Trimetazidine may normalize left ventricular systolic function and U wave polarity in severe calcific aortic stenosis

Left Ventricular ◽

Metabolic Effects ◽

Ventricular Ejection Fraction ◽

Valvular Aortic Stenosis

A case of severe calcific valvular aortic stenosis with reduced left ventricular ejection fraction is presented. Patient did not agree for surgery. He was advised trimetazidine (60 mg twice a day) in addition to Torsemide, Digoxin, Aspirin and Clopidogrel. After one month, patient showed significant improvement in symptoms, normalization of U waves in electrocardiogram and significant improvement in ejection fraction. Metabolic effects of trimetazidine could be responsible for improvement in left ventricular function in spite of no change in aortic stenosis. Keywords: Aortic valve stenosis; Electrocardiography; Left ventricular systolic function; Trimetazidine; U wave

342 Feasibility and Accuracy of Assessing Left Ventricular Systolic Function by Measuring Left Ventricular Ejection Fraction Using a Hand-held Echocardiography Device With an Automated Algorithm

Heart Lung and Circulation ◽

10.1016/j.hlc.2020.09.349 ◽

2020 ◽

Vol 29 ◽

pp. S187

Author(s):

K. Guppy-Coles ◽

M. Johnstone ◽

S. Prasad ◽

K. Smith ◽

A. Lo ◽

...

Keyword(s):

Ejection Fraction ◽

Systolic Function ◽

Left Ventricular ◽

Ventricular Ejection Fraction ◽

Automated Algorithm ◽

Hand Held Echocardiography

IMPACT OF FLOW AND LEFT VENTRICULAR SYSTOLIC FUNCTION ON OUTCOME OF PATIENTS WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION AND LOW GRADIENT SEVERE AORTIC VALVE STENOSIS UNDERGOING AORTIC VALVE REPLACEMENT

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)62012-x ◽

2014 ◽

Vol 63 (12) ◽

pp. A2009

Author(s):

Vasileios Kamperidis ◽

Philippe J. van Rosendael ◽

Arnold C.T. Ng ◽

Spiros Katsanos ◽

F. van der Kley ◽

...

Keyword(s):

Aortic Valve ◽

Ejection Fraction ◽

Aortic Valve Replacement ◽

Systolic Function ◽

Left Ventricular ◽

Ventricular Ejection Fraction

Validation of Estimating Left Ventricular Ejection Fraction by Mitral Annular Displacement Derived From Speckle-Tracking Echocardiography: A Neglected Method for Evaluating Left Ventricular Systolic Function

10.22541/au.159569146.69948877 ◽

2020 ◽

Author(s):

Yonghuai Wang ◽

Shuang Liu ◽

Jun Li ◽

Yan Zhang ◽

Guangyuan Li ◽

...

Keyword(s):

Ejection Fraction ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Systolic Function ◽

Left Ventricular ◽

Ventricular Ejection Fraction

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

Cardiology ◽

10.1159/000368392 ◽

2015 ◽

Vol 130 (2) ◽

pp. 91-95

Author(s):

Yang Liu ◽

Manasi Bapat ◽

Haroon Kamran ◽

Louis Salciccioli ◽

Anna Rozenboym ◽

...

Keyword(s):

Ejection Fraction ◽

Systolic Function ◽

Ankle Brachial Index ◽

Left Ventricular ◽

Ventricular Ejection Fraction ◽

Bonnet Macaques

Low ankle-brachial index (ABI) is a marker of peripheral arterial disease associated with higher cardiovascular risk. ABI has been found to be influenced by left ventricular ejection fraction (LVEF), but this relation is confounded by atherosclerosis. Objectives: Since nonhuman primates have a low incidence of atherosclerosis, we sought to evaluate the effect of LVEF on ABI in 24 healthy female bonnet macaques (age 83 ± 21 months). Methods: LVEF was determined by echocardiography during anesthesia with ketamine. ABI was determined using automatic blood pressure cuff. Results: Mean LVEF was 73 ± 6%. Mean ABI was 1.03 (range 0.78-1.17) with similar right and left lower limb values (p = 0.78). On univariate analysis, mean ABI was significantly correlated with LVEF (r = 0.58, p = 0.003) but not with age, crown-rump length or weight. Mean LVEF increased in a stepwise manner from lowest to highest ABI tertile (68 ± 6 vs. 73 ± 4 vs. 77 ± 5%, p = 0.008). On ordinal regression and forced multivariate linear analyses, ABI status was independently related to LVEF. Conclusions: ABI is influenced by left ventricular systolic function but not age, height, weight or mass index in bonnet macaques. Left ventricular systolic function should be accounted for when considering ABI measurements.