Synthesis and late stage modifications of Cyl-derivatives
Keyword(s):
A peptide Claisen rearrangement is used as key step to generate a tetrapeptide with a C-terminal double unsaturated side chain. Activation and cyclization give direct access to cyclopeptides related to naturally occurring histone deacetylases (HDAC) inhibitors Cyl-1 and Cyl-2. Late stage modifications on the unsaturated amino acid side chain allow the introduction of functionalities which might coordinate to metal ions in the active center of metalloproteins, such as histone deacetylases.
2006 ◽
Vol 27
(13)
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pp. 1534-1547
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Keyword(s):
Solvation free energies of amino acid side chain analogs for common molecular mechanics water models
2005 ◽
Vol 122
(13)
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pp. 134508
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Keyword(s):
2007 ◽
Vol 14
(4)
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pp. 379-386
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1985 ◽
Vol 47
(1)
◽
pp. 61-70
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1990 ◽
Vol 86
(18)
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pp. 3117-3123
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Keyword(s):