Continuous Renal Replacement Therapy: A Review

Kidney is an important organ to maintain hemodynamic stability inside the human body. In patient with acute kidney injury (AKI) there was a decreased kidney function that could interfere hemodynamic stability which can lead to multi organ failure even death. Around 5-10% patients with AKI required renal replacement therapy (RRT) to support their decreased renal function. Continuous renal replacement therapy (CRRT) is one of RRT modality that commonly used for patients with AKI who are hemodynamically unstable or in critically ill conditions.CRRT could divided into 4 mode, slow continuous ultrafiltration (SCUF), continuous veno-venous hemofiltration (CVVH), continuous veno-venous hemodialysis (CVVHD) and continuous veno-venous hemodialfiltration (CVVHDF). CRRT used based on renal and nonrenal indication. Several studies are still trying to prove nonrenal indication of RRT, to ascertain whether CRRT could be used as therapy effectively. Therefore the indication, the mechanism and the comparison of renal replacement therapy are very important to be understood.

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Continuous Renal Replacement Therapy: A Review

Journal of Anesthesiology and Clinical Research ◽

10.37275/jacr.v1i2.212 ◽

2020 ◽

Vol 1 (2) ◽

pp. 63-77

Author(s):

Muja Hidin ◽

Yasir Teuku ◽

Dzaky.A.N

Keyword(s):

Acute Kidney Injury ◽

Renal Function ◽

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Organ Failure ◽

Kidney Function ◽

Human Body ◽

Kidney Injury ◽

Hemodynamic Stability

ABSTRACT Kidney is an important organ to maintain hemodynamic stability inside the human body. In patient with acute kidney injury (AKI) there was a decreased kidney function that could interfere hemodynamic stability which can lead to multi organ failure even death. Around 5-10% patients with AKI required renal replacement therapy (RRT) to support their decreased renal function. Continuous renal replacement therapy (CRRT) is one of RRT modality that commonly used for patients with AKI who are hemodynamically unstable or in critically ill conditions. CRRT could divided into 4 mode, slow continuous ultrafiltration (SCUF), continuous veno-venous hemofiltration (CVVH), continuous veno-venous hemodialysis (CVVHD) and continuous veno-venous hemodialfiltration (CVVHDF). CRRT used based on renal and nonrenal indication. Several studies are still trying to prove nonrenal indication of RRT, to ascertain whether CRRT could be used as therapy effectively. Therefore the indication, the mechanism and the comparison of renal replacement therapy are very important to be understood.

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Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy

The Korean Journal of Internal Medicine ◽

10.3904/kjim.2014.290 ◽

2016 ◽

Vol 31 (5) ◽

pp. 930-937 ◽

Cited By ~ 3

Author(s):

Hee-Yeon Jung ◽

Jong-Hak Lee ◽

Young-Jae Park ◽

Sang-Un Kim ◽

Kyung-Hee Lee ◽

...

Keyword(s):

Acute Kidney Injury ◽

Renal Function ◽

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Kidney Injury

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CONTINUOUS RENAL REPLACEMENT THERAPY VS INTERMITTENT HEMODIALYSIS AND RECOVERY OF RENAL FUNCTION IN CRITICALLY ILL PATIENTS WITH ACUTE KIDNEY INJURY

CHEST Journal ◽

10.1016/j.chest.2020.08.658 ◽

2020 ◽

Vol 158 (4) ◽

pp. A701

Author(s):

Manuel Huerfano ◽

Roberto Buitrago ◽

Maria Jose Vargas ◽

Gabriel Ortiz Jaimes ◽

Maurcio Sanabria ◽

...

Keyword(s):

Acute Kidney Injury ◽

Renal Function ◽

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Critically Ill ◽

Critically Ill Patients ◽

Kidney Injury ◽

Intermittent Hemodialysis

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Recovery of renal function after acute kidney injury requiring continuous renal replacement therapy

Critical Care ◽

10.1186/cc13579 ◽

2014 ◽

Vol 18 (Suppl 1) ◽

pp. P389

Author(s):

HY Jung ◽

KH Kim ◽

SC Park ◽

JY Choi ◽

SH Park ◽

...

Keyword(s):

Acute Kidney Injury ◽

Renal Function ◽

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Kidney Injury

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Primary Injuries and Secondary Organ Failures in Trauma Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy

Scientifica ◽

10.1155/2014/235215 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6

Author(s):

Sigrid Beitland ◽

Ingrid Os ◽

Kjetil Sunde

Keyword(s):

Acute Kidney Injury ◽

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Multiple Organ Failure ◽

Replacement Therapy ◽

Organ Failure ◽

Kidney Injury ◽

Multiple Organ ◽

Trauma Patients ◽

Organ Failures

Background. Acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) is a severe complication in trauma patients. The aim of the study was to assess primary traumatic injuries and secondary organ failures in severe posttraumatic AKI.Methods. Retrospective review of adult trauma patients admitted to the trauma centre at Oslo University Hospital Ullevål. Injury severity score (ISS) was used to assess the severity of primary injuries, and sequential organ failure assessment (SOFA) score was utilized to measure secondary organ failures.Results. Forty-two (8%) of 506 trauma patients admitted to intensive care unit developed AKI treated with CRRT, whereof 40 (95%) suffered blunt trauma mechanisms. Patients had extensive primary organ injuries with median (interquartile range) ISS 36 (27–49). The majority of the patients had respiratory (93% intubated) and cardiovascular (67% with inotropic and/or vasoactive medication) failure within 24 hours after admission. AKI was often part of multiple organ failure, most frequently respiratory and cardiovascular failure, affecting 33 (75%) and 30 (71%) of the patients, respectively.Conclusion. Trauma patients with AKI undergoing CRRT often had severe primary injuries due to blunt trauma. Most of them suffered from secondary multiple organ failure concomitant to AKI.

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