Faculty Opinions recommendation of Bone marrow lesions in hip osteoarthritis are characterized by increased bone turnover and enhanced angiogenesis.

2016 ◽  
Author(s):  
Eleftherios Paschalis
Keyword(s):  
Bone Marrow ◽  
Bone Turnover ◽  
Hip Osteoarthritis ◽  
Bone Marrow Lesions

scholarly journals Bone marrow lesions in hip osteoarthritis are characterized by increased bone turnover and enhanced angiogenesis

2016 ◽  
Vol 24 (10) ◽  
pp. 1745-1752 ◽  
Author(s):  
M. Shabestari ◽  
J. Vik ◽  
J.E. Reseland ◽  
E.F. Eriksen
Keyword(s):  
Bone Marrow ◽  
Bone Turnover ◽  
Hip Osteoarthritis ◽  
Bone Marrow Lesions

scholarly journals Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays

2020 ◽  
Vol 23 (6) ◽  
pp. 788-799
Author(s):  
Maziar Shabestari ◽  
Yashar R. Shabestari ◽  
Maria A. Landin ◽  
Milaim Pepaj ◽  
Timothy P. Cleland ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hip Osteoarthritis ◽  
Bone Marrow Lesions ◽  
Protein Levels ◽  
Altered Protein

Bone marrow lesions are characterized by increased bone turnover and increased vascularity

2014 ◽  
Author(s):  
Maziar Shabestari ◽  
Jarle Vik ◽  
Janne Reseland ◽  
Erik Fink Eriksen
Keyword(s):  
Bone Marrow ◽  
Bone Turnover ◽  
Bone Marrow Lesions

scholarly journals Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

2016 ◽  
Vol 68 (7) ◽  
pp. 1648-1659 ◽  
Author(s):  
T. Mark Campbell ◽  
Sarah M. Churchman ◽  
Alejandro Gomez ◽  
Dennis McGonagle ◽  
Philip G. Conaghan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Hip Osteoarthritis ◽  
Bone Marrow Lesions ◽  
Cell Alterations

scholarly journals Bone marrow lesions: etiology and pathogenesis at the hip

2020 ◽  
Author(s):  
Maria A Munsch ◽  
Marc R Safran ◽  
Matthew C Mai ◽  
W Kelton Vasileff
Keyword(s):  
Bone Marrow ◽  
Subchondral Bone ◽  
Articular Surface ◽  
Hip Osteoarthritis ◽  
The Body ◽  
Bone Marrow Lesions ◽  
Neoplastic Processes ◽  
Treatment And Prevention ◽  
Subchondral Bone Cysts ◽  
Independent Risk Factors

Abstract Bone marrow lesions (BML) are painful changes in subchondral bone which can be reliably identified on magnetic resonance imaging and have been identified in patients suffering from hip osteoarthritis (OA) and related conditions. Created via repetitive microdamage at the articular surface and dysregulated subchondral healing, BML have been linked to traumatic, inflammatory, degenerative, metabolic and neoplastic processes. While BML are known to be a common pathology throughout the body, BML at the hip have not been extensively studied in comparison to those at the knee. Due to the hip’s unique biomechanical architecture, function and loading, and independent risk factors leading to hip OA, hip BMLs must be independently understood. The identification of BML in the setting of a pre-osteoarthritic condition may provide a target for treatment and prevention of joint degeneration. By continuing to define and refine the relationships between BML, subchondral bone cysts and OA, prevention, diagnosis and treatment of OA could shift, leading to an improved quality of life and increased longevity of individuals’ native hips.

scholarly journals Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb

2018 ◽  
Vol 7 (6) ◽  
pp. 406-413 ◽  
Author(s):  
M. Shabestari ◽  
N. J. Kise ◽  
M. A. Landin ◽  
S. Sesseng ◽  
J. C. Hellund ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Turnover ◽  
Weight Bearing ◽  
Histological Changes ◽  
Trabecular Thickness ◽  
Bone Marrow Lesions ◽  
Dynamic Histomorphometry ◽  
Water Signal ◽  
Femoral Heads ◽  
Tissue Changes

