scholarly journals Age-related differences in the symmetry of electromyographic activity and muscle force in lower limbs

2019 ◽  
Vol 21 (4) ◽  
Author(s):  
Agnieszka Szpala
Keyword(s):  
Muscle Force ◽  
Lower Limbs ◽  
Electromyographic Activity ◽  
Age Related

scholarly journals Clinical and Electromyographic Examinations of Patients with Essential Tremor

2000 ◽  
Vol 27 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Ivan Milanov
Keyword(s):  
Essential Tremor ◽  
Neurological Examination ◽  
Lower Limbs ◽  
Electromyographic Activity ◽  
Parkinsonian Tremor ◽  
Historical Aspects ◽  
Rest Tremor ◽  
Different Types ◽  
Antagonistic Muscles ◽  
Alt Activity

ABSTRACT:Background:It is believed that no clinical differences exist among essential, familial and senile tremor, or between the tremor with synchronous or alternating electromyographic activity. The aim of this study was to evaluate the clinical and electromyographic findings in a large group of patients with different types of essential tremor.Methods:Two hundred and twenty patients with sporadic, familial or senile variants of essential tremor were examined. According to the electromyographic activity recorded from the antagonistic muscles, the patients were subdivided into a group with synchronous (SYN) and a group with alternating (ALT) activity. The historical aspects of the disease were noted, and a detailed neurological examination was performed.Results:A widespread tremor involving upper and lower limbs and 3-4 different anatomical regions was typical for familial tremor. It also had higher amplitude than the sporadic and senile tremor. ALT tremor had a higher amplitude and longer burst duration than SYN and more often involved lower limbs. Rest tremor was common in the ALT group. Overall, ALT tremor was more common than previously supposed.Conclusion:The familial and ALT tremors are more disabling than other types of essential tremor. Since electromyographic ALT activity is common in essential tremor, its presence does not reliably distinguish essential and Parkinsonian tremor.

Electromyographic Activity of Lower Limbs to Stop Baseball Batting

2012 ◽  
Vol 26 (6) ◽  
pp. 1461-1468 ◽  
Author(s):  
Hiroki Nakata ◽  
Akito Miura ◽  
Michiko Yoshie ◽  
Kazutoshi Kudo
Keyword(s):  
Lower Limbs ◽  
Electromyographic Activity

scholarly journals Association between musculoskeletal function deterioration and locomotive syndrome in the general elderly population: A Japanese cohort survey randomly sampled from a basic resident registry

2020 ◽  
Author(s):  
Ryosuke Tokida ◽  
Shota Ikegami ◽  
Jun Takahashi ◽  
Yoshikazu Ido ◽  
Ayaka Sato ◽  
...  
Keyword(s):  
Physical Function ◽  
Age Groups ◽  
Knee Extension ◽  
Lower Limbs ◽  
Locomotive Syndrome ◽  
Knee Extension Strength ◽  
Japanese Cohort ◽  
Age Related ◽  
Musculoskeletal Function ◽  
Stage 1

Abstract Background: Locomotive syndrome (LoS) is defined as the loss of mobility due to age-related impairment of motor organs. The purpose of this study was to evaluate the prevalence and severity of LoS, muscular strength and balancing ability, and prevalence of sarcopenia in relation to the presence of LoS according to sex and age groups ranging between 50-89 years.Methods: Male and female participants between the ages of 50-89 were randomly selected in the resident registry of a cooperating town. Calls for participation continued until approximately 50 consenting participants were successfully recruited for each age group and sex. A total of 413 participants (203 male and 210 female) were enrolled for undergoing a LoS risk test and measuring their physical function. Physical function was compared to participants with or without LoS.Results: A total of 312 patients (75.5%) were diagnosed as LoS, of which 144 (46.2%) were male and 168 (53.8%) were female. The severity of LoS for the 312 patients were 210 (67.3%) for stage 1 and 102 (32.7%) for stage 2. The prevalence of LoS in males were 37%, 59%, 91%, and 100% in the 50s, 60s, 70s, and 80s age strata, respectively. The prevalence of LoS in females were 71%, 62%, 89%, and 98% in the 50s, 60s, 70s, and 80s age strata, respectively. The prevalence of sarcopenia was significantly higher as the age strata in males grew higher. Knee extension strength was significantly lower for participants in their 50s and females in addition to females in their 60s with LoS. The 31 patients diagnosed as sarcopenia included 29 (93.5%) with LoS, 11 (35.4%) classified as LoS stage 1, and 18 (58.1%) classified as stage 2.Conclusions: The prevalence of LoS was high in participants over 70 years of age. In males, the prevalence of sarcopenia was higher as the age strata grew higher. Patients with LoS exhibited lower knee extension strength. We believe that some measures to prevent or improve LoS may require exercise to increase the muscle strength of the lower limbs.

