Flow carbonylation of sterically hindered ortho-substituted iodoarenes
2016 ◽
Vol 12
◽
pp. 1503-1511
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Keyword(s):
The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
2010 ◽
Vol 91
(1)
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pp. 17-21
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2017 ◽
Vol 21
(7)
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pp. 947-955
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Keyword(s):
2008 ◽
Vol 45
(5)
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pp. 1397-1399
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2019 ◽
Vol 58
(15)
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pp. 5085-5089
1991 ◽
Vol 79
(1-3)
◽
pp. 129-140
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