scholarly journals The Therapeutic Effect of Extracellular Superoxide Dismutase (EC-SOD) Mouse Embryonic Fibroblast (MEF) on Collagen-Induced Arthritis (CIA) Mice

2008 ◽  
Vol 17 (12) ◽  
pp. 1371-1380 ◽  
Author(s):  
Dong Hoon Yu ◽  
Myoung Ok Kim ◽  
Sung Hyun Kim ◽  
Mi Jung Shin ◽  
Bong Soo Kim ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Therapeutic Effect ◽  
Mouse Embryonic Fibroblast ◽  
Extracellular Superoxide Dismutase ◽  
Collagen Induced Arthritis ◽  
Embryonic Fibroblast

Extracellular Superoxide Dismutase Induces Mouse Embryonic Fibroblast Proliferative Burst, Growth Arrest, Immortalization, and Consequent In Vivo Tumorigenesis

2014 ◽  
Vol 21 (10) ◽  
pp. 1460-1474 ◽  
Author(s):  
Maria Domenica Castellone ◽  
Angela Langella ◽  
Silvia Cantara ◽  
Juha P. Laurila ◽  
Lilja E. Laatikainen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Growth Arrest ◽  
Mouse Embryonic Fibroblast ◽  
Extracellular Superoxide Dismutase ◽  
Embryonic Fibroblast

scholarly journals Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Tiina Kelkka ◽  
Juha Petteri Laurila ◽  
Outi Sareila ◽  
Peter Olofsson ◽  
Mikko Olavi Laukkanen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Oxidative Burst ◽  
Adenoviral Vector ◽  
Extracellular Superoxide Dismutase ◽  
Wild Type ◽  
Collagen Induced Arthritis ◽  
Regulatory Subunits ◽  
Superoxide Dismutase 3 ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues. In inflamed tissues, superoxide is produced by the phagocytic NOX2 complex, which consists of the catalytic subunit NOX2 and several regulatory subunits (e.g., NCF1). To analyze whether SOD3 can regulate inflammation in the absence of functional NOX2 complex, we injected an adenoviral vector overexpressing SOD3 directly into the arthritic paws ofNcf1*/*mice with collagen-induced arthritis. SOD3 reduced arthritis severity in both oxidative burst-deficientNcf1*/*mice and also in wild-type mice. The NOX2 complex independent anti-inflammatory effect of SOD3 was further characterized in peritonitis, and SOD3 was found to reduce macrophage infiltration independently of NOX2 complex functionality. We conclude that the SOD3-mediated anti-inflammatory effect on arthritis and peritonitis operates independently of NOX2 complex derived oxidative burst.

scholarly journals Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase

2004 ◽  
Vol 50 (11) ◽  
pp. 3702-3711 ◽  
Author(s):  
Aron D. Ross ◽  
Nirmal K. Banda ◽  
Michele Muggli ◽  
William P. Arend
Keyword(s):  
Superoxide Dismutase ◽  
Extracellular Superoxide Dismutase ◽  
Collagen Induced Arthritis

scholarly journals Extracellular Superoxide Dismutase Is a Major Antioxidant in Human Fibroblasts and Slows Telomere Shortening

2002 ◽  
Vol 278 (9) ◽  
pp. 6824-6830 ◽  
Author(s):  
Violeta Serra ◽  
Thomas von Zglinicki ◽  
Mario Lorenz ◽  
Gabriele Saretzki
Keyword(s):  
Superoxide Dismutase ◽  
Human Fibroblasts ◽  
Extracellular Superoxide Dismutase ◽  
Telomere Shortening

Nitric Oxide and Blood Pressure in Mice Lacking Extracellular-Superoxide Dismutase

2002 ◽  
Vol 36 (7) ◽  
pp. 755-758 ◽  
Author(s):  
Lena M. Jonsson ◽  
Daryl D. Rees ◽  
Thomas Edlund ◽  
Stefan L. Marklund
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Superoxide Dismutase ◽  
Extracellular Superoxide Dismutase
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