scholarly journals Intra Nasal Midazolam vs. Rectal Diazepam in Management of Acute Seizures in Pediatrics, Considering the Antiepileptic Drugs Monitoring

2021 ◽  
Vol 83 ◽  
Author(s):  
JIAN JIAO ◽  
XINLU ZUO ◽  
NA LIU ◽  
JI WANG ◽  
AIDONG ZHANG ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Acute Seizures ◽  
Rectal Diazepam

Pharmacoeconomic Considerations in Treatment Options for Acute Seizures

1998 ◽  
Vol 13 (1_suppl) ◽  
pp. S27-S29 ◽  
Author(s):  
Nina Graves
Keyword(s):  
Treatment Options ◽  
Emergency Department Visits ◽  
Event Management ◽  
Pharmacoeconomic Data ◽  
Acute Seizures ◽  
Rectal Diazepam ◽  
Adverse Event Management ◽  
History Of ◽  
Cluster Seizures ◽  
The Cost

Two pharmacoeconomic studies on the treatment of acute seizures have been conducted. In 1991, Kriel and colleagues surveyed parents of children with a history of cluster seizures, prolonged seizures, or status epilepticus who had been instructed in the use of rectal diazepam. A comparison of data before instruction with data after instruction showed a reduced need for emergency department visits with rectal diazepam. Instruction thus provided a pharmacoeconomic benefit, despite the cost of the product. In 1996, Marchetti and coworkers found that intravenous fosphenytoin was associated with fewer adverse events than intravenous phenytoin. Fosphenytoin thus reduced the need for adverse event management and provided a substantial pharmacoeconomic benefit, despite its higher cost, compared with phenytoin. This study had a number of limitations, however, and hospital pharmacists remain resistant to the use of fosphenytoin. Additional studies may provide more pharmacoeconomic data to support the greater use of fosphenytoin in the treatment of acute pediatric seizures. (J Child Neurol 1998;13(Suppl 1):S27-S29).

scholarly journals Long-term retention rates of antiepileptic drugs used in acute seizures

Seizure ◽  
2018 ◽  
Vol 61 ◽  
pp. 78-82 ◽  
Author(s):  
Manuel Toledo ◽  
Elena Fonseca ◽  
Marta Olivé ◽  
Manuel Requena ◽  
Manuel Quintana ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Retention Rates ◽  
Acute Seizures ◽  
Term Retention ◽  
Long Term Retention

scholarly journals The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs

2019 ◽  
Vol 13 ◽  
Author(s):  
Hanno Heuzeroth ◽  
Matthias Wawra ◽  
Pawel Fidzinski ◽  
Ramazan Dag ◽  
Martin Holtkamp
Keyword(s):  
Antiepileptic Drugs ◽  
Acute Seizures ◽  
New Antiepileptic Drugs

scholarly journals Intranasal Midazolam vs Rectal Diazepam for the Home Treatment of Acute Seizures in Pediatric Patients With Epilepsy

2010 ◽  
Vol 164 (8) ◽  
Author(s):  
Maija Holsti ◽  
Nanette Dudley ◽  
Jeff Schunk ◽  
Kathleen Adelgais ◽  
Richard Greenberg ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Home Treatment ◽  
Acute Seizures ◽  
Rectal Diazepam ◽  
Patients With Epilepsy ◽  
Intranasal Midazolam

scholarly journals Treatment of Acute Seizures: Is Intranasal Midazolam a Viable Option?

2013 ◽  
Vol 18 (2) ◽  
pp. 79-87 ◽  
Author(s):  
Lesley K. Humphries ◽  
Lea S. Eiland
Keyword(s):  
Pediatric Population ◽  
Cost Effective ◽  
Standard Of Care ◽  
Kinetic Properties ◽  
Viable Option ◽  
Safe Alternative ◽  
Acute Seizures ◽  
Recent Interest ◽  
Rectal Diazepam ◽  
Intranasal Midazolam

Seizures in the pediatric population commonly occur, and when proper rescue medication is not administered quickly, the risk of neurologic compromise emerges. For many years, rectal diazepam has been the standard of care, but recent interest in a more cost-effective, safe alternative has led to the investigation of intranasal midazolam for this indication. Although midazolam and diazepam are both members of the benzodiazepine class, the kinetic properties of these 2 anticonvulsants vary. This paper will review available data pertaining to the efficacy, safety, cost, and pharmacokinetics of intranasal midazolam versus rectal diazepam as treatment for acute seizures for children in the prehospital, home, and emergency department settings.

PO18-WE-40 Buccal midazolam compared to rectal diazepam and intravenous midazolam as emergent treatment of acute seizures in children: preliminary study

2009 ◽  
Vol 285 ◽  
pp. S254-S255 ◽  
Author(s):  
M.L.M. Trajano ◽  
B.C. Sanchez ◽  
M.B. Lukban ◽  
A.M. Salonga
Keyword(s):  
Acute Seizures ◽  
Rectal Diazepam ◽  
Preliminary Study

scholarly journals Comparison of Intranasal Midazolam and Rectal Diazepam as Anticonvulsant in Children

2016 ◽  
Vol 35 (2) ◽  
pp. 117-122
Author(s):  
Prastiya Indra Gunawan ◽  
Fadil Rulian ◽  
Darto Saharso
Keyword(s):  
Time Interval ◽  
Onset Of Action ◽  
Interval Time ◽  
Rank Analysis ◽  
Acute Seizures ◽  
Standard Management ◽  
Rectal Route ◽  
Rectal Diazepam ◽  
Significant Difference ◽  
Intranasal Midazolam

Introduction: Rectal diazepam is reputed as the gold-standard management of childhood seizures. Otherwise, intranasal (IN) midazolam has no first-pass metabolism and faster onset of action. The effectiveness and easier route of these drugs are important choices for faster seizure cessation. The aim of this study was to clarify the effectiveness of intranasal midazolam compared with rectal diazepam for seizure termination.Material and Methods: The children, one month until 18 years of age, presented with acute seizures. Patients were randomly classified into two groups with either received intranasal midazolam or rectal diazepam for seizure termination. Interval time of drug administration to cease seizure was compared. The log-rank analysis was used for statistical analysis. Side effect of both drugs were evaluated.Results: There were 60 patients enrolled the study, 30 in each group. The median time interval for seizures cessation with intranasal midazolam was 42 seconds, otherwise in rectal diazepam group was 180 seconds. There was statistically significant difference interval time between two groups (p<0.01). None of the both groups had any significant side effects statistically.Conclusion: Intranasal midazolam is effective to terminate a seizure in children. It can be used as an alternative treatment for seizures in patients with intravenous or rectal route difficulties.J Nepal Paediatr Soc 2015;35(2):117-122  

IV Levetiracetam Aided Newborns With Acute Seizures

2011 ◽  
Vol 7 (3) ◽  
pp. 14
Author(s):  
DIANA MAHONEY
Keyword(s):  
Acute Seizures
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