scholarly journals PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse

2018 ◽  
Vol 142 (4) ◽  
pp. 1311-1321.e8 ◽  
Author(s):  
Yu Huang ◽  
Zhiying Chen ◽  
Joon Hee Jang ◽  
Mirza S. Baig ◽  
Grant Bertolet ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Immunological Synapse ◽  
Killer Cell ◽  
Lytic Granule

scholarly journals Natural killer cell granules converge to avoid collateral damage

2016 ◽  
Vol 215 (6) ◽  
pp. 765-767 ◽  
Author(s):  
Alex T. Ritter ◽  
Ira Mellman
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Killer Cell ◽  
Target Cells ◽  
Cytotoxic Lymphocytes ◽  
Collateral Damage ◽  
Polarized Secretion ◽  
Lytic Granule

To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward the intended target.

scholarly journals A Targeted siRNA Screen Identifies Regulators of Cdc42 Activity at the Natural Killer Cell Immunological Synapse

2011 ◽  
Vol 4 (201) ◽  
pp. ra81-ra81 ◽  
Author(s):  
L. M. Carlin ◽  
R. Evans ◽  
H. Milewicz ◽  
L. Fernandes ◽  
D. R. Matthews ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Immunological Synapse ◽  
Killer Cell ◽  
Sirna Screen

scholarly journals Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

2017 ◽  
Vol 8 (12) ◽  
pp. 861-877 ◽  
Author(s):  
Dongfang Liu ◽  
Shuo Tian ◽  
Kai Zhang ◽  
Wei Xiong ◽  
Ndongala Michel Lubaki ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Chimeric Antigen Receptor ◽  
Synapse Formation ◽  
Immunological Synapse ◽  
Killer Cell ◽  
Antigen Receptor
Sign in / Sign up

Export Citation Format

Share Document