Protection against bovine respiratory syncytial virus challenge following a single dose of vaccine in young calves with maternal antibody

2005 ◽  
Vol 156 (5) ◽  
pp. 139-143 ◽  
Author(s):  
I. C. Mawhinney ◽  
M. R. Burrows
Keyword(s):  
Single Dose ◽  
Respiratory Syncytial Virus ◽  
Bovine Respiratory Syncytial Virus ◽  
Maternal Antibody ◽  
Virus Challenge ◽  
Syncytial Virus

Protection against bovine respiratory syncytial virus in calves vaccinated with adjuvanted modified live vaccine administered in the face of maternal antibody

Vaccine ◽  
2020 ◽  
Vol 38 (2) ◽  
pp. 298-308 ◽  
Author(s):  
Elizabeth A. Kolb ◽  
Robin E. Buterbaugh ◽  
Carol L. Rinehart ◽  
Douglas Ensley ◽  
George A. Perry ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Bovine Respiratory Syncytial Virus ◽  
Live Vaccine ◽  
Maternal Antibody ◽  
The Face ◽  
Syncytial Virus ◽  
Modified Live Vaccine

scholarly journals Recombinant bovine respiratory syncytial virus with deletion of the SH gene induces increased apoptosis and pro-inflammatory cytokines in vitro, and is attenuated and induces protective immunity in calves

2014 ◽  
Vol 95 (6) ◽  
pp. 1244-1254 ◽  
Author(s):  
Geraldine Taylor ◽  
Sara Wyld ◽  
Jean-Francois Valarcher ◽  
Efrain Guzman ◽  
Michelle Thom ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Inflammatory Cytokines ◽  
Bovine Respiratory Syncytial Virus ◽  
Small Airways ◽  
Upper Respiratory Tract ◽  
Virus Challenge ◽  
Syncytial Virus ◽  
Pro Inflammatory Cytokines

Bovine respiratory syncytial virus (BRSV) causes inflammation and obstruction of the small airways, leading to severe respiratory disease in young calves. The virus is closely related to human (H)RSV, a major cause of bronchiolitis and pneumonia in young children. The ability to manipulate the genome of RSV has provided opportunities for the development of stable, live attenuated RSV vaccines. The role of the SH protein in the pathogenesis of BRSV was evaluated in vitro and in vivo using a recombinant (r)BRSV in which the SH gene had been deleted. Infection of bovine epithelial cells and monocytes with rBRSVΔSH, in vitro, resulted in an increase in apoptosis, and higher levels of TNF-α and IL-1β compared with cells infected with parental, wild-type (WT) rBRSV. Although replication of rBRSVΔSH and WT rBRSV, in vitro, were similar, the replication of rBRSVΔSH was moderately reduced in the lower, but not the upper, respiratory tract of experimentally infected calves. Despite the greater ability of rBRSVΔSH to induce pro-inflammatory cytokines, in vitro, the pulmonary inflammatory response in rBRSVΔSH-infected calves was significantly reduced compared with that in calves inoculated with WT rBRSV, 6 days previously. Virus lacking SH appeared to be as immunogenic and effective in inducing resistance to virulent virus challenge, 6 months later, as the parental rBRSV. These findings suggest that rBRSVΔSH may be an ideal live attenuated virus vaccine candidate, combining safety with a high level of immunogenicity.

scholarly journals Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 234
Author(s):  
Sarah Al-Beltagi ◽  
Cristian Alexandru Preda ◽  
Leah V. Goulding ◽  
Joe James ◽  
Juan Pu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Syncytial Virus ◽  
Influenza A Virus ◽  
Broad Spectrum ◽  
Influenza A ◽  
Respiratory Viruses ◽  
Influenza Viruses ◽  
Virus Challenge ◽  
2009 H1n1 ◽  
Syncytial Virus

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of antivirals in use or development for any disease bears testament to the challenges of antiviral development. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus.

Effect of infection with bovine respiratory syncytial virus on pulmonary clearance of an inhaled antigen in calves

2008 ◽  
Vol 69 (3) ◽  
pp. 416-422 ◽  
Author(s):  
Laurel J. Gershwin ◽  
Robert A. Gunther ◽  
William J. Hornof ◽  
Richard F. Larson
Keyword(s):  
Respiratory Syncytial Virus ◽  
Bovine Respiratory Syncytial Virus ◽  
Pulmonary Clearance ◽  
Syncytial Virus

scholarly journals NASYM, a live intranasal vaccine, protects young calves from bovine respiratory syncytial virus in the presence of maternal antibodies

2021 ◽  
Author(s):  
Elena Marzo ◽  
Carlos Montbrau ◽  
Maria‐Carmen Moreno ◽  
Mercè Roca ◽  
Marta Sitjà ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Bovine Respiratory Syncytial Virus ◽  
Maternal Antibodies ◽  
Intranasal Vaccine ◽  
Syncytial Virus

Phylogenetic relationships of Brazilian bovine respiratory syncytial virus isolates and molecular homology modeling of attachment glycoprotein

2006 ◽  
Vol 116 (1-2) ◽  
pp. 30-37 ◽  
Author(s):  
Fernando Rosado Spilki ◽  
Renata Servan Almeida ◽  
Helena Gallichio Domingues ◽  
Regina Celia Freitas D’Arce ◽  
Helena Lage Ferreira ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Homology Modeling ◽  
Phylogenetic Relationships ◽  
Bovine Respiratory Syncytial Virus ◽  
Syncytial Virus ◽  
Molecular Homology ◽  
Virus Isolates

Subgrouping of bovine respiratory syncytial virus strains detected in lung tissue

1996 ◽  
Vol 53 (3-4) ◽  
pp. 253-260 ◽  
Author(s):  
R.S. Schrijver ◽  
F. Daus ◽  
J.A. Kramps ◽  
J.P.M. Langedijk ◽  
R. Buijs ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Lung Tissue ◽  
Bovine Respiratory Syncytial Virus ◽  
Syncytial Virus ◽  
Virus Strains
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