scholarly journals Fas ligand and lytic granule differentially control cytotoxic dynamics of natural killer cell against cancer target

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 47163-47172 ◽  
Author(s):  
Yanting Zhu ◽  
Bo Huang ◽  
Jue Shi
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Killer Cell ◽  
Lytic Granule

scholarly journals Natural killer cell granules converge to avoid collateral damage

2016 ◽  
Vol 215 (6) ◽  
pp. 765-767 ◽  
Author(s):  
Alex T. Ritter ◽  
Ira Mellman
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Killer Cell ◽  
Target Cells ◽  
Cytotoxic Lymphocytes ◽  
Collateral Damage ◽  
Polarized Secretion ◽  
Lytic Granule

To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward the intended target.

scholarly journals PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse

2018 ◽  
Vol 142 (4) ◽  
pp. 1311-1321.e8 ◽  
Author(s):  
Yu Huang ◽  
Zhiying Chen ◽  
Joon Hee Jang ◽  
Mirza S. Baig ◽  
Grant Bertolet ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Immunological Synapse ◽  
Killer Cell ◽  
Lytic Granule

scholarly journals Soluble Fas ligand is associated with natural killer cell dynamics in coronary artery disease

2014 ◽  
Vol 233 (2) ◽  
pp. 616-622 ◽  
Author(s):  
Aleksander Szymanowski ◽  
Wei Li ◽  
Anna Lundberg ◽  
Chamilly Evaldsson ◽  
Lennart Nilsson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Killer Cell ◽  
Cell Dynamics ◽  
Soluble Fas ◽  
Soluble Fas Ligand ◽  
Artery Disease

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse

Hepatology ◽  
2012 ◽  
Vol 56 (2) ◽  
pp. 555-566 ◽  
Author(s):  
Akihito Okazaki ◽  
Nobuhiko Hiraga ◽  
Michio Imamura ◽  
C. Nelson Hayes ◽  
Masataka Tsuge ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Killer Cell ◽  
Human Hepatocyte ◽  
Chimeric Mouse ◽  
Ligand Interaction

scholarly journals Rat Spleen Dendritic Cells Express Natural Killer Cell Receptor Protein 1 (NKR-P1) and Have Cytotoxic Activity to Select Targets via a Ca2+-dependent Mechanism

1997 ◽  
Vol 186 (3) ◽  
pp. 467-472 ◽  
Author(s):  
Régis Josien ◽  
Michèle Heslan ◽  
Jean-Paul Soulillou ◽  
Maria-Cristina Cuturi
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Killer Cell ◽  
Cell Receptor ◽  
Receptor Protein ◽  
Natural Killer Cell Receptor ◽  
Major Function

Dendritic cells (DC) are a subset of leukocytes whose major function is antigen presentation. We investigated the phenotype and function of enriched (95–98.5%) rat DC. We show that both spleen and thymus DC express the natural killer cell receptor protein 1 (NKR-P1) as a disulfide linked homodimer of 60 kD. Freshly isolated DC express a low level of NKR-P1, which is strongly upregulated after overnight culture. Spleen, but not thymus DC, were able to kill the NK-sensitive YAC-1 cell line in vitro, and since this killing was Ca2+ dependent, a Fas ligand–Fas interaction was probably not involved. Besides their potent antigen-presenting function, DC can thus be cytotoxic for some tumor targets.

Fas Ligand–Mediated Lethal Hepatitis After Rapid Lysis of a Localized Natural Killer Cell Lymphoma

2006 ◽  
Vol 6 (5) ◽  
pp. 417-419 ◽  
Author(s):  
David Ghez ◽  
Diane Damotte ◽  
Susan P. Perrine ◽  
Douglas V. Faller ◽  
Daniéle Canioni ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Natural Killer Cell Lymphoma
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