Leukemia and Hemophilia

To the Editor.— I enjoyed reading the paper by Aronis et al,1 and would like to bring to your attention that we have also recently observed leukemia in two patients with hemophilia A and B, 10 and 1½ years of age, respectively.2 Because commercial factor VIII and IX were not used and only blood, fresh frozen plasma, and plasma were given on a few occasions, it was less likely that AIDS-like immune changes were responsible for the leukemia in our patients.

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Decreased Helper-Suppressor Cell Ratios Following Treatment with Blood Products: Factor VIII and IX Concentrates and Fresh Frozen Plasma

Scandinavian Journal of Haematology ◽

10.1111/j.1600-0609.1984.tb02587.x ◽

2009 ◽

Vol 33 (S40) ◽

pp. 371-371

Author(s):

M V Ragni ◽

J H Lewis ◽

J A Spero ◽

F A Bontempo ◽

B S Rabin

Keyword(s):

Factor Viii ◽

Suppressor Cell ◽

Fresh Frozen Plasma ◽

Blood Products ◽

Fresh Frozen ◽

Viii And Ix ◽

Frozen Plasma

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Decreased helper/suppressor cell ratios after treatment with factor VIII and IX concentrates and fresh frozen plasma

The American Journal of Medicine ◽

10.1016/0002-9343(84)90775-7 ◽

1984 ◽

Vol 76 (2) ◽

pp. 206-210 ◽

Cited By ~ 13

Author(s):

Margaret V. Ragni ◽

Jessica H. Lewis ◽

Joel A. Spero ◽

Franklin A. Bontempo ◽

Bruce S. Rabin

Keyword(s):

Factor Viii ◽

Suppressor Cell ◽

Fresh Frozen Plasma ◽

Fresh Frozen ◽

Viii And Ix ◽

Frozen Plasma

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The Recovery of Factor VIII from Fresh-Frozen, Indated and Outdated Human Plasma

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648010 ◽

1976 ◽

Vol 36 (01) ◽

pp. 071-077 ◽

Cited By ~ 2

Author(s):

Daniel E. Whitman ◽

Mary Ellen Switzer ◽

Patrick A. McKee

Keyword(s):

Factor Viii ◽

Polyacrylamide Gel Electrophoresis ◽

Sodium Dodecyl ◽

The United States ◽

Fresh Frozen Plasma ◽

Red Cross ◽

Random Samples ◽

Fresh Frozen ◽

Factor Viii Concentrates ◽

Frozen Plasma

SummaryThe availability of factor VIII concentrates is frequently a limitation in the management of classical hemophilia. Such concentrates are prepared from fresh or fresh-frozen plasma. A significant volume of plasma in the United States becomes “indated”, i. e., in contact with red blood cells for 24 hours at 4°, and is therefore not used to prepare factor VIII concentrates. To evaluate this possible resource, partially purified factor VIII was prepared from random samples of fresh-frozen, indated and outdated plasma. The yield of factor VIII protein and procoagulant activity from indated plasma was about the same as that from fresh-frozen plasma. The yield from outdated plasma was substantially less. After further purification, factor VIII from the three sources gave a single subunit band when reduced and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. These results indicate that the approximately 287,000 liters of indated plasma processed annually by the American National Red Cross (ANRC) could be used to prepare factor VIII concentrates of good quality. This resource alone could quadruple the supply of factor VIII available for therapy.

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52 year Male with Haemophila-A; Presented with Scrotal Haematoma: Managed in Resource Constraint Settings - A Case Report

Journal of Shaheed Suhrawardy Medical College ◽

10.3329/jssmc.v10i2.41173 ◽

2019 ◽

Vol 10 (2) ◽

pp. 118-121

Author(s):

Shoaeb Imtiaz Alam ◽

Md Mustafizur Rahman ◽

Ferdoush Rayhan ◽

ASM Farhad Ul Hasan

Keyword(s):

Factor Viii ◽

Good Alternative ◽

Fresh Frozen Plasma ◽

Haemophilia A ◽

Soft Tissue Trauma ◽

Fresh Frozen ◽

Secondary Closure ◽

Tissue Trauma ◽

The Cost ◽

Frozen Plasma

Haemophilia A is an X linked disorder characterized by bleeding manifestations due to deficiency of factor VIII. Administration of factor VIII is the mainstay of treatment in case of bleeding which is very costly. That’s why fresh frozen plasma is a very good alternative in the management of mild to moderate bleeding. Here we present a case of 50 years old male presented to us with traumatic scrotal haematoma who was newly diagnosed with Haemophilia A. As the patient was unable to bear the cost of factor VIII, we managed the patient by transfusing fresh frozen plasma. After raising his activity of factor VIII up to 30% which was adequate for soft tissue trauma, surgical exploration of scrotum was done. Both the testes were found viable. Evacuation of clot was done followed by secondary closure of the wound J Shaheed Suhrawardy Med Coll, December 2018, Vol.10(2); 118-121

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