Photopenic Lesions in Bone Marrow Scintigraphy Using Technetium-99m Labeled Antigranulocyte Antibody without Known Tumour

1999 ◽  
Vol 38 (03) ◽  
pp. 85-89 ◽  
Author(s):  
M. Reinhardt ◽  
E. Nitzsche ◽  
E. Moser ◽  
Th. Krause
Keyword(s):  
Bone Marrow ◽  
Unknown Origin ◽  
Axial Skeleton ◽  
Tracer Uptake ◽  
Lower Limbs ◽  
Whole Body ◽  
Bone Marrow Scintigraphy ◽  
Age Related ◽  
Defect Pattern ◽  
Marrow Expansion

Summary Aim: The purpose of this study was to elucidate the frequency of photopenic lesions in patients without known tumour disease by using bone marrow scintigraphy with Tc-99m labeled anti-NCA-95. Methods: Whole body immunoscintigraphy (IS) was performed in 141 consecutive patients with fever of unknown origin. The age ranged between 20 and 88 years with a mean age of 57 years. None of the patients had known tumour disease. Scans were evaluated with respect to photopenic lesions and to bone marrow distribution. Results: IS showed bone marrow defects in the axial skeleton in 16 patients (11 %). With the help of the typical scintigraphic defect pattern, the cause of the lesions was clearly identified as degenerative changes in four patients and in one patient as due to prior sternotomy. In the remaining 11 patients the origin of the defects became evident when the case history or additional imaging was consulted. The mean age of these 16 patients was 69 years ranging from 50 to 88 years. There was an age-related frequency of defects. 10% of the patients from 50 to 59 years showed defects, 60-69 years 9%, 70-79 years 30%, and 33% of the patients from 80 to 89 years had defects. IS was not hampered by tracer uptake to liver or spleen in 93 patients. Left caudal ribs were obscured in 48 patients with intense tracer uptake to the spleen. No or markedly reduced tracer uptake was found in caput humeri and caput femori in 94 and 82 patients, respectively. Patchy tracer uptake to the bone marrow of the limbs was seen in 13/62 patients showing marrow expansion in the lower limbs and 14/55 with marrow expansion in the upper limbs. The patchy pattern was asymmetric in 12 of these patients. Conclusion: The results of the present study reveal that using Tc-99m NCA-95, photopenic lesions of the bone marrow are rarely seen in patients without known malignant disease. The occurrence of benign lesions is age-related. The benign cause of the lesion was obvious from location and pattern of the lesion in about 30% of the cases. Evaluation of lesions in the upper and lower limbs may be hindered due to physiological variation of marrow distribution. Nevertheless, IS appears to be well-suited for the detection and localization of bone marrow metastases.

Age-related differences in corticospinal excitability and inhibition during coordination of upper and lower limbs

2012 ◽  
Vol 33 (7) ◽  
pp. 1484.e1-1484.e14 ◽  
Author(s):  
Hakuei Fujiyama ◽  
Mark R. Hinder ◽  
Matthew W. Schmidt ◽  
Michael I. Garry ◽  
Jeffery J. Summers
Keyword(s):  
Corticospinal Excitability ◽  
Lower Limbs ◽  
Age Related

scholarly journals Age-related changes of human serum Sirtuin6 in adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ying Zhao ◽  
Xiangli Bai ◽  
Xiong Jia ◽  
Yajing Lu ◽  
Wenzhuo Cheng ◽  
...  
Keyword(s):  
Serum Level ◽  
Histone Deacetylases ◽  
Pearson Correlation ◽  
Serum Levels ◽  
Lower Limbs ◽  
Human Beings ◽  
Human Telomerase Reverse Transcriptase ◽  
Real Time Quantitative Pcr ◽  
Age Related ◽  
Human Telomerase

