Faculty Opinions recommendation of Analgesic effect of perioperative escitalopram in high pain catastrophizing patients after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial.

2015 ◽  
Author(s):  
Darin Correll
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Analgesic Effect ◽  
Pain Catastrophizing ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Knee

Response to Letter to the Editor on “A Prospective Double-Blind Placebo Controlled Trial of Topical Tranexamic Acid in Total Knee Arthroplasty”

2020 ◽  
Vol 35 (4) ◽  
pp. 1161-1162
Author(s):  
Andrew G. Georgiadis ◽  
Stephanie J. Muh ◽  
Craig D. Silverton ◽  
Robb M. Weir ◽  
Michael W. Laker
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Letter To The Editor ◽  
Total Knee ◽  
Topical Tranexamic Acid

High-volume infiltration analgesia in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial

2008 ◽  
Vol 52 (10) ◽  
pp. 1331-1335 ◽  
Author(s):  
L. Ø. ANDERSEN ◽  
H. HUSTED ◽  
K. S. OTTE ◽  
B. B. KRISTENSEN ◽  
H. KEHLET
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
High Volume ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Knee ◽  
Infiltration Analgesia

scholarly journals Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial

2017 ◽  
Vol 191 (3) ◽  
pp. 356-362 ◽  
Author(s):  
V. Lindberg-Larsen ◽  
H. Kehlet ◽  
K. Pilely ◽  
J. Bagger ◽  
M. L. Rovsing ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Pentraxin 3 ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Knee

A Prospective Double-Blind Placebo Controlled Trial of Topical Tranexamic Acid in Total Knee Arthroplasty

2013 ◽  
Vol 28 (8) ◽  
pp. 78-82 ◽  
Author(s):  
Andrew G. Georgiadis ◽  
Stephanie J. Muh ◽  
Craig D. Silverton ◽  
Robb M. Weir ◽  
Michael W. Laker
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Knee ◽  
Topical Tranexamic Acid

scholarly journals Analgesic Effect of Perioperative Duloxetine in Patients After Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

2021 ◽  
Author(s):  
Mingcheng Yuan ◽  
Tingting Tang ◽  
Zichuan Ding ◽  
Hao Li ◽  
Zongke Zhou
Keyword(s):  
Total Knee Arthroplasty ◽  
Placebo Group ◽  
Knee Arthroplasty ◽  
Postoperative Period ◽  
Analgesic Effect ◽  
Controlled Trial ◽  
Double Blind ◽  
Management Protocol ◽  
Significant Difference ◽  
Total Knee

Abstract Background: To investigate the analgesic effect of perioperative use of duloxetine in patients received total knee arthroplasty (TKA). Method: The hospital pharmacy prepared small capsules containing either duloxetine or starch (placebo) which were all identical in appearance and weight (1:1). Enrolled patients were given a capsule (containing either 60 mg duloxetine or 60 mg placebo) every night before sleep since preoperative day 2 till postoperative day 14 (17 days in all) by a nurse who were not involved in this trial. Other perioperative managements were the same in the two groups. The primary outcome was the VAS score (both rVAS and aVAS) throughout the perioperative period. The secondary outcomes included opioid consumption, range of motion, including both active ROM (aROM) and passive ROM (pROM) and adverse events. Result: rVAS in duloxetine group were significantly less than placebo group throughout the postoperative period (From postoperative 2 hours to postoperative 3 months) (P<0.05). In terms of aVAS, similarly, duloxetine group had less aVAS than placebo group throughout the postoperative period (From postoperative 6 hours to postoperative 3 months) (P<0.05). During the postoperative period (From postoperative day 1 to 7), patients in duloxetine group consumed significantly less opioids per day than the placebo group (P<0.05). aROM in duloxetine group were significantly better than placebo group from postoperative 6 hours to postoperative day 5 (P<0.05), since postoperative day 6, the aROM became comparable between the two groups (P>0.05). In terms of pROM, duloxetine group had significantly better pROM from postoperative 6 hours to postoperative day 4 (P<0.05), thereafter, the pROM between the two groups became comparable (P>0.05). No significant difference was found between the two groups in the rates of dizziness, bleeding, sweating, fatigue and dryness of mouth. In the placebo group, more patients got nausea/vomiting and constipation (P<0.05). However, in terms of drowsiness, duloxetine group was reported higher rate (P<0.05). Conclusion: Duloxetine could reduce acute postoperative pain and decrease the opioids consumption as well as accelerating postoperative recovery, without increasing the risk of adverse medication effects in patients undergoing TKA. Duloxetine could act as a good supplement in multimodal pain management protocol for patients undergoing TKA. Trial registration statement: This study was registered in the Chinese Clinical Trial Registry (ChiCTR2000033910). The date of registration was 06/16/2020.

scholarly journals The effect of pre-operative methylprednisolone on early endothelial damage after total knee arthroplasty: a randomised, double-blind, placebo-controlled trial

Anaesthesia ◽  
2017 ◽  
Vol 72 (10) ◽  
pp. 1217-1224 ◽  
Author(s):  
V. Lindberg-Larsen ◽  
S. R. Ostrowski ◽  
M. Lindberg-Larsen ◽  
M. L. Rovsing ◽  
P. I. Johansson ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Endothelial Damage ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Knee
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