Significance The Biological Activity to Pyrimidine Analogues

Yossra A. March; Wijdan H. Al-Tamimi; Ali Abdulrazzaq Abdulwahid

doi:10.37623/sjmr.2020.41305

Significance The Biological Activity to Pyrimidine Analogues

Scientific Journal of Medical Research ◽

10.37623/sjmr.2020.41305 ◽

2020 ◽

Vol 04 (13) ◽

pp. 23-30

Author(s):

Yossra A. March ◽

Wijdan H. Al-Tamimi ◽

Ali Abdulrazzaq Abdulwahid

Keyword(s):

Biological Activity ◽

Pyrimidine Analogues

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Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2006.07.004 ◽

2006 ◽

Vol 41 (12) ◽

pp. 1405-1411 ◽

Cited By ~ 34

Author(s):

Vladimír Kryštof ◽

Daniela Moravcová ◽

Martina Paprskářová ◽

Pascale Barbier ◽

Vincent Peyrot ◽

...

Keyword(s):

Biological Activity ◽

Pyrimidine Analogues

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Synthesis and Biological Activity of 8-Azapurine and Pyrazolo[4,3-d]pyrimidine Analogues of Myoseverin.

ChemInform ◽

10.1002/chin.200717217 ◽

2007 ◽

Vol 38 (17) ◽

Author(s):

Vladimir Krystof ◽

Daniela Moravcova ◽

Martina Paprskarova ◽

Pascale Barbier ◽

Vincent Peyrot ◽

...

Keyword(s):

Biological Activity ◽

Pyrimidine Analogues

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Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity

Journal of Medicinal Chemistry ◽

10.1021/jm101254z ◽

2011 ◽

Vol 54 (2) ◽

pp. 655-668 ◽

Cited By ~ 31

Author(s):

Mi-Yeon Jang ◽

Yuan Lin ◽

Steven De Jonghe ◽

Ling-Jie Gao ◽

Bart Vanderhoydonck ◽

...

Keyword(s):

Biological Activity ◽

Immunosuppressive Agents ◽

Pyrimidine Analogues

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Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072332 ◽

1973 ◽

Vol 31 ◽

pp. 378-379

Author(s):

G. Kasnic ◽

S. E. Stewart ◽

C. Urbanski

Keyword(s):

Breast Cancer ◽

Biological Activity ◽

Human Breast Cancer ◽

Osteogenic Sarcoma ◽

Human Tumor ◽

Structural Similarity ◽

Cell Tumor ◽

Human Breast ◽

Human Tumor Cell ◽

Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100090270 ◽

1976 ◽

Vol 34 ◽

pp. 58-59

Author(s):

John L. Beggs ◽

John D. Waggener ◽

Wanda Miller

Keyword(s):

Spinal Cord ◽

Biological Activity ◽

Horseradish Peroxidase ◽

Transport Mechanism ◽

Vasogenic Edema ◽

Vesicular Transport ◽

Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

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