Occupational Exposure to Petroleum Workers by Assessing Urinary Methyl Hippuric Acid and Micronuclei in Oral Mucosa Cell

2019 ◽  
Vol 10 (12) ◽  
pp. 272
Author(s):  
Vidya Gowdappa Doddawad ◽  
Mohamad Ayas ◽  
B. M. Gurupadayya
Keyword(s):  
Occupational Exposure ◽  
Oral Mucosa ◽  
Hippuric Acid ◽  
Mucosa Cell

scholarly journals Analysis of lymphocyte and oral mucosa cell micronuclei in Cuban paint industry workers

Hereditas ◽  
2008 ◽  
Vol 113 (1) ◽  
pp. 77-80 ◽  
Author(s):  
SILVIA DIAZ ◽  
GLADIS FONSECA ◽  
IVONNE FERNANDEZ
Keyword(s):  
Oral Mucosa ◽  
Paint Industry ◽  
Mucosa Cell

Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes

2010 ◽  
Vol 30 (4) ◽  
pp. 338-342 ◽  
Author(s):  
Yong-Dae Kim ◽  
Sang-Yong Eom ◽  
Yan Wei Zhang ◽  
Hyeongsu Kim ◽  
Jung-Duk Park ◽  
...  
Keyword(s):  
Dna Damage ◽  
Occupational Exposure ◽  
Genetic Polymorphisms ◽  
Hippuric Acid ◽  
Oxidative Dna Damage ◽  
Statistical Significance ◽  
Biological Marker ◽  
Metabolizing Enzymes ◽  
Toluene Exposure ◽  
The Relationship

Urinary hippuric acid (HA) has been widely used as a biological marker of occupational exposure to toluene, although it is no longer valid for low levels of toluene exposure. Toluene exposure is known to induce oxidative DNA damage and the metabolism is affected by genetic polymorphisms of some metabolizing enzymes. Therefore, genetic polymorphisms of these metabolizing enzymes must be considered in the evaluation of oxidative stress caused by toluene exposure. We evaluated the relationship between urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and urinary HA in individuals without occupational exposure to toluene and characterized the possible roles of GSTM1, GSTT1, and aldehyde dehydrogenase 2 (ALDH2) genotypes in the relationships between these markers. In this study, we enrolled 92 healthy Koreans. Urinary HA and 8-OHdG levels were measured and the correlations between them were statistically tested according to the GSTM1, GSTT1, and ALDH2 genotypes. HA did not significantly correlate with urinary 8-OHdG in overall subjects. However, the correlation between them showed a statistical significance in individuals with GSTM1-null, GSTT1-null, and ALDH2 *2/*2 genotypes (r = 0.766, p < 0.01). This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.

scholarly journals The use of three-dimensional oral mucosa cell cultures to assess the toxicity of soldered and welded wires

2007 ◽  
Vol 29 (1) ◽  
pp. 60-66 ◽  
Author(s):  
B. Vande Vannet ◽  
J.-L. Hanssens ◽  
H. Wehrbein
Keyword(s):  
Oral Mucosa ◽  
Cell Cultures ◽  
Three Dimensional ◽  
Mucosa Cell

Hippuric acid and ortho-cresol as biological indicators of occupational exposure to toluene

1987 ◽  
Vol 11 (5) ◽  
pp. 529-537 ◽  
Author(s):  
E. de Rosa ◽  
G. B. Bartolucci ◽  
M. Sigon ◽  
R. Callegaro ◽  
L. Perbellini ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Hippuric Acid ◽  
Biological Indicators ◽  
Ortho Cresol

scholarly journals Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures.

2004 ◽  
Vol 51 (3) ◽  
pp. 831-837 ◽  
Author(s):  
Anna Zalewska ◽  
Małgorzata M Brzóska ◽  
Justyna Marciniak ◽  
Katarzyna Karaszewska ◽  
Krzysztof Zwierz ◽  
...  
Keyword(s):  
Drinking Water ◽  
Occupational Exposure ◽  
Oral Mucosa ◽  
Rat Model ◽  
Occupational Exposures ◽  
Submandibular Glands ◽  
Dose Dependent ◽  
Beta Galactosidase

Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of beta-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, beta-N-acetylhexosaminidase showed the highest activity. The activities of alpha-mannosidase and beta-galactosidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.

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