Faculty Opinions recommendation of Valganciclovir for symptomatic congenital cytomegalovirus disease.

2017 ◽  
Author(s):  
Vincent Emery
Keyword(s):  
Cytomegalovirus Disease ◽  
Congenital Cytomegalovirus

scholarly journals A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?

2020 ◽  
Vol 22 (1) ◽  
pp. 214
Author(s):  
Michelle A. Fisher ◽  
Megan L. Lloyd
Keyword(s):  
Human Cytomegalovirus ◽  
Murine Cytomegalovirus ◽  
Clinical Samples ◽  
Mouse Strains ◽  
Cytomegalovirus Disease ◽  
Wild Mice ◽  
Congenital Cytomegalovirus ◽  
Non Invasive ◽  
Species Specific ◽  
Disseminated Disease

Since murine cytomegalovirus (MCMV) was first described in 1954, it has been used to model human cytomegalovirus (HCMV) diseases. MCMV is a natural pathogen of mice that is present in wild mice populations and has been associated with diseases such as myocarditis. The species-specific nature of HCMV restricts most research to cell culture-based studies or to the investigation of non-invasive clinical samples, which may not be ideal for the study of disseminated disease. Initial MCMV research used a salivary gland-propagated virus administered via different routes of inoculation into a variety of mouse strains. This revealed that the genetic background of the laboratory mice affected the severity of disease and altered the extent of subsequent pathology. The advent of genetically modified mice and viruses has allowed new aspects of disease to be modeled and the opportunistic nature of HCMV infection to be confirmed. This review describes the different ways that MCMV has been used to model HCMV diseases and explores the continuing difficulty faced by researchers attempting to model HCMV congenital cytomegalovirus disease using the mouse model.

Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis

2012 ◽  
Vol 40 (4) ◽  
Author(s):  
Horst Buxmann ◽  
Otto M.v. Stackelberg ◽  
Rolf L. Schlößer ◽  
Gisela Enders ◽  
Markus Gonser ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Cytomegalovirus Disease ◽  
Congenital Cytomegalovirus

scholarly journals Pharmacokinetic and Pharmacodynamic Assessment of Oral Valganciclovir in the Treatment of Symptomatic Congenital Cytomegalovirus Disease

2008 ◽  
Vol 197 (6) ◽  
pp. 836-845 ◽  
Author(s):  
David W. Kimberlin ◽  
Edward P. Acosta ◽  
Pablo J. Sánchez ◽  
Sunil Sood ◽  
Vish Agrawal ◽  
...  
Keyword(s):  
Cytomegalovirus Disease ◽  
Congenital Cytomegalovirus ◽  
Oral Valganciclovir

Circulating Interferon in Cytomegalovirus Infected Bone-Marrow-Transplant Recipients and in Infants with Congenital Cytomegalovirus Disease

1992 ◽  
Vol 1992 (special_issue) ◽  
pp. 91-98 ◽  
Author(s):  
A. RHODES-FEUILLETTE ◽  
M. CANIVET ◽  
H. CHAMPSAUR ◽  
E. GLUCKMAN ◽  
M.C. MAZERON ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Transplant Recipients ◽  
Cytomegalovirus Disease ◽  
Congenital Cytomegalovirus

Symptomatic infant characteristics of congenital cytomegalovirus disease in Australia

2005 ◽  
Vol 41 (8) ◽  
pp. 449-452 ◽  
Author(s):  
Sian C Munro ◽  
Daniel Trincado ◽  
Beverley Hall ◽  
William D Rawlinson
Keyword(s):  
Cytomegalovirus Disease ◽  
Congenital Cytomegalovirus
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