 years among MBBS Phase I students of JSS Medical College, JSSU, Mysore were the subjects for the study. Blood Pressure and Intra Ocular Pressure were recorded. Mean arterial pressure (MAP), OPP, CSFPand TLCPD were calculated. Results: There exists a positive correlation (0.50) between OPP and TLCPD. There was a statistically significant difference in OPP, CSFP and TLCPD between obese and non-obese groups. Conclusion: The present study provides information on the relationship of TLCPD with CSFP and OPP that are higher in obese individuals.

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Effects of a dorzolamide/timolol fixed combination on diurnal intraocular pressure, heart rate, blood pressure, and ocular perfusion pressure in normal-tension glaucoma

Japanese Journal of Ophthalmology ◽

10.1007/s10384-016-0455-z ◽

2016 ◽

Vol 60 (5) ◽

pp. 377-382 ◽

Cited By ~ 1

Author(s):

Na Young Lee ◽

Hae-Young Lopilly Park ◽

Chan Kee Park

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Intraocular Pressure ◽

Perfusion Pressure ◽

Fixed Combination ◽

Normal Tension Glaucoma ◽

Ocular Perfusion Pressure ◽

Ocular Perfusion

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Reduced intraocular pressure and increased ocular perfusion pressure in normal tension glaucoma: A review of short-term studies with three dose regimens of latanoprost treatment

Survey of Ophthalmology ◽

10.1016/s0039-6257(97)80013-6 ◽

1997 ◽

Vol 41 ◽

pp. S89-S92 ◽

Cited By ~ 25

Author(s):

Erik L. Greve ◽

Alexander H. Rulo ◽

Stephen M. Drance ◽

Andrew C. Crichton ◽

Richard P. Mills ◽

...

Keyword(s):

Intraocular Pressure ◽

Perfusion Pressure ◽

Normal Tension Glaucoma ◽

Ocular Perfusion Pressure ◽

Short Term ◽

Ocular Perfusion

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Factors Related to a Right-Left Difference in Visual Field Defect in the Eyes with Untreated Normal Tension Glaucoma

Journal of Ophthalmology ◽

10.1155/2018/4595214 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Haruka Moroi ◽

Ayako Anraku ◽

Kyoko Ishida ◽

Goji Tomita

Keyword(s):

Visual Field ◽

Visual Field Defect ◽

Central Corneal Thickness ◽

Perfusion Pressure ◽

Corneal Thickness ◽

Normal Tension Glaucoma ◽

Spherical Equivalent ◽

Ocular Perfusion Pressure ◽

Ocular Perfusion ◽

Field Defect

Purpose. To investigate factors related to a right-left difference in visual field defect in untreated normal tension glaucoma (NTG). Methods. The medical records of 92 patients with untreated NTG were reviewed. Ocular blood flow was evaluated with laser speckle flowgraphy, and the mean blur rate (MBR) at the optic nerve head was analyzed. Relationships between right-left differences in mean deviation (MD), intraocular pressure, MBR, spherical equivalent, central corneal thickness, and mean ocular perfusion pressure were evaluated using Spearman’s rank correlation coefficient. Multiple regression analysis was used to detect factors contributing to a right-left difference in MD. Results. The right-left difference in MD was correlated with differences in intraocular pressure (r=−0.263, P=0.011), MBR (r=0.417, P<0.001), and spherical equivalent (r=0.213, P=0.042), but not with central corneal thickness or mean ocular perfusion pressure. Multiple regression analysis showed that a difference in MBR was the only significant contributor to a right-left difference in MD (slope 0.047, 95% confidence interval 0.025–0.069; P<0.001). Conclusion. In untreated NTG, a difference in blood flow at the optic nerve head was a significant contributor to a right-left difference in visual field defect.

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