Bone Marrow Lesions Associated With Cartilage Damage at Follow-Up

2008 ◽  
Vol 7 (2) ◽  
pp. 7
Keyword(s):  
Bone Marrow ◽  
Cartilage Damage ◽  
Bone Marrow Lesions

The Fate of Bone Marrow Lesions After Open Wedge High Tibial Osteotomy: A Comparison Between Knees With Primary Osteoarthritis and Subchondral Insufficiency Fractures

2021 ◽  
pp. 036354652110021
Author(s):  
Han Gyeol Choi ◽  
Joo Sung Kim ◽  
Hyun Jin Yoo ◽  
You Sun Jung ◽  
Yong Seuk Lee
Keyword(s):  
Bone Marrow ◽  
High Tibial Osteotomy ◽  
Insufficiency Fracture ◽  
Tibial Osteotomy ◽  
Pathological Feature ◽  
Open Wedge ◽  
Varus Malalignment ◽  
Bone Marrow Lesions ◽  
Wedge High Tibial Osteotomy

Background: Subchondral insufficiency fracture of the knee (SIFK) is characterized by a subchondral lesion that may lead to end-stage osteoarthritis (OA). In patients who have SIFK in a precollapse state with varus malalignment, a joint-preserving technique such as open wedge high tibial osteotomy (OWHTO) should be considered. Purpose: To evaluate the efficacy of OWHTO in primary OA and SIFK-dominant OA by clinical and radiological evaluations including magnetic resonance imaging (MRI). Study Design: Cohort study; Level of evidence 3. Methods: A total of 33 SIFK-dominant OA knees and 66 with primary OA that underwent biplanar OWHTO between March 2014 and February 2016 were included after 1:2 propensity score matching. The MRI Osteoarthritis Knee Score was used to assess bone marrow lesions (BMLs) preoperatively and at follow-up. The weightbearing line ratio, the hip-knee-ankle angle, and the joint line convergence angle were measured. The clinical outcomes assessed were range of motion, the American Knee Society Score, and the Western Ontario and McMaster University (WOMAC) score. Results: The mean follow-up period was 41.2 ± 12.6 months. The distribution of preoperative BML grade in the SIFK-dominant OA group was significantly higher in both the femur and tibia ( P < .001 and <.001, respectively) than that in the primary OA group. However, the difference was not significant postoperatively (femur, P = .425; tibia, P = .462). In both groups, postoperative BMLs showed significant improvement compared with preoperative BMLs (primary OA [femur, P < .001; tibia, P = .001] and SIFK-dominant OA [femur, P < .001; tibia, P < .001]). The WOMAC pain score was higher in the SIFK-dominant OA group preoperatively (primary OA, 7.0 ± 3.73; SIFK-dominant OA, 9.17 ± 2.6; P = .032) even though it was not different at the final follow-up (primary OA, 2.11 ± 1.7; SIFK-dominant OA, 1.79 ± 1.32; P = .179). Conclusion: OWHTO is an effective procedure not only for primary OA but also for SIFK-dominant OA. OWHTO can improve BMLs, which represent the main pathological feature of SIFK. Therefore, in patients who have SIFK with varus malalignment, OWHTO can be an attractive treatment option for preserving the joint and enhancing subchondral bone healing.

scholarly journals Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST study

2013 ◽  
Vol 21 (2) ◽  
pp. 306-313 ◽  
Author(s):  
M.D. Crema ◽  
D.T. Felson ◽  
F.W. Roemer ◽  
K. Wang ◽  
M.D. Marra ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Damage ◽  
Cartilage Loss ◽  
Bone Marrow Lesions ◽  
And Cartilage ◽  
Over Time

scholarly journals Novel biomarkers for osteoarthritis are linked to pain sensitization, bone marrow lesions and cartilage damage

2018 ◽  
Vol 26 ◽  
pp. S190-S191
Author(s):  
L. Assi ◽  
G. Whitley ◽  
F. Howe ◽  
N. Sofat
Keyword(s):  
Bone Marrow ◽  
Cartilage Damage ◽  
Bone Marrow Lesions ◽  
Pain Sensitization ◽  
Novel Biomarkers ◽  
And Cartilage

Increasing synovitis and bone marrow lesions are associated with incident joint tenderness in hand osteoarthritis

2015 ◽  
Vol 75 (4) ◽  
pp. 702-708 ◽  
Author(s):  
Ida K Haugen ◽  
Barbara Slatkowsky Christensen ◽  
Pernille Bøyesen ◽  
Sølve Sesseng ◽  
Désirée van der Heijde ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Bone Marrow ◽  
Longitudinal Study ◽  
Hand Osteoarthritis ◽  
Bone Marrow Lesions ◽  
Contrast Enhanced ◽  
Joint Tenderness ◽  
Structural Progression ◽  
Generalised Estimating Equations

