scholarly journals Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease

2014 ◽  
Vol 20 (40) ◽  
pp. 14805 ◽  
Author(s):  
Zi-Kai Wang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

Su1740 Dynamic Changes in the Intestinal Microbiota Following Fecal Microbiota Transplantation for Refractory Inflammatory Bowel Disease in Children

2016 ◽  
Vol 150 (4) ◽  
pp. S541
Author(s):  
Brian R. Bush ◽  
Matthew B. Rogers ◽  
Brian Firek ◽  
Adam Kufen ◽  
Zachary Jackson ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Dynamic Changes ◽  
Inflammatory Bowel

Fecal Microbiota Transplantation in Inflammatory Bowel Disease

2017 ◽  
Vol 35 (1-2) ◽  
pp. 123-126 ◽  
Author(s):  
Walter Reinisch
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Intestinal Barrier ◽  
Disease Status ◽  
Fecal Microbiota ◽  
Intestinal Immune System ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

The etiology of inflammatory bowel disease (IBD) is unknown, but it is thought to arise from an aberrant immune response to a change in colonic environment in a genetically susceptible individual. The intestinal microbiota are located at the complex interface of the epithelial barrier and are sensitive to changes in environmental factors, such as diets, drugs or smoking and signals derived from the intestinal immune system and the gut-brain axis. In patients with IBD, an imbalance in the structural and/or functional configuration of the intestinal microbiota leading to the disruption of the host-microorganism homeostasis (dysbiosis) has been reproducibly reported. As animal models of IBD require gut bacteria to induce inflammation, it is hypothesized that the dysbiosis observed in patients is not only a surrogate of changes at the intestinal barrier but also a potential cause or at least enhancer of the mucosal inflammatory process. That burgeoning notion has stimulated thoughts to modify the intestinal microbiota and rekindled interest in previous work on the efficacy of antibiotics in patients with IBD. The feasibility and tremendous success of fecal microbiota transplantation (FMT) to treat antibiotic resistant Clostridium difficile has finally paved the way to embark into the unchartered territory of IBD using FMT. Different routes and number of administrations, choices of donors, disease status and permitted therapies might have contributed to mixed results, particularly from the so far published randomized controlled trials. However, microbiome analysis suggests that a durable transplantation of donor bacteria to the host appears feasible and might be associated with a higher likelihood of response. On the other hand, this raises the concern of transplanting not only anti-inflammatory active bacteria and their products, but also not-yet-known dispositions for other diseases including cancer. Attempts are being made to better characterize those components of the microbiome of healthy individuals, which might mediate anti-inflammatory functions and assemble ‘synthetic stools' for more standardized treatment approaches.

scholarly journals Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Gut Microbes ◽  
2017 ◽  
Vol 8 (3) ◽  
pp. 238-252 ◽  
Author(s):  
Alexa R. Weingarden ◽  
Byron P. Vaughn
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

P013 Characteristics of Fecal Microbiota Transplantation Use in Inflammatory Bowel Disease cohort

2019 ◽  
Vol 114 (1) ◽  
pp. S4-S4
Author(s):  
Christina Bauer ◽  
Millie Long ◽  
Xian Zhang ◽  
Robert Sandler
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

scholarly journals Fecal microbiota transplantation as a new treatment for canine inflammatory bowel disease

2020 ◽  
Author(s):  
Ayaka NIINA ◽  
Ryoko KIBE ◽  
Ryohei SUZUKI ◽  
Yunosuke YUCHI ◽  
Takahiro TESHIMA ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel ◽  
New Treatment

scholarly journals Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease

mBio ◽  
2021 ◽  
Author(s):  
Nathaniel D. Chu ◽  
Jessica W. Crothers ◽  
Le T. T. Nguyen ◽  
Sean M. Kearney ◽  
Mark B. Smith ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune System ◽  
Bowel Disease ◽  
Healthy Donor ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Complex Mixtures ◽  
Sick Patient ◽  
Inflammatory Bowel ◽  
Living Organisms

Fecal microbiota transplantation (FMT)—transferring fecal microbes from a healthy donor to a sick patient—has shown promise for gut diseases such as inflammatory bowel disease. However, unlike pharmaceuticals, fecal transplants are complex mixtures of living organisms, which must then interact with the microbes and immune system of the recipient.

Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Primer for Internists

2018 ◽  
Vol 131 (9) ◽  
pp. 1017-1024 ◽  
Author(s):  
Gaurav Syal ◽  
Amir Kashani ◽  
David Q. Shih
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

Outcomes of Fecal Microbiota Transplantation for C. difficile Infection in Inflammatory Bowel Disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Raseen Tariq ◽  
Tausif Syed ◽  
Devvrat Yadav ◽  
Larry J. Prokop ◽  
Siddharth Singh ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

scholarly journals 7 – The Icon Study: Inflammatory Bowel Disease and Recurrent Clostridium Difficile Infection: Outcomes After Fecal Microbiota Transplantation

2019 ◽  
Vol 156 (6) ◽  
pp. S-2-S-3 ◽  
Author(s):  
Jessica R. Allegretti ◽  
Jonathan Hurtado ◽  
Madeline Carrellas ◽  
Jenna Marcus ◽  
Emmalee Phelps ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Recurrent Clostridium Difficile Infection ◽  
Inflammatory Bowel
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