Faculty Opinions recommendation of Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.

2015 ◽  
Author(s):  
Geneviève de Saint Basile
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Actin Network ◽  
Immune Synapse ◽  
Granule Secretion ◽  
Lytic Granule

scholarly journals Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

PLoS Biology ◽  
2011 ◽  
Vol 9 (9) ◽  
pp. e1001151 ◽  
Author(s):  
Gregory D. Rak ◽  
Emily M. Mace ◽  
Pinaki P. Banerjee ◽  
Tatyana Svitkina ◽  
Jordan S. Orange
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Actin Network ◽  
Immune Synapse ◽  
Granule Secretion ◽  
Lytic Granule

scholarly journals Natural killer cell granules converge to avoid collateral damage

2016 ◽  
Vol 215 (6) ◽  
pp. 765-767 ◽  
Author(s):  
Alex T. Ritter ◽  
Ira Mellman
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Killer Cell ◽  
Target Cells ◽  
Cytotoxic Lymphocytes ◽  
Collateral Damage ◽  
Polarized Secretion ◽  
Lytic Granule

To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward the intended target.

scholarly journals PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse

2018 ◽  
Vol 142 (4) ◽  
pp. 1311-1321.e8 ◽  
Author(s):  
Yu Huang ◽  
Zhiying Chen ◽  
Joon Hee Jang ◽  
Mirza S. Baig ◽  
Grant Bertolet ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Immunological Synapse ◽  
Killer Cell ◽  
Lytic Granule

scholarly journals The human natural killer cell immune synapse

1999 ◽  
Vol 96 (26) ◽  
pp. 15062-15067 ◽  
Author(s):  
D. M. Davis ◽  
I. Chiu ◽  
M. Fassett ◽  
G. B. Cohen ◽  
O. Mandelboim ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Human Natural Killer Cell ◽  
Immune Synapse

A STED-FLIM microscope applied to imaging the natural killer cell immune synapse

2011 ◽  
Author(s):  
M. O. Lenz ◽  
A. C. N. Brown ◽  
E. Auksorius ◽  
D. M. Davis ◽  
C. Dunsby ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Immune Synapse
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