THE RESULTS OF THE APPLICATION OF LYMPHOTROPIC THERAPY IN PATIENTS LUNG CANCER

Objectives. To evaluate the results of the application of the developed method of lymphotropic therapy in patients operated on for lung cancer. Methods. Examined 280 patients aged from 39 to 75 years, operated on for lung cancer during the period from 2010 to 2016, Completed: pneumonectomy or forehead - and bilobectomy, lymph node dissection. The patients were divided into three groups. In the first group (n=206) used only standard therapy. In the second group (n=44) in conjunction with standard therapy was performed with an interspinal lymphotropic injections of drugs at the level of Th2 - Th3, Th3 - Th4, Th4 - Th5. In the third group (n=30) in conjunction with standard therapy was performed lymphotropic introduction of medicines by the developed technique (patent RF №2561832). Results. Frequent complications in the first group and 20.4% in the second, 11.4% of patients were inflammatory. Bronchopleural fistula occurred in the first group, 17 % of patients in the second - 4.5%, in the third - from 3.3 percent. Indicators leukocyte index of intoxication on the 2nd day of 3.2±0.2 and on the 6th day 2,6±0,1 significantly smaller in patients in the third group (p<0,05) compared to first and second groups. Conclusion. The proposed method lymphotropic administration of drugs in patients with lung cancer provides the optimal route of administration of drugs to the pathological focus and reduces exudative inflammatory postoperative complications.

Download Full-text

Effectiveness and postoperative pain level of single-port versus two-port thoracoscopic lobectomy for lung cancer: a retrospective cohort study

General Thoracic and Cardiovascular Surgery ◽

10.1007/s11748-020-01479-z ◽

2020 ◽

Author(s):

Cheng-guang Hu ◽

Kang Zheng ◽

Guan-hua Liu ◽

Zhi-long Li ◽

Yan-li Zhao ◽

...

Keyword(s):

Lung Cancer ◽

Lymph Node ◽

Postoperative Pain ◽

Postoperative Complications ◽

Clinical Outcomes ◽

Lymph Node Dissection ◽

Single Port ◽

Operation Time ◽

Node Dissection ◽

Thoracoscopic Lobectomy

Abstract Objectives Single-port thoracoscopic lobectomy is a new therapeutic technique for patients with lung cancer; however, insufficient data are available regarding its clinical outcomes. We therefore compared the clinical outcomes of single-port and two-port thoracoscopic lobectomies for lung cancer. Methods We retrospectively analyzed and compared the data of 204 and 368 patients with lung cancer who underwent single-port or two-port thoracoscopic lobectomy, respectively, between October 2014 and October 2017 at our institution. Patients in both groups underwent 1:1 propensity score matching, and 400 patients (200 patients in each group) were included. Perioperative clinical indicators were analyzed, including operation time, lymph node dissection stations and numbers, incidence of postoperative complications, and pain scores at 24 h, 72 h, and 1 week after surgery. Results No perioperative deaths occurred in either group. The operation time, intraoperative blood loss, chest drainage duration, duration of postoperative hospital stay, lymph node dissection station and number, rate of conversion to open surgery, number of ruptured intraoperative pulmonary vessel, and incidence of postoperative complications were not significantly different between the groups (all P > 0.05). However, analysis of the 24-h (P = 0.005), 72-h (P = 0.011), and 1-week (P = 0.034) visual analog scale score after surgery revealed that the postoperative pain levels were significantly lower in the single-port than in the two-port group. Conclusions Single-port and two-port thoracoscopic lobectomies had similar perioperative outcomes, although the postoperative pain was lower after single-port than two-port thoracoscopic lobectomy. Hence, we concluded that single-port thoracoscopic lobectomy is an effective, minimally invasive, and promising surgical procedure.

Download Full-text