Faculty Opinions recommendation of Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine.

2018 ◽  
Author(s):  
Alan Frazer ◽  
Flavia Carreno
Keyword(s):  
Protein Kinase ◽  
Elongation Factor ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Antidepressant Action

scholarly journals Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity

1993 ◽  
Vol 293 (1) ◽  
pp. 31-34 ◽  
Author(s):  
N T Redpath ◽  
C G Proud
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Elongation Factor ◽  
Total Activity ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor ◽  
Dependent Protein ◽  
Phosphopeptide Mapping

The catalytic subunit of cyclic AMP-dependent protein kinase (PKA) phosphorylated purified calcium/calmodulin-dependent eukaryotic elongation factor-2 (eEF-2) kinase, isolated from rabbit reticulocyte lysates. It maximally incorporated about 1 mol of phosphate/mol of eEF-2 kinase. The Km of eEF-2 kinase for PKA was calculated to be 7 microM. Phosphorylation of eEF-2 kinase by PKA induced calcium-independent activity which amounted to 40-50% of the total activity measured in the presence of calcium. Furthermore, the level of calcium-independent activity induced by phosphorylation by PKA was similar to that induced by the calcium-stimulated autophosphorylation of eEF-2 kinase. Phosphopeptide mapping of eEF-2 kinase labelled by autophosphorylation and by PKA revealed a number of common phosphopeptides. This suggests that PKA may phosphorylate the same site(s) which are phosphorylated autocatalytically and which are responsible for the induction of calcium-independent activity. The possible implications these findings have for the control of translation are discussed.

Virtual screening and experimental validation of eEF2K inhibitors by combining homology modeling, QSAR and molecular docking from FDA approved drugs

2019 ◽  
Vol 43 (48) ◽  
pp. 19097-19106 ◽  
Author(s):  
Wen-Ling Ye ◽  
Liu-Xia Zhang ◽  
Yi-Di Guan ◽  
Wei-Wei Xue ◽  
Alex F Chen ◽  
...  
Keyword(s):  
Experimental Validation ◽  
Elongation Factor ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor ◽  
Dependent Protein ◽  
Approved Drugs ◽  
Fda Approved Drugs

Eukaryotic elongation factor-2 kinase (eEF2K), a calcium/calmodulin-dependent protein kinase, is a potential target for treating cancer.

Calcium/Calmodulin-Dependent Protein Kinase II Involvement in Release of Gonadotropin-Releasing Hormone

1998 ◽  
Vol 67 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Wendy W. Waters ◽  
Pat L. Chen ◽  
Newell H. McArthur ◽  
Pete A. Moreno ◽  
Paul G. Harms
Keyword(s):  
Protein Kinase ◽  
Gonadotropin Releasing Hormone ◽  
Dependent Protein Kinase ◽  
Releasing Hormone ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein
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