ObjectivesLittle is known about tissue changes underlying bone marrow lesions (BMLs) in non-weight-bearing joints with osteoarthritis (OA). Our aim was to characterize BMLs in OA of the hand using dynamic histomorphometry. We therefore quantified bone turnover and angiogenesis in subchondral bone at the base of the thumb, and compared the findings with control bone from hip OA.MethodsPatients with OA at the base of the thumb, or the hip, underwent preoperative MRI to assess BMLs, and tetracycline labelling to determine bone turnover. Three groups were compared: trapezium bones removed by trapeziectomy from patients with thumb base OA (n = 20); femoral heads with (n = 24); and those without (n = 9) BMLs obtained from patients with hip OA who underwent total hip arthroplasty.ResultsAll trapezium bones demonstrated MRI-defined BMLs. Compared with femoral heads without BMLs, the trapezia demonstrated significantly higher bone turnover (mean sd 0.2 (0.1) versus 0.01 (0.01) µm3/µm2/day), mineralizing surface (18.5% (13.1) versus 1.4% (1.3)) and vascularity (5.2% (1.1) versus 1.2% (0.6)). Femoral heads with BMLs exhibited higher bone turnover (0.3 (0.2) versus 0.2 (0.1) µm3/µm2/day), a higher mineralization rate (26.6% (10.6) versus 18.6% (11.9)) and greater trabecular thickness (301.3 µm (108) versus 163.6 µm (24.8)) than the trapezia.ConclusionBone turnover and angiogenesis were enhanced in BMLs of both the thumb base and hip OA, of which the latter exhibited the highest bone turnover. Thus, the increase in bone turnover in weight-bearing joints like the hip may be more pronounced than less mechanically loaded osteoarthritic joints demonstrating BMLs. The histological changes observed may explain the water signal from BMLs on MRI. Cite this article: M. Shabestari, N. J. Kise, M. A. Landin, S. Sesseng, J. C. Hellund, J. E. Reseland, E. F. Eriksen, I. K. Haugen. Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb. Bone Joint Res 2018;7:406–413. DOI: 10.1302/2046-3758.76.BJR-2017-0083.R3.

scholarly journals Biochemical markers of bone turnover and their association with bone marrow lesions

2008 ◽  
Vol 10 (4) ◽  
pp. R102 ◽  
Author(s):  
David J Hunter ◽  
Michael LaValley ◽  
Jiang Li ◽  
Doug C Bauer ◽  
Michael Nevitt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Bone Marrow Lesions ◽  
Markers Of Bone Turnover

Validation of a Knowledge Transfer Tool According to the OMERACT Filter: Does Web-based Real-time Iterative Calibration Enhance the Evaluation of Bone Marrow Lesions in Hip Osteoarthritis?

2017 ◽  
Vol 44 (11) ◽  
pp. 1713-1717 ◽  
Author(s):  
Jacob L. Jaremko ◽  
Omar Azmat ◽  
Robert G.W. Lambert ◽  
Paul Bird ◽  
Ida K. Haugen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Real Time ◽  
Interobserver Reliability ◽  
Hip Osteoarthritis ◽  
New Method ◽  
Training Environment ◽  
Web Based ◽  
Bone Marrow Lesions ◽  
Group B ◽  
The Web

Objective.To assess reliability and feasibility of using a Web-based interface and interactive online calibration tool for magnetic resonance imaging (MRI) scoring of bone marrow lesions (BML) in osteoarthritis (OA), applied to the Hip MR Inflammation Scoring System (HIMRISS).Methods.Seven readers new to HIMRISS (3 radiologists, 4 rheumatologists) scored coronal short-tau inversion recovery MRI from a hip OA observational study obtained pre- and 8-week poststeroid injection (n = 40 × 2 scans × 2 hips = 160 hips). By crossover design, Group B (4 readers) scored 20 patients (40 hips) using conventional spreadsheet-based methods and then another 20 using a Web-based interface and an online real-time iterative calibration (RETIC) training module. Group A (3 readers) reversed the order, scoring the first 20 subjects by the new method and the final 20 conventionally. Outcomes included ICC and reader survey.Results.Interobserver reliability for BML status was high by both spreadsheet and Web-based methods (0.84–0.90), regardless of the order in which scoring was performed. Reliability of change scores was moderate and improved with training. Improvement was greater in readers who began with the spreadsheet method and then used the Web-based method than in those who began with the Web-based method, especially at the acetabulum. Readers found Web-based/RETIC scoring more user-friendly and nearly 50% faster than traditional spreadsheet methods.Conclusion.HIMRISS offers reliable BML scoring in OA, whether by conventional spreadsheet-based scoring or by a Web-based interface with interactive feedback. The new method allowed faster readings, provided a consistent training environment that helped inexperienced readers achieve reliability equivalent to that of conventional methods, and was preferred by the readers.

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