Faculty Opinions recommendation of A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone.

2017 ◽  
Author(s):  
Jens Rettig ◽  
David Stevens
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
Vesicle Fusion ◽  
Subunit C ◽  
Vesicle Docking ◽  
C Terminus ◽  
Presynaptic Active Zone ◽  
Synaptic Vesicle Fusion ◽  
Α1 Subunit

scholarly journals A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Matthias Lübbert ◽  
R Oliver Goral ◽  
Rachel Satterfield ◽  
Travis Putzke ◽  
Arn MJM van den Maagdenberg ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
Neurotransmitter Release ◽  
Physical Distance ◽  
Subunit C ◽  
Vesicle Docking ◽  
C Terminus ◽  
Synaptic Vesicle Release ◽  
Synaptic Vesicle Fusion ◽  
Α1 Subunit

In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is principally mediated by CaV2.1 calcium channels (CaV2.1) and is highly dependent on the physical distance between CaV2.1 and synaptic vesicles (coupling). Although various active zone proteins are proposed to control coupling and abundance of CaV2.1 through direct interactions with the CaV2.1 α1 subunit C-terminus at the active zone, the role of these interaction partners is controversial. To define the intrinsic motifs that regulate coupling, we expressed mutant CaV2.1 α1 subunits on a CaV2.1 null background at the calyx of Held presynaptic terminal. Our results identified a region that directly controlled fast synaptic vesicle release and vesicle docking at the active zone independent of CaV2.1 abundance. In addition, proposed individual direct interactions with active zone proteins are insufficient for CaV2.1 abundance and coupling. Therefore, our work advances our molecular understanding of CaV2.1 regulation of neurotransmitter release in mammalian CNS synapses.

Amyloid Precursor Protein Knockout Diminishes Synaptic Vesicle Proteins at the Presynaptic Active Zone in Mouse Brain

2014 ◽  
Vol 11 (10) ◽  
pp. 971-980 ◽  
Author(s):  
Melanie Laßek ◽  
Jens Weingarten ◽  
Amparo Acker-Palmer ◽  
Sandra Bajjalieh ◽  
Ulrike Muller ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Synaptic Vesicle ◽  
Mouse Brain ◽  
Active Zone ◽  
Precursor Protein ◽  
Presynaptic Active Zone ◽  
Vesicle Proteins

scholarly journals Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation

Neuron ◽  
1995 ◽  
Vol 14 (5) ◽  
pp. 991-998 ◽  
Author(s):  
Yun Kee ◽  
Richard C Lin ◽  
Shu-Chan Hsu ◽  
Richard H Scheller
Keyword(s):  
Complex Formation ◽  
Synaptic Vesicle ◽  
Vesicle Fusion ◽  
Synaptic Vesicle Fusion
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