ObjectivesTo explore whether changes of MRI-defined synovitis and bone marrow lesions (BMLs) are related to changes in joint tenderness in a 5-year longitudinal study of the Oslo hand osteoarthritis (OA) cohort.MethodsWe included 70 patients (63 women, mean (SD) age 67.9 (5.5) years). BMLs and contrast-enhanced synovitis in the distal and proximal interphalangeal joints were evaluated on 0–3 scales in n=69 and n=48 patients, respectively. Among joints without tenderness at baseline, we explored whether increasing/incident synovitis and BMLs were associated with incident joint tenderness using generalised estimating equations. Among joints with tenderness at baseline, we explored whether decreasing or resolution of synovitis and BMLs were associated with loss of joint tenderness. We adjusted for age, sex, body mass index, follow-up time and changes in radiographic OA.ResultsAmong joints without tenderness at baseline, increasing/incident synovitis and BMLs were seen in 45 of 220 (20.5%) and 47 of 312 (15.1%) joints, respectively. Statistically significant associations to incident joint tenderness were found for increasing/incident synovitis (OR=2.66, 95% CI 1.38 to 5.11) and BMLs (OR=2.85, 95% CI 1.23 to 6.58) independent of structural progression. We found a trend that resolution of synovitis (OR=1.72, 95% CI 0.80 to 3.68) and moderate/large decreases of BMLs (OR=1.90, 95% CI 0.57 to 6.33) were associated with loss of joint tenderness, but these associations were non-significant.ConclusionsThe Oslo hand OA cohort is the first study with longitudinal hand MRIs. Increasing synovitis and BMLs were significantly associated with incident joint tenderness, whereas no significant associations were found for decreasing or loss of synovitis and BMLs.

scholarly journals Prevalence of mediopatellar plica in subjects with knee pain and the association with patellofemoral cartilage damage and bone marrow lesions: the jog study

2012 ◽  
Vol 20 ◽  
pp. S13-S14
Author(s):  
L. XU ◽  
D. Hayashi ◽  
A. Guermazi ◽  
C. Kwoh ◽  
M.J. Hannon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Knee Pain ◽  
Cartilage Damage ◽  
Bone Marrow Lesions

SAT0323 Marked bilateral symmetricity of cartilage damage, bone marrow lesions and meniscal damage in subjects with knee pain and with or without radiographic osteoarthritis: The jog study

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 581.2-581
Author(s):  
F.W. Roemer ◽  
C.K. Kwoh ◽  
M.J. Hannon ◽  
R.M. Boudreau ◽  
S.M. Green ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Knee Pain ◽  
Cartilage Damage ◽  
Bone Marrow Lesions ◽  
Radiographic Osteoarthritis ◽  
Meniscal Damage

scholarly journals Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months

2012 ◽  
Vol 20 (10) ◽  
pp. 1120-1126 ◽  
Author(s):  
N.A. Segal ◽  
A.M. Kern ◽  
D.D. Anderson ◽  
J. Niu ◽  
J. Lynch ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Contact Stress ◽  
Cartilage Damage ◽  
Bone Marrow Lesions ◽  
And Cartilage

scholarly journals Subchondroplasty in the Treatment of Bone Marrow Lesions of the Knee: Preliminary Experience on First 15 Patients

Joints ◽  
2021 ◽  
Author(s):  
Stefano Pasqualotto ◽  
Andrea Vincenzo Sgroi ◽  
Araldo Causero ◽  
Paolo Di Benedetto ◽  
Claudio Zorzi
Keyword(s):  
Bone Marrow ◽  
Pain Relief ◽  
Knee Injury ◽  
Case Series ◽  
Functional Improvement ◽  
Level Of Evidence ◽  
Bone Marrow Lesions ◽  
Pain Scores ◽  
Outcome Scores

Abstract Purpose The aim of this prospective study was to assess the effectiveness in terms of pain relief and functional improvement of the Subchondroplasty procedure in the treatment of osteoarthritis-related bone marrow lesions (BMLs) of the knee. Methods The study included first 15 consecutive patients undergone to Subchondroplasty procedure for the treatment of chronic degenerative BMLs in which previous conservative treatment have failed. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, Knee Injury and Osteoarthritis Outcome Scores (KOOS), and visual analog scale (VAS) pain scores were obtained preoperatively and at 1, 6, and 12 months of follow-up. Results WOMAC scores significantly improved from 39.7 ± 20.2 before surgery to 26.8 ± 16.1 at the 1-month follow-up (p = 0.045). A further significant improvement to 15.5 ± 12.7 (p = 0.02) and to 8.6 ± 3.1 (p < 0.01) was obtained both at 6-month and at 1-year follow-up. KOOS scores improved significantly from 47.5 ± 16.6 before surgery to 65.4 ± 14.9 at 1 month (p = 0.013) and to 80.4 ± 15.1 at 6-month follow-up (p = 0.01). A further improvement to 85.6 ± 15.1 was recorded 1 year postoperatively, although nonsignificant. VAS score showed a significant improvement from 55.8 ± 20.5 preoperatively to 36.2 ± 16.9 at 1 month (p = 0.008) and to 18.2 ± 17.3 at 6-month follow-up (p = 0.005). This further improved to 12.8 ± 17.9 at 1-year follow-up, although not significantly. Conclusion Subchondroplasty procedure represents a safe and valid surgical option in the treatment of osteoarthritis-related BMLs of the knee, providing an improvement in terms of pain relief and functional recovery. Longer studies are required to evaluate how long these improvements may last. Level of Evidence Therapeutic case-series, Level IV study.

scholarly journals Cartilage damage, bone marrow lesions and meniscal lesions predict quantitatively measured loss of cartilage over 30-months: the most study

2014 ◽  
Vol 22 ◽  
pp. S356 ◽  
Author(s):  
A. Guermazi ◽  
F. Eckstein ◽  
D. Hayashi ◽  
F.W. Roemer ◽  
W. Wirth ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cartilage Damage ◽  
Bone Marrow Lesions ◽  
Meniscal Lesions
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