scholarly journals UTERINE INVASIVE MOLE WITH MICROSCOPIC OVARIAN DECIDUOSIS

2020 ◽  
pp. 127-128
Author(s):  
Archana N Rijhsinghani
Keyword(s):  
Hydatidiform Mole ◽  
Muscle Layer ◽  
Uterine Muscle ◽  
Invasive Mole

An invasive mole (formerly known as chorioadenoma destruens) is a hydatidiform mole that has grown into the muscle layer of the uterus. Invasive moles can develop from either complete or partial moles, but complete moles become invasive much more often than do partial moles. Because these moles invade into the uterine muscle layer, they require chemotherapy and/ or surgery.

scholarly journals Repeated ultrasound guided local infiltration of methotrexate in persistent gestational trophoblastic disease with myometrial invasion: case series and review of literature

2021 ◽  
Vol 10 (5) ◽  
pp. 2045
Author(s):  
Tamer H. Said ◽  
Yasser Elkerm
Keyword(s):  
Transvaginal Ultrasound ◽  
Hydatidiform Mole ◽  
Case Series ◽  
Myometrial Invasion ◽  
Muscle Layer ◽  
Gestational Trophoblastic Disease ◽  
Local Injection ◽  
Trophoblastic Disease ◽  
Negative Results ◽  
Invasive Mole

Gestational trophoblastic disease is a group of rare tumors that involve abnormal growth of cells inside a woman's uterus. An invasive mole is a hydatidiform mole that has grown into the muscle layer of the uterus. Invasive vesicular moles can develop from either partial or complete moles, but complete moles become invasive much more often than do partial moles. Invasive moles develop in a little less than 20% of women who have had a complete mole evacuated. Treatment of invasive mole is classically by giving systemic chemotherapy. Objectives of current study were to evaluate the effect of repeated local methotrexate injection in treatment of invasive mole. Cases with invasive mole assigned for local injection of 50 mg methotrexate in 10 cm normal saline using local injection in the myometrium under transvaginal ultrasound guidance. Follow up weekly till negative results are obtained. All cases showed rapid decrease of the level of b-hCG level after local injection and showed negative hormone results within 6 weeks after injection. Local methotrexate intra-myometrial local injection therapy has successful results in cases with persistent invasive hydatidiform mole and should be tried before referring them for systemic therapy.

scholarly journals Gestational trophoblastic neoplasia: Retrospective analysis of clinical profile, treatment pattern and outcome

2016 ◽  
Author(s):  
Paramjeet Kaur ◽  
Ashok K. Chauhan ◽  
Anil Khurana ◽  
Yashpal Verma ◽  
Nupur Bansal
Keyword(s):  
High Risk ◽  
Risk Group ◽  
Hydatidiform Mole ◽  
Single Agent ◽  
High Risk Group ◽  
Treatment Pattern ◽  
Gestational Trophoblastic Neoplasia ◽  
Trophoblastic Tumor ◽  
Villous Trophoblast ◽  
Invasive Mole

Background: Gestational trophoblastic disease is a spectrum of cellular proliferation arising from the placental villous trophoblast. Gestational triphoblastic neoplasia (GTN) is a collective term for GTD that invade locally or metastasize. GTD includes hydatidiform mole (complete and partial) and GTN include invasive mole, choricocarcinoma, placental site trophoblastic tumor and epitheliod trophoblastic tumor. Aim: To evaluate clinicopathological profile, treatment pattern and clinical outcome in patients with gestational trophoblastic neoplasia (GTN). Materials and Methods: Twelve cases of gestational trophoblastic neoplasia treated between 2012 to November 2015 in deptt of Radiotherapy – II, PGIMS, Rohtak were evaluated in this retrospective study. Data was analyzed on the basis of age, histopathology, stage, type of treatment received and treatment related toxicities. Disease free survival was estimated. Results: Out of 12 women 7 (58 %) had hydatidiform mole, 4 (33%) invasive mole and 01 (8%) had choriocarcinoma. All the cases were given chemotherapy. Two patients had low risk disease. Among high risk group seven patients had score of less than 7 and five patients had risk score of 7 or higher. Five patients were given single agent methotrexate, seven patients received multidrug regimens. All patients are on regular follow up. One patient (high risk group) expired as she did not receive treatment. Conclusion: GTN are rare and proliferative disorders with proper diagnosis and treatment most of the cases are amenable to treatment with favorable outcome.

