scholarly journals Faculty Opinions recommendation of A VLP-based vaccine provides complete protection against Nipah virus challenge following multiple-dose or single-dose vaccination schedules in a hamster model.

2019 ◽  
Author(s):  
Branka Horvat
Keyword(s):  
Single Dose ◽  
Multiple Dose ◽  
Nipah Virus ◽  
Complete Protection ◽  
Hamster Model ◽  
Virus Challenge

scholarly journals Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters

2019 ◽  
Vol 221 (Supplement_4) ◽  
pp. S493-S498 ◽  
Author(s):  
Michael K Lo ◽  
Jessica R Spengler ◽  
Stephen R Welch ◽  
Jessica R Harmon ◽  
JoAnn D Coleman-McCray ◽  
...  
Keyword(s):  
Single Dose ◽  
Immune Responses ◽  
Messenger Rna ◽  
Nipah Virus ◽  
Hendra Virus ◽  
Highly Pathogenic ◽  
Syrian Hamsters ◽  
Virus Challenge ◽  
Pathogenic Viruses ◽  
Rna Vaccine

Abstract In the absence of approved vaccines and therapeutics for use in humans, Nipah virus (NiV) continues to cause fatal outbreaks of encephalitis and respiratory disease in Bangladesh and India on a near-annual basis. We determined that a single dose of a lipid nanoparticle nucleoside-modified messenger RNA vaccine encoding the soluble Hendra virus glycoprotein protected up to 70% of Syrian hamsters from lethal NiV challenge, despite animals having suboptimally primed immune responses before challenge. These data provide a foundation from which to optimize future messenger RNA vaccination studies against NiV and other highly pathogenic viruses.

scholarly journals Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine

2021 ◽  
Author(s):  
Christopher L.D. McMillan ◽  
Jovin J.Y. Choo ◽  
Adi Idris ◽  
Aroon Supramaniam ◽  
Naphak Modhiran ◽  
...  
Keyword(s):  
Single Dose ◽  
Immune Responses ◽  
Subunit Vaccine ◽  
High Density ◽  
Complete Protection ◽  
Virus Challenge ◽  
Skin Patch

SARS-CoV-2 has infected over 160 million people and resulted in more than 3.3 million deaths, and we still face many challenges in the rollout of vaccines. Here, we use the high-density microarray patch to deliver a SARS-CoV-2 spike subunit vaccine directly to the skin. We show the vaccine, dry-coated on the patch is thermostable, and delivery of spike via HD-MAP induced greater cellular and antibody immune responses, with serum able to potently neutralize clinically relevant isolates including those from the B.1.1.7 and B.1.351 lineages. Finally, a single dose of HD-MAP-delivered spike provided complete protection from a lethal virus challenge, demonstrating that HD-MAP delivery of a SARS-CoV-2 vaccine is superior to traditional needle-and-syringe vaccination and has the potential to greatly impact the ongoing COVID-19 pandemic.

scholarly journals Single-dose live-attenuated Nipah virus vaccines confer complete protection by eliciting antibodies directed against surface glycoproteins

Vaccine ◽  
2014 ◽  
Vol 32 (22) ◽  
pp. 2637-2644 ◽  
Author(s):  
Blair L. DeBuysscher ◽  
Dana Scott ◽  
Andrea Marzi ◽  
Joseph Prescott ◽  
Heinz Feldmann
Keyword(s):  
Single Dose ◽  
Nipah Virus ◽  
Complete Protection ◽  
Surface Glycoproteins

Single-Dose and Multiple-Dose Pharmacokinetics of Nicotine 6 mg Gum

2016 ◽  
pp. ntw211
Author(s):  
Anna Hansson ◽  
Thomas Rasmussen ◽  
Holger Kraiczi
Keyword(s):  
Single Dose ◽  
Multiple Dose ◽  
Multiple Dose Pharmacokinetics

Single-dose and multiple-dose pharmacokinetics of etintidine in healthy volunteers

1988 ◽  
Vol 34 (1) ◽  
pp. 101-104 ◽  
Author(s):  
S. -M. Huang ◽  
T. B. Marriott ◽  
H. S. Weintraub ◽  
J. D. Arnold ◽  
J. Boccagno ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Volunteers ◽  
Multiple Dose ◽  
Multiple Dose Pharmacokinetics
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