Protective Effect of Corni fructus Ethanol Extracts Against Environmental Hormones in Human Prostate Cancer Cells

2009 ◽  
Vol 38 (6) ◽  
pp. 663-666 ◽  
Author(s):  
Seong-Hyuk Kwon ◽  
Soon-Jae Kwon ◽  
Jae-Yong Kim ◽  
Kyung-Wook Park ◽  
Ki-Hwan Shim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Protective Effect ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Ethanol Extracts ◽  
Corni Fructus

Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells

2010 ◽  
Vol 20 (22) ◽  
pp. 6435-6438 ◽  
Author(s):  
Seong-Hyuk Kwon ◽  
Hye-Young Park ◽  
Jae-Yong Kim ◽  
Il-Yun Jeong ◽  
Mi-Kyung Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Corni Fructus

The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways

2011 ◽  
Vol 1 (11) ◽  
pp. 457 ◽  
Author(s):  
Thomas Wang ◽  
Stephen M. Boue ◽  
Hari B. Krishnan
Keyword(s):  
Prostate Cancer ◽  
Protective Effect ◽  
Cancer Cells ◽  
Molecular Techniques ◽  
Molecular Signature ◽  
Human Prostate ◽  
Protective Effects ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Background Population

Background: Population studies suggested that consumption of a soy rich diet provides protective effects against several chronic diseases, including prostate cancer. However, the active components in soy as well as the mechanisms of action of soy’s protective effects remain unclear. It would be important to elucidate these questions to support the use of soy in the prevention of chronic disease.Methods: A cell culture model and molecular techniques were used as tools to identify a molecular signature induced by soy-derived phytochemicals.Results: Soy phytochemicals inhibit growth of androgen responsive prostate cancer cells. Global gene expression analysis using DNA microarray and real time PCR analysis identified multiple pathways affected by the soy-derived phytochemicals genistein, daidzein, equol, and glyceollins in the androgen responsive human prostate cancer cell LNCaP. These pathways included androgen receptor-dependent pathways, insulin-like growth factors pathways, and cell cycle-related pathways. Soy-derived phytochemicals modulated these pathways in a concentration-dependent fashion.Conclusion: Taking into consideration the physiological achievable concentration of diet-derived soy phytochemicals, we propose the concentration-dependent cancer protective effect is likely mediated through modulation of hormone/cytokine-dependent pathways.

Osteoblast-derived factors increased metastatic potential in human prostate cancer cells

2016 ◽  
Author(s):  
Terese Karlsson ◽  
Reshma Sundar ◽  
Anders Widmark ◽  
Marene Landstrom ◽  
Emma Persson
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Metastatic Potential ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Anticancer Activity of Methyl Gallate in RC-58T/h/SA#4 Primary Human Prostate Cancer Cells

2014 ◽  
Vol 43 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Soon Jae Kwon ◽  
Ju Hye Lee ◽  
Jae Yong Kim ◽  
Kwang Deog Moon ◽  
Sung Tae Yee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Methyl Gallate ◽  
Prostate Cancer Cells
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