scholarly journals FUNCTIONAL PROPERTIES OF PLATELET IN CHILDREN WITH IRRITABLE BOWEL DISEASE

2021 ◽  
Vol 11 (2) ◽  
pp. 80-81
Author(s):  
Alexandra Popovicheva ◽  
Andrew Martusevich ◽  
Elvira Fedulova

The aim of the study was to evaluate platelet activation and aggregation in children with irritable bowel disease (IBD), as well as the effect of hyperbaric oxygenation on these processes. Platelet activation and aggregation in artificial shear flow were studied in 120 patients of both sexes aged 6 to 17 years with IBD. In pediatric patients with CD and UC, a significant increase in the activation and aggregation of platelets was revealed under shear flow conditions. The use of hyperbaric oxygen therapy leads to a decrease in the studied processes. It was found that IBD in children is characterized by significant changes in the functional properties of platelets (activation and aggregation processes).

2017 ◽  
Vol 112 ◽  
pp. S238-S239
Author(s):  
Manju Girish Chandran ◽  
Resmi Varghese ◽  
Anoop Jose Thoppil ◽  
Marina Joseph ◽  
Thomas Augustine ◽  
...  

2018 ◽  
Vol 11 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Miguel Carnero-Gregorio ◽  
Alberto Molares-Vila ◽  
Alberte Corbalán-Rivas ◽  
Carlos Villaverde-Taboada ◽  
Carmen Rodríguez-Cerdeira

Author(s):  
Larissa Steigmann ◽  
Celia Sommer ◽  
Hom‐Lay Wang

2019 ◽  
Vol 114 (1) ◽  
pp. S1039-S1039
Author(s):  
Nicholas Hodgeman ◽  
Christian L. Horn ◽  
Angelo Paredes

1996 ◽  
Vol 42 (3) ◽  
pp. 416-419 ◽  
Author(s):  
T P Mulder ◽  
W H Peters ◽  
D A Court ◽  
J B Jansen

Abstract Class Alpha glutathione S-transferases (GST-Alpha) are found in high concentrations in human liver. Increased plasma concentrations of GSTA1-1, the most abundant isoform of GST-Alpha, are a very sensitive marker for hepatocellular leakage. A sandwich-type ELISA was developed, based on a monoclonal antibody specific for human GSTA1-1 and a polyclonal rabbit anti-human GST-Alpha antiserum. The assay is specific for human GSTA1-1, and has a detection limit of 0.04 micrograms/L. The distribution of plasma GSTA1-1 concentrations in 350 blood donors was nearly normalized by logarithmic transformation and an upper normal reference concentration of 5.9 micrograms/L was calculated. Men had significantly higher plasma GSTA1-1 concentrations than women (P <0.0001). In women, but not in men, a significant increase was noted with age (P <0.05). In patients with inflammatory bowel disease (n= 210), gastrointestinal tumors (n= 70), irritable bowel disease (n= 36), or chronic pancreatitis (n= 12), plasma GSTA1-1 concentrations were similar to those of controls. In contrast, plasma GSTA1-1 concentrations were increased to a similar extent as alanine aminotransferase activities in patients with liver disorders (n= 37).


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