TREATMENT OF RECURRENT HERPES VIRUS INFECTION: STANDARD APPROACHES AND NEW PERSPECTIVES

Chronic recurrent herpes virus infection is a major problem of modern health care, not only due to its wide distribution among the reproductive age population, but also due to the complexity of the control of this disease, in spite of modern treatment methods. This situation is a result of the development of so called «vicious circle» - the severity of herpes virus infection depends on the degree of immunosuppression and on the nature of immune system disorders caused by immunosuppressive properties of the virus. Understanding of the pathogenesis of the disease and especially local and systemic immune response helps to shape immunopathogenetic approach to therapy of herpes virus infection. Study of immunomodulator Laennek® («Japan Bioproducts Co., Ltd», Japan) efficacy as adjuvant therapy of chronic recurrent viral infection caused by the herpes simplex viruses type 1, 2 showed good results.

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Generalized neonatal herpes virus infection (cytomegalovirus or herpes virus type 1) comparative examination of loci attacked by two viruses3,4

Pathology International ◽

10.1111/j.1440-1827.1984.tb07613.x ◽

1984 ◽

Vol 34 (4) ◽

pp. 847-858

Author(s):

Kishichiro Watanabe ◽

Junji Tanaka ◽

Motoichi Hatano ◽

Isao Nakanishi ◽

Mikio Mukai ◽

...

Keyword(s):

Virus Infection ◽

Virus Type ◽

Herpes Virus ◽

Neonatal Herpes ◽

Herpes Virus Infection ◽

Herpès Virus ◽

Comparative Examination

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Recurrent herpes virus infection: the strategy of antiviral therapy

Klinicheskaya dermatologiya i venerologiya ◽

10.17116/klinderma201514329-36 ◽

2015 ◽

Vol 14 (3) ◽

pp. 29 ◽

Cited By ~ 1

Author(s):

A. E. Shul’zhenko ◽

I. N. Zuykova ◽

R. V. Shchubelko

Keyword(s):

Virus Infection ◽

Antiviral Therapy ◽

Herpes Virus ◽

Herpes Virus Infection ◽

Recurrent Herpes ◽

Herpès Virus

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High-throughput sequencing in diagnostics and prevention of herpes simplex virus infection (Herpesviridae, Alphaherpesvirinae, Simplexvirus, Human alphaherpesvirus 1)

Voprosy Virusologii ◽

10.36233/0507-4088-2020-65-3-126-131 ◽

2020 ◽

Vol 65 (3) ◽

pp. 126-131

Author(s):

O. V. Sergeyev ◽

R. E. Bosh’ian ◽

I. F. Barinsky

Keyword(s):

Herpes Simplex ◽

Virus Infection ◽

High Throughput ◽

Herpes Virus ◽

High Throughput Sequencing ◽

Clinical Manifestations ◽

Primer Binding Site ◽

Herpes Virus Infection ◽

Herpes Simplex Viruses ◽

Herpès Virus

Herpes simplex viruses types 1 (HSV-1) and 2 (HSV-2) are among the most common viruses in the human population. The clinical manifestations of HSV infection vary widely, which necessitates reliable molecular methods for the timely diagnosis of herpes virus infection, as well as for detection of mutations in the genes responsible for drug resistance. PCR is often unable to detect HSV isolates with nucleotide substitutions at the primer binding site. Sanger sequencing of the whole genome reveals mutations mainly at the consensus level, which accumulate at advanced stages of viral infection. High-throughput sequencing (HTS, next generation sequencing) offers an obvious advantage both in early diagnosis of herpes virus infection and identification of HSV variants.

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