“COMPARATIVE EFFICACY OF ENTECAVIR AND TENOFOVIR ALAFENAMIDE IN TREATMENT OF CHRONIC HEPATITIS-B ”

2021 ◽  
pp. 14-16
Author(s):  
Navneet Kumar Dubey ◽  
Ganesh Narayan Jha ◽  
Debarshi Jana
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
P Value ◽  
Comparative Efficacy ◽  
B Virus ◽  
Treatment Naïve ◽  
Medical Intensive Care ◽  
Tenofovir Alafenamide ◽  
Patient Department

Aims:The Aim of study is to compare the efcacy of entecavir with tenofovir alafenamide in treatment of Chronic Hepatitis B patients. Materials and methods: It is a prospective cohort study to compare efcacy of ENTECAVIR and TAF in treatment of Chronic Hepatitis B. Study location was Out Patient Department(OPD), In Patient Department(IPD) and Medical Intensive care unit (MICU) of Dept. of Medicine of DMCH, Laheriasarai. Study duration was 12 months and total 50 individual was in this study. Result: 12% patients of Entecavir and 16% patients of TAF group were presented with HTN; while DM was observed in 4% patients of Entecavir and 8% patients of TAF group. Regarding co-morbidities we found no signicant difference between two groups (p value = >0.05). Hepatitis B virus DNAin the HBeAg positive group was approximately 2 log10 IU/mLhigher than in the HBeAg-negative group. Conclusion: Treatment with antiviral therapy, ETV or TAF, showed potent antiviral activity against HBV and the efcacy of both drugs was comparable.TAF and ETVshowed comparable efcacy and safety in treatment-naïve CHB patients.

Hepatitis B virus reverse transcriptase mutations in treatment Naïve chronic hepatitis B patients

2013 ◽  
Vol 85 (7) ◽  
pp. 1155-1162 ◽  
Author(s):  
Bhupesh Singla ◽  
Anuradha Chakraborti ◽  
Bal Krishan Sharma ◽  
Shweta Kapil ◽  
Yogesh K. Chawla ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Reverse Transcriptase ◽  
Chronic Hepatitis B ◽  
B Virus ◽  
Treatment Naïve

Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naïve patients with chronic hepatitis B

2009 ◽  
Vol 30 (11-12) ◽  
pp. 1150-1158 ◽  
Author(s):  
M. H. NGUYEN ◽  
R. T. GARCIA ◽  
H. N. TRINH ◽  
H. A. NGUYEN ◽  
K. K. NGUYEN ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Dna Polymerase ◽  
Hepatitis B Virus Dna ◽  
B Virus ◽  
Treatment Naïve

High prevalence of tryptophan-truncated S quasispecies in treatment-naïve chronic hepatitis B patients

2021 ◽  
Vol 102 (7) ◽  
Author(s):  
Hui Dong ◽  
Yongqiang Zhu ◽  
Yan Shen ◽  
Shaoqing Xie ◽  
Yungang He ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
High Expression ◽  
Drug Resistant ◽  
Coding Region ◽  
B Virus ◽  
High Prevalence ◽  
Treatment Naïve

Hepatitis B virus surface antigen (HBsAg) encoded by the S gene is highly expressed during the replication cycle of hepatitis B virus (HBV). However, the frequent usage of tryptophan in HBsAg, which leads to a high cost of biosynthesis, is inconsistent with the high expression level of this protein. Tryptophan-truncated mutation of HBsAg, that is, a tryptophan to stop codon mutation resulting in truncated HBsAg, might help to maintain its high expression with lower biosynthetic cost. We aimed to investigate the prevalence of tryptophan-truncated S quasispecies in treatment-naïve patients with chronic hepatitis B (CHB) by applying CirSeq as well as a site-by-site algorithm developed by us to identify variants at extremely low frequencies in the carboxyl terminus of HBsAg. A total of 730 mutations were identified in 27 patients with CHB, varying from seven to 56 mutations per sample. The number of synonymous mutations was much higher than that of nonsynonymous mutations in the reverse transcriptase (RT) coding region and vice versa in the S coding region, implying that the evolutionary constraints on the RT and S genes might be different. We showed that 25 (92.6 %) of 27 patients had at least one S-truncated mutation, most of which were derived from tryptophan, indicating a high prevalence of tryptophan-truncated S mutations in treatment-naïve patients with CHB. In terms of the RT gene, 21 (77.8 %) patients had pre-existing drug-resistant mutations, while no truncated mutations were detected. Our findings that tryptophan-truncated S quasispecies and drug-resistant RT mutants were highly prevalent in treatment-naïve patients with CHB provide new insights into the composition of the HBV population, which might help optimize the treatment and management of patients with CHB.

The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B

2020 ◽  
pp. 1-12
Author(s):  
Habip Gedik ◽  
Muge Sonmezisik
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Partial Response ◽  
Combination Therapy ◽  
Chronic Hepatitis B ◽  
Antiviral Drug ◽  
Sustained Viral Response ◽  
Treatment Naïve ◽  
Tenofovir Alafenamide ◽  
Partial Virological Response

Abstract We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the Department of Infectious Diseases and Clinical Microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in naïve patients with a partial response to TDF monotherapy. Keywords: Chronic hepatitis B, Tenofovir, partial response, Entecavir, combination therapy

Comparison of Clevudine and Entecavir for Treatment-naive Patients With Chronic Hepatitis B Virus Infection

2011 ◽  
Vol 45 (10) ◽  
pp. 893-899 ◽  
Author(s):  
Eileen L. Yoon ◽  
Hyung Joon Yim ◽  
Hyun Jung Lee ◽  
Young Sun Lee ◽  
Jeong Han Kim ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Treatment Naïve

scholarly journals Pre-Existing Mutations in Reverse Transcriptase of Hepatitis B Virus in Treatment-Naive Chinese Patients with Chronic Hepatitis B

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0117429 ◽  
Author(s):  
Jie Xu ◽  
Biao Wu ◽  
Jing-Hui Wang ◽  
Ling Huang ◽  
Deng-yu Wang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Reverse Transcriptase ◽  
Chronic Hepatitis B ◽  
Chinese Patients ◽  
B Virus ◽  
Treatment Naïve
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