scholarly journals A importância da farmacocinética dos concentrados de coagulação do fator VIII E IX no tratamento das hemofilias: uma revisão integrativa da literatura/ The importance of factor VIII and IX coagulation concentrate pharmacokinetics in the treatment of hemophilia: an integrative literature review

2021 ◽  
Vol 7 (12) ◽  
pp. 120799-120811
Author(s):  
Breno Wendell Sousa Bezerra ◽  
Rafael Rezende Perdiza ◽  
Thially Ferreira Jansen ◽  
Thiago Freitas Silva
Keyword(s):  
Literature Review ◽  
Factor Viii ◽  
Viii And Ix

The diagnosis and management of factor VIII and IX inhibitors: a guideline from the UK Haemophilia Centre Doctors' Organization (UKHCDO)

2000 ◽  
Vol 111 (1) ◽  
pp. 78-90 ◽  
Author(s):  
C. R. M. Hay ◽  
T. P. Baglin ◽  
P. W. Collins ◽  
F. G. H. Hill ◽  
D. M. Keeling
Keyword(s):  
Factor Viii ◽  
Diagnosis And Management ◽  
Viii And Ix ◽  
The Uk

Hepatitis C and Pasteurised Factor VIII and IX Concentrates

1995 ◽  
Vol 73 (04) ◽  
pp. 736-737 ◽  
Author(s):  
D Klarmann ◽  
W Kreuz ◽  
G Auerswald ◽  
K Auberger ◽  
H Rabenau ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Factor Viii ◽  
Viii And Ix

scholarly journals The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom Haemophilia Centre Doctors Organisation

2006 ◽  
Vol 133 (6) ◽  
pp. 591-605 ◽  
Author(s):  
Charles R. M. Hay ◽  
S. Brown ◽  
P. W. Collins ◽  
D. M. Keeling ◽  
R. Liesner
Keyword(s):  
United Kingdom ◽  
Factor Viii ◽  
Diagnosis And Management ◽  
The United Kingdom ◽  
Viii And Ix

The argument for using high purity Factor VIII and IX concentrates in haemophilia

2008 ◽  
Vol 16 (4) ◽  
pp. 404-406
Author(s):  
C.A. LEE
Keyword(s):  
Factor Viii ◽  
High Purity ◽  
Viii And Ix

Use of several second generation serological assays to determine the true prevalence of hepatitis C virus infection in haemophiliacs treated with non-virus inactivated factor VIII and IX concentrates

1992 ◽  
Vol 80 (4) ◽  
pp. 514-518 ◽  
Author(s):  
Henry G. Watson ◽  
Christopher A. Ludlam ◽  
Selma Rebus ◽  
Lin Qi Zhang ◽  
John F. Peutherer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Factor Viii ◽  
Second Generation ◽  
Hepatitis C Virus Infection ◽  
True Prevalence ◽  
Viii And Ix

Factor VIII and IX Inhibitors in Hemophilia

2014 ◽  
pp. 82-92
Author(s):  
Meera Chitlur ◽  
Jeanne Lusher
Keyword(s):  
Factor Viii ◽  
Viii And Ix

Leukemia and Hemophilia

PEDIATRICS ◽  
1986 ◽  
Vol 78 (3) ◽  
pp. 544-544
Author(s):  
SINASI OZSOYLU
Keyword(s):  
Factor Viii ◽  
Hemophilia A ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Viii And Ix ◽  
Immune Changes ◽  
Frozen Plasma

To the Editor.— I enjoyed reading the paper by Aronis et al,1 and would like to bring to your attention that we have also recently observed leukemia in two patients with hemophilia A and B, 10 and 1½ years of age, respectively.2 Because commercial factor VIII and IX were not used and only blood, fresh frozen plasma, and plasma were given on a few occasions, it was less likely that AIDS-like immune changes were responsible for the leukemia in our patients.

THE MODE OF ACTION OF PENTOSAN POLYSULPHATE IN PLASMA

1987 ◽  
Author(s):  
S Béguin ◽  
H C Hemker
Keyword(s):  
Factor Viii ◽  
Linear Increase ◽  
Factor Ix ◽  
Factor X ◽  
Heparin Cofactor Ii ◽  
Normal Plasma ◽  
Viii And Ix ◽  
Pentosan Polysulphate ◽  
Lag Times ◽  
Prothrombinase Activity

We developed a method which enables as to compute the course of prothrombinase activity in clotting plasma (H.C. Hemker, G.M. Willems, S. Béguin: Thromb. Haemostas. 56, 9-17, 1986) and used this for a study of the effect of pentosan polysulphate (PPS) on thrombin generation.When added to normal plasma in the concentration range of 0-8 μg/ml PPS induces a linear increase of the pseudo first order decay constant of endogenous thrombin like heparin does, 1 ug of PPS being equivalent to 0.045 Aig of heparin. Contrary to heparin this action is partly (∼ 65%) dependent upon AT III and partly (∼ 35%) upon heparin cofactor II.In normal plasma PPS causes an inhibition of both extrinsic and intrinsic prothrombinase formation. Only in the intrinsic system an increase of the lag time of prothrombinase appearance is observed. Unlike heparin, PPS does not inhibit factor IXa induced thrombin formation neither does it inhibit prothrombinase formation in the presence of preactivated factor VIII. The prolongation of the lag times must therefore be ascribed to inhibition by PPS of the activation of factor VIII.The inhibition of extrinsic prothrombinase formation by PPS increases with progressive dilution of thromboplastin and is not seen in haemophilia A or B plasma. This demonstrates the existance of a factor VIII and IX dependent process in extrinsic coagulation that gains in importance when the potency of factgr VII-tissue factor complex decreases, i.e. the Josso pathway.PPS, but also heparin causes an unexplained increase of prothrombinase action in haemophIIic plasma. The same phenomenon may be expected to exist in normal plasma, be it obscured by a concomitant inhibition. This, together with the incomplete inhibition of factor VIII activation by PPS makes that we cannot use this inhibitor as a means to quantitate the Josso pathway. The best estimate that we can obtain is that, in the presence of 2% thromboplastin, the factor IX dependent activation of factor X contributes more then 20% to prothrombinase generation.

Role of enhanced half-life factor VIII and IX in the treatment of haemophilia

2015 ◽  
Vol 169 (6) ◽  
pp. 768-776 ◽  
Author(s):  
Ali J. Mahdi ◽  
Samya G. Obaji ◽  
Peter W. Collins
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Viii And Ix ◽  
Life Factor
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