scholarly journals Non-invasive Measurement of Myocardial Blood Flow with Positron Emission Tomography and 15O Steady-state Method Using a Continuous Infusion of H215O.

RADIOISOTOPES ◽  
1993 ◽  
Vol 42 (11) ◽  
pp. 629-633
Author(s):  
Yasuo KUWABARA ◽  
Yuichi ICHIYA ◽  
Makoto OTSUKA ◽  
Masayuki SASAKI ◽  
Yuko AKASHI ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Steady State ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Non Invasive ◽  
Steady State Method ◽  
Positron Emission ◽  
State Method ◽  
Invasive Measurement

scholarly journals Linearization Correction of 99mTc-Labeled Hexamethyl-Propylene Amine Oxime (HM-PAO) Image in Terms of Regional CBF Distribution: Comparison to C15O2 Inhalation Steady-State Method Measured by Positron Emission Tomography

1988 ◽  
Vol 8 (1_suppl) ◽  
pp. S52-S60 ◽  
Author(s):  
Atsushi Inugami ◽  
Iwao Kanno ◽  
Kazuo Uemura ◽  
Fumio Shishido ◽  
Matsutaro Murakami ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Emission Tomography ◽  
Emission Computed Tomography ◽  
Whole Brain ◽  
Steady State Method ◽  
Positron Emission ◽  
State Method

The radioisotope distribution following intravenous injection of 99mTc-labeled hexamethylpropyleneamine oxime (HM-PAO) in the brain was measured by single photon emission computed tomography (SPECT) and corrected for the nonlinearity caused by differences in net extraction. The “linearization” correction was based on a three compartment model, and it required a region of reference to normalize the SPECT image in terms of regional cerebral blood flow distribution. Two different regions of reference, the cerebellum and the whole brain, were tested. The uncorrected and corrected HM-PAO images were compared with cerebral blood flow (CBF) image measured by the C15O2 inhalation steady state method and positron emission tomography (PET). The relationship between uncorrected HM-PAO and PET–CBF showed a correlation coefficient of 0.85 but tended to saturate at high CBF values, whereas it was improved to 0.93 after the “linearization” correction. The whole-brain normalization worked just as well as normalization using the cerebellum. This study constitutes a validation of the “linearization” correction and it suggests that after linearization the HM-PAO image may be scaled to absolute CBF by employing a global hemispheric CBF value as measured by the nontomographic 133Xe clearance method.

scholarly journals Quantitative Comparison of the Bolus and Steady-State Methods for Measurement of Cerebral Perfusion and Oxygen Metabolