Faculty Opinions recommendation of Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.

2017 ◽  
Author(s):  
Nicola Heller
Keyword(s):  
Interleukin 33 ◽  
Type 2 Immunity

scholarly journals Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

2012 ◽  
Vol 209 (3) ◽  
pp. 607-622 ◽  
Author(s):  
Marsha Wills-Karp ◽  
Reena Rani ◽  
Krista Dienger ◽  
Ian Lewkowich ◽  
James G. Fox ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Molecular Mechanisms ◽  
Nippostrongylus Brasiliensis ◽  
Trefoil Factor ◽  
Interleukin 33 ◽  
Parasitic Helminths ◽  
Type 2 Immunity ◽  
Th2 Responses ◽  
Trefoil Factor 2

The molecular mechanisms that drive mucosal T helper type 2 (TH2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell–derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a TH2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal TH2 responses.

scholarly journals Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung

Immunity ◽  
2016 ◽  
Vol 45 (6) ◽  
pp. 1285-1298 ◽  
Author(s):  
Ismé M. de Kleer ◽  
Mirjam Kool ◽  
Marjolein J.W. de Bruijn ◽  
Monique Willart ◽  
Justine van Moorleghem ◽  
...  
Keyword(s):  
Interleukin 33 ◽  
Type 2 Immunity
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