scholarly journals A Case of Invasive Mole

2017 ◽  
Vol 12 (2) ◽  
pp. 86-87
Author(s):  
Shahana Ahmed ◽  
Dipti Rani Shaha
Keyword(s):  
Hydatidiform Mole ◽  
The Body ◽  
Emergency Laparotomy ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Partial Hydatidiform Mole ◽  
Normal Limits ◽  
History Of ◽  
Invasive Mole

Invasive mole is a condition where a molar pregnancy, such as a partial hydatidiform mole or complete hydatidiform mole, invades the wall of the uterus, potentially spreading and metastasizing to other parts of the body. Here is a case who presented with history of evacuation for molar pregnancy. She presented with irregular P/V bleeding on and off and after admission silent perforation with massive haemoperitoneum was detected for which emergency laparotomy was done. She recovered and was followed up till her b-hCG levels were within normal limits. As patient presented to us with haemoperitoneum and on laparotomy, there was invasion into whole of the uterus, it could not be saved and hysterectomy was done.Faridpur Med. Coll. J. Jul 2017;12(2): 86-87

scholarly journals Distinct genomic profiles of gestational choriocarcinoma, a unique cancer of pregnant tissues

2020 ◽  
Vol 52 (12) ◽  
pp. 2046-2054
Author(s):  
Seung-Hyun Jung ◽  
Youn Jin Choi ◽  
Min Sung Kim ◽  
Hyeon-Chun Park ◽  
Mi-Ryung Han ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Neutral Loss ◽  
Hydatidiform Mole ◽  
Driver Mutations ◽  
Cancer Genes ◽  
Single Nucleotide ◽  
Gestational Choriocarcinoma ◽  
Whole Exome ◽  
Late Event ◽  
Invasive Mole

AbstractLittle is known about genomic alterations of gestational choriocarcinoma (GC), unique cancer that originates in pregnant tissues, and the progression mechanisms from the nonmalignant complete hydatidiform mole (CHM) to GC. Whole-exome sequencing (20 GCs) and/or single-nucleotide polymorphism microarray (29 GCs) were performed. We analyzed copy-neutral loss-of-heterozygosity (CN-LOH) in 29 GCs that exhibited androgenetic CN-LOHs (20 monospermic, 8 dispermic) and no CN-LOH (one with NLRP7 mutation). Most GCs (25/29) harboring recurrent copy number alterations (CNAs) and gains on 1q21.1-q44 were significantly associated with poor prognosis. We detected five driver mutations in the GCs, most of which were chromatin remodeling gene (ARID1A, SMARCD1, and EP300) mutations but not in common cancer genes such as TP53 and KRAS. One patient’s serial CHM/invasive mole/GC showed consistent CN-LOHs, but only the GC harbored CNAs, indicating that CN-LOH is an early pivotal event in HM-IM-GC development, and CNAs may be a late event that promotes CHM progression to GC. Our data indicate that GCs have unique profiles of CN-LOHs, mutations and CNAs that together differentiate GCs from non-GCs. Practically, CN-LOH and CNA profiles are useful for the molecular diagnosis of GC and the selection of GC patients with poor prognosis for more intensive treatments, respectively.

scholarly journals A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of β-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation

2021 ◽  
Vol 22 ◽  
Author(s):  
Ali Budi Harsono ◽  
Yudi Mulyana Hidayat ◽  
Gatot Nyarumenteng Adhipurnawan Winarno ◽  
Aisyah Shofiatun Nisa ◽  
Firas Farisi Alkaff
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole ◽  
Serum Levels ◽  
Β Hcg ◽  
Invasive Mole ◽  
Rapid Transformation

Invasive mole after partial hydatidiform mole

Placenta ◽  
1992 ◽  
Vol 13 (4) ◽  
pp. A25
Author(s):  
Seiko Iidzuka ◽  
Junko Takada ◽  
Hitoshi Funayana ◽  
Keiichi Isaka ◽  
Masaomi Takayama
Keyword(s):  
Hydatidiform Mole ◽  
Partial Hydatidiform Mole ◽  
Invasive Mole

scholarly journals Uterine Perforation on Invasive Hydatidiform Mole during EMACO Treatment

2016 ◽  
Author(s):  
Bram Pradipta
Keyword(s):  
Hydatidiform Mole ◽  
Broad Ligament ◽  
Posterior Part ◽  
Exploratory Laparotomy ◽  
Recurrent Bleeding ◽  
Uterine Perforation ◽  
Long Term Treatment ◽  
History Of ◽  
Invasive Mole ◽  
The Right

Objective: Improving skill and knowledge to recognize and manage a rare case of uterine perforation on invasive hydatidiform mole. Method: Case report. Result: A 42 years old Indonesian woman, Parity 2 Abortus 2 with history of 2 c-sections and 2 curettage, came with chief complaint of recurrent vaginal bleeding since 4 months before admission. Patient had a history of previous curettage with indication of hydatidiform mole and recurrent bleeding with no histopathology results. On examination we found a vesicular mass with infiltration, destroying the right-front uterine corpus, size 8x6 cm with an internal echo mass. Chest x-ray showed multiple nodules in the lung. The patient, considered as low risk Gestational Trophoblastic Neoplasia patient with FIGO Score of 6, underwent chemotherapy with 2 series of methotrexate . Due to the non-declining level of -hCG, the regimen was added with EMACO. In the process of chemotherapy, the pa-tient’s-hCG declined but then she complained of major abdominal pain. Exploratory laparotomy was performed and we found a mass sized 5x5x5 cm on the right side of the uterus at the broad ligament with a rupture at the posterior part of the mass sized 0.5x0.5 cm. Upon incision of the uterus, we found a mass from the right side protruding to the isthmus of the uterus. Histopathology showed necrosis, blood and chorionic villi in myometrium corresponding to invasive mole. Patient was then given another 5 series of EMACO and her condition was unremarkable during the remaining course of treatment. Conclusion: Invasive mole treatment is determined based on the risk factors. Uterine perforation still occurred in this case regardless of the decreasing hCG level during EMACO treatment. It emphasizes the importance of clinical examination as chemotherapy responsiveness. Long-term treatment can have a good prognosis but good collaboration between the gynecologist and the patient is essential. [Indones J Obstet Gynecol 2014; 3: 162-165] Keywords: EMACO, invasive mole, perforation

scholarly journals Haemoperitonium : A Rare Presentation of Choriocarcinoma

2020 ◽  
Vol 19 (2) ◽  
pp. 57-58
Author(s):  
Adiba Malik ◽  
Shireen Akter Khanom
Keyword(s):  
Mac Protocol ◽  
Hydatidiform Mole ◽  
Lower Abdominal Pain ◽  
Emergency Admission ◽  
The Body ◽  
Rare Presentation ◽  
Normal Delivery ◽  
Gestational Choriocarcinoma ◽  
Invasive Mole ◽  
Operative Findings

Gestational choriocarcinoma is one of the most malignant form of group of tumors with almost 100% cure rate, developes secondary to pregnancy (Normal or ectopic) following hydatidiform mole, miscarriage or even after child birth. This starts within the uterus in the placenta but a tendency to metastasize to other parts of the body. Indicative signs are unexplained heavy and irregular uterine bleeding, raised serum b hCG, non normalization of b hCG following abortion or delivery and if it spreads, signs of metastasis. Our study presents a case of Choriocarcinoma presented with haemoperitonium, who was treated successfully with surgical and medical management. A 25 years lady Para 1+0, age of 3 years, normal delivery had an emergency admission for 2 months amenorrhoea with severe lower abdominal pain, slight vaginal bleeding suspected clinically as ruptured ectopic pregnancy. Ultrasonography suggest Invasive mole with huge peritoneal collection. After sending serum b hCG she was treated surgically and per operative findings were in favour of Choriocarcinoma which was confirmed by histopathological reports. Serum b hCG was raised and she was treated with combination (MAC protocol) chemotherapy. Chatt Maa Shi Hosp Med Coll J; Vol.19 (2); July 2020; Page 57-58

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