Evaluation of association of relevant past history, symptoms, signs, complication profile and sero prevalence of HBV and HCV among the patients presenting with chronic liver disease and its complications: A Tertiary Care Hospital Based Study

2020 ◽  
pp. 9-18
Author(s):  
Richmond Ronald Gomes ◽  
Akmat Ali
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Health Problem ◽  
Tertiary Care ◽  
Chronic Liver ◽  
Care Hospital ◽  
Major Health

Background: Now-a-days chronic liver disease is one of the major health problems in the world. In developing countries, chronic liver disease due to hepatitis virus (like hepatitis B and hepatitis C virus) is increasing day by day. It is rapidly emerging as a major health problem. So the present study was conducted to document the hepatitis B and hepatitis C virus in patient with chronic liver disease by an easy and simple marker like HBsAg, Anti HBc (total) and Anti HCV in a tertiary hospital. Methods: Serum samples were collected from 100 selected cases who were diagnosed as a case of chronic liver disease in medicine and gastroenterology department of DMCH. Study period was from April 01, 2016 to September 30, 2018. For detection of HBsAg, Anti HBc (total) and Anti HCV, Immunochromatographic test (ICT) was done in every case. Results: Out of 100 cases, HBsAg seropositive with negative Anti HCV was found in 64% cases, Anti HCV positive with negative HBsAg was found in 16% cases, both HBsAg and anti HCV positive was found in 4% cases, both HBsAg and anti HCV negative was found in 16% cases. Among these cases, 74% were male and 26% were female. Here male: female was 3:1 and among them, 75% male was seropositive for either HBsAg or Anti HCV. Conclusion: The high frequency of seropositivity in patients with chronic liver disease with male predominance is found in tertiary care settings. The number of Anti HCV seropositive patient indicates that it is an emerging health problem in our country. Keywords: Chronic liver disease; HBsAg; Anti HCV; ICT

scholarly journals Chronic Liver Disease in Ethiopia with a Particular Focus on the Etiological Spectrums: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Behailu Terefe Tesfaye ◽  
Temesgen Mulugeta Feyissa ◽  
Azmeraw Bekele Workneh ◽  
Esayas Kebede Gudina ◽  
Mengist Awoke Yizengaw
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Meta Analysis ◽  
Chronic Liver ◽  
B Virus

Background. In Ethiopia, chronic liver disease (CLD) is the 7th leading cause of death, accounting for about 24 deaths per 100000 populations in 2019. Despite its burden, there is a lack of compiled pieces of evidence on CLD in the country. Thus, this systematic review and meta-analysis is intended to provide the pooled estimates of CLD etiologies and mortality rate in CLD patients in Ethiopia. Method. PubMed, Google Scholar, ScienceDirect, institutional repositories, national digital library, and the bibliography of the eligible articles information were the source of data for the present review. The keywords “hepatitis, chronic” [Mesh], “end-Stage Liver Disease” [Mesh], “chronic liver disease”, “liver cirrhosis” [Mesh], and “Ethiopia” were used for the searches. Overall, we retrieved 199 records and 12 were included in this review. We used the DerSimonian-Laird random-effects models to perform the meta-analysis. We conducted subgroup and meta-regression analyses to account for the heterogeneity of the estimates. Result. Hepatitis B virus, alcohol, and hepatitis C virus are the three most common etiologies of CLD in Ethiopia accounting for a pooled estimate of 40.0% [95% CI: 29.0, 51.0, I2 = 96.3, p < 0.001 ], 17.0% [95% CI: 9.0, 25.0, I2 = 96.7, p < 0.001 ], and 15.0% [95% CI: 9.0, 21.0, I2 = 95.8, p < 0.001 ], respectively. Unidentified etiology report has a substantial contribution accounting for an estimated pooled proportion of 45% [95% CI: 34.0, 56.0%, Q = 32.08, p < 0.001 , I2 = 87.53] of the CLD cases in the country. On the other hand, the overall hospital mortality rate in CLD patients is 25.0% [95% CI: 2.0, 47.0, I2 = 94.6, p < 0.001 ] in Ethiopia. Conclusion. Hepatitis B virus, hepatitis C virus, and alcohol are the three most common contributors to CLD cases in Ethiopia. The authors warrant routine screening and strengthening of preventive and treatment programs for viral hepatitis B and C, further enhancing the alcohol policy of the country.

Hepatitis B vaccination in patients with chronic liver disease secondary to hepatitis C virus infection (CLDC)

2002 ◽  
Vol 36 ◽  
pp. 229
Author(s):  
Cristiane Both ◽  
Eliana Gomes ◽  
Claudio Alexandre ◽  
Jose Remiao ◽  
Gabriela Coral ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis B Vaccination ◽  
Hepatitis C Virus Infection

Hematological, Biochemical and Etiological factors of Chronic Liver Disease in a tertiary care Hospital of Lahore

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Sami Ullah Mumtaz ◽  
Amna Akbar ◽  
Humaira Waseem ◽  
Tayyeba Komal ◽  
Somia Iqtadar ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatic Encephalopathy ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Chronic Liver ◽  
Care Hospital ◽  
Alcoholic Fatty Liver ◽  
Etiological Factors

Chronic Liver Disease (CLD) progresses from hepatocyte inammation to brosis, regeneration, cirrhosis and in some cases to Hepatocellular Carcinoma (HCC). In general, the main etiologies of Liver Cirrhosis (LC) are viral infections (hepatitis C and B viruses), chronic alcohol abuse and Non-Alcoholic Fatty Liver Disease (NAFLD), including Non-Alcoholic Steato Hepatitis (NASH). Major complications of CLD are ascites, upper gastrointestinal bleeding, jaundice (acute or chronic) and hepatic encephalopathy. Abstract:Study Design: Cross-sectional.Conclusions: This study assesses the etiological factors and complications of CLD in a tertiary care hospital of Lahore, Pakistan. Objectives: Methods: Study was carried out in indoor and Accident & Emergency Departments of Mayo Hospital Lahore. 100 clinically diagnosed CLD cases were chosen through “Convenient Sampling” technique during 3 months. Observations: Most common complications of CLD were upper GI variceal Bleeding (48%) & hepatic encephalopathy (34%) and acute or chronic hepatitis (AVH) (33%). Other less common complications observed were hepatorenal syndrome (10%), Spontaneous bacterial peritonitis (15%), Ascites (5%) and HCC (10%). Hepatitis C was found as main etiological factor of CLD. Bleeding and hepatic encephalopathy are the common complications. Awareness programmes regarding CLD and its complications are mandatory in our society to improve human health.

scholarly journals Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease

Intervirology ◽  
2008 ◽  
Vol 51 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Mikako Obika ◽  
Toshiyuki Shinji ◽  
Shin-ichi Fujioka ◽  
Ryo Terada ◽  
Hiromasa Ryuko ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Liver Tissue ◽  
Chronic Liver ◽  
Hepatitis B Virus Dna ◽  
B Virus
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