Abstract Background Aging is a natural life process and with an aging population, age-related diseases (e.g. type 2 diabetes mellitus (T2DM), atherosclerosis-based cardiovascular diseases) are the primary mortality cause in older adults. Telomerase is often used as an aging biomarker. Detection and characterization of novel biomarkers can help in a more specific and sensitive identification of a person’s aging status. Also, this could help in age-related diseases early prevent, ultimately prolonging the population’s life span. Sirtuin 6 (Sirt6) - a member of the Sirtuins NAD+-dependent histone deacetylases family - is mainly intracellularly expressed, and is reported to be involved in the regulation of aging and aging-related diseases. Whether serum Sirt6 is correlated with aging and could be used as an aging biomarker is unknown. In the present study, we aimed to investigate the age-related Sirt6 changes in the serum of human adults. Methods Participants were divided into three groups according to age: 20–30 years (Young); 45–55 years (Middle-aged); and ≥ 70 years (Old). The Sirt6 and telomerase serum concentrations were determined by ELISA. The Sirt6 and human telomerase reverse transcriptase (hTERT) expression in vessels from amputated human lower limbs were analyzed using real-time quantitative PCR (RT-qPCR) and immunohistochemical staining. The relationships between variables were evaluated by Pearson correlation analysis. Results The Sirt6 and telomerase serum levels reduced with an increase in age. A similar tendency was observed for Sirt6 and hTERT in the vessel. Serum levels of Sirt6 were higher in females compared with males. Pearson’s regression analysis revealed that the Sirt6 serum level positively correlated with telomerase (r = 0.5743) and both were significantly negatively correlated with age (r = − 0.5830 and r = − 0.5993, respectively). Conclusions We reported a negative correlation between serum Sirt6 concentration and aging in human beings. Therefore, the Sirt6 serum level is a potential sex-specific aging marker.

scholarly journals Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age

2017 ◽  
Vol 123 (1) ◽  
pp. 106-115 ◽  
Author(s):  
William E. Hughes ◽  
Nicholas T. Kruse ◽  
Darren P. Casey
Keyword(s):  
Older Adults ◽  
Cold Pressor Test ◽  
Age Groups ◽  
Cold Pressor ◽  
Rapid Onset ◽  
Knee Extension ◽  
Lower Limbs ◽  
Age Related ◽  
Sympathetic Vasoconstriction ◽  
Rate Maximum

Contraction-induced rapid vasodilation is attenuated similarly in the upper and lower limbs of older adults. In the forearm, this attenuation is in part due to a greater sympathetic vasoconstriction. We examined whether the age-related reduction in contraction-induced vasodilation in the leg is also due to a sympathetic vasoconstrictive mechanism. Thirteen young (24 ± 1 yr) and twelve older adults (67 ± 1 yr) performed single-leg knee extension at 20 and 40% of work-rate maximum (WRmax) during control and cold-pressor test (CPT) conditions. Femoral artery diameter and blood velocity were measured using Doppler ultrasound. Vascular conductance (VC; ml·min−1·mmHg−1) was calculated using blood flow (ml/min) and mean arterial pressure (mmHg). Peak (ΔVC from baseline) and total VC were blunted in older adults during control conditions across exercise intensities ( P < 0.05). Peak and total VC were reduced during CPT in both age groups across exercise intensities ( P < 0.05). The relative change (i.e., %reduction; CPT vs. control) in peak (−25 ± 5 vs. −22 ± 4% at 20% WRmax; and −21 ± 6 vs. −27 ± 5% at 40% WRmax; P = 0.42–0.55) and total VC (−28 ± 5 vs. −36 ± 6% at 20% WRmax; and −22 ± 8 vs. −33 ± 5% at 40% WRmax; P = 0.23–0.34) were similar between young and older adults. When matched for absolute workload (~10 W), age differences persisted in peak VC ( P < 0.05) under both conditions, with similar relative changes in peak and total VC during CPT. Our data suggest that 1) sympathetic stimulation reduces contraction-induced rapid vasodilation in the leg of young and older adults similarly; and 2) enhanced sympathetic vasoconstriction does not fully explain age-related differences in contraction-induced vasodilation within the leg. NEW & NOTEWORTHY Aging is associated with attenuated contraction-induced rapid onset vasodilation (ROV). Within the forearm, this attenuation is partially due to enhanced sympathetic vasoconstriction. In the current study, we found that sympathetic vasoconstriction reduces contraction-induced ROV within the leg of both young and older adults, with the magnitude of change being similar between age groups. Our current results suggest that age-related attenuations in contraction-induced ROV within the leg are not fully explained by a sympathetic vasoconstrictor mechanism.

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