Role of intestinal microbiota and fecal microbiota transplantation in inflammatory bowel disease

2016 ◽  
Vol 24 (9) ◽  
pp. 1386
Author(s):  
Li-Jun Yan
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

Role of Fecal Microbiota Transplantation in Treating Inflammatory Bowel Disease and Clostridium difficile Infection: Narrative Review

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1526
Author(s):  
Zaheer A. Qureshi ◽  
Sherry Reyes ◽  
Sharmi Biswas ◽  
Sri Lekha Bodepudi ◽  
Stacey E. Thomas ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Narrative Review ◽  
Inflammatory Bowel

The Role of Fecal Microbiota Transplantation in Ulcerative Colitis and Crohn's Disease: Results from a Parallel Inflammatory Bowel Disease Cohort Study

2017 ◽  
Vol 152 (5) ◽  
pp. S1008 ◽  
Author(s):  
Najwa El-Nachef ◽  
Yvette M. Piceno ◽  
Zain Kassam ◽  
Adriel-John Ablaza ◽  
Martin Zydek ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

Su1740 Dynamic Changes in the Intestinal Microbiota Following Fecal Microbiota Transplantation for Refractory Inflammatory Bowel Disease in Children

2016 ◽  
Vol 150 (4) ◽  
pp. S541
Author(s):  
Brian R. Bush ◽  
Matthew B. Rogers ◽  
Brian Firek ◽  
Adam Kufen ◽  
Zachary Jackson ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Dynamic Changes ◽  
Inflammatory Bowel

Fecal Microbiota Transplantation in Inflammatory Bowel Disease

2017 ◽  
Vol 35 (1-2) ◽  
pp. 123-126 ◽  
Author(s):  
Walter Reinisch
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Intestinal Barrier ◽  
Disease Status ◽  
Fecal Microbiota ◽  
Intestinal Immune System ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

The etiology of inflammatory bowel disease (IBD) is unknown, but it is thought to arise from an aberrant immune response to a change in colonic environment in a genetically susceptible individual. The intestinal microbiota are located at the complex interface of the epithelial barrier and are sensitive to changes in environmental factors, such as diets, drugs or smoking and signals derived from the intestinal immune system and the gut-brain axis. In patients with IBD, an imbalance in the structural and/or functional configuration of the intestinal microbiota leading to the disruption of the host-microorganism homeostasis (dysbiosis) has been reproducibly reported. As animal models of IBD require gut bacteria to induce inflammation, it is hypothesized that the dysbiosis observed in patients is not only a surrogate of changes at the intestinal barrier but also a potential cause or at least enhancer of the mucosal inflammatory process. That burgeoning notion has stimulated thoughts to modify the intestinal microbiota and rekindled interest in previous work on the efficacy of antibiotics in patients with IBD. The feasibility and tremendous success of fecal microbiota transplantation (FMT) to treat antibiotic resistant Clostridium difficile has finally paved the way to embark into the unchartered territory of IBD using FMT. Different routes and number of administrations, choices of donors, disease status and permitted therapies might have contributed to mixed results, particularly from the so far published randomized controlled trials. However, microbiome analysis suggests that a durable transplantation of donor bacteria to the host appears feasible and might be associated with a higher likelihood of response. On the other hand, this raises the concern of transplanting not only anti-inflammatory active bacteria and their products, but also not-yet-known dispositions for other diseases including cancer. Attempts are being made to better characterize those components of the microbiome of healthy individuals, which might mediate anti-inflammatory functions and assemble ‘synthetic stools' for more standardized treatment approaches.

scholarly journals Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Gut Microbes ◽  
2017 ◽  
Vol 8 (3) ◽  
pp. 238-252 ◽  
Author(s):  
Alexa R. Weingarden ◽  
Byron P. Vaughn
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Bowel

scholarly journals Insights into the role of fecal microbiota transplantation for the treatment of inflammatory bowel disease

2019 ◽  
Vol 12 ◽  
pp. 175628481983689 ◽  
Author(s):  
Alexander N. Levy ◽  
Jessica R. Allegretti
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Novel Therapy ◽  
Complementary Role ◽  
Gut Homeostasis ◽  
Inflammatory Bowel ◽  
Study Designs

Fecal microbiota transplantation (FMT) has changed the treatment landscape of Clostridium difficile infection (CDI). Emerging evidence has shown that FMT can also be an effective and safe treatment strategy in CDI with underlying inflammatory bowel disease (IBD). Recently, randomized controlled trials of FMT in ulcerative colitis support its expanding role in restoring gut homeostasis in this disease. However, heterogeneous study designs leave several questions yet to be answered, including how to best position this novel therapy in the treatment approach of Crohn’s disease and pouchitis. Additional studies are needed to validate whether FMT can assume a complementary role in the standard treatment of IBD.

scholarly journals The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease

2021 ◽  
Vol 10 (18) ◽  
pp. 4055
Author(s):  
Magdalena Stojek ◽  
Anna Jabłońska ◽  
Krystian Adrych
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Response ◽  
Bowel Disease ◽  
Fecal Microbiota Transplantation ◽  
Management Strategies ◽  
Fecal Microbiota ◽  
Environmental Trigger ◽  
Inflammatory Bowel ◽  
Microbial Environment

The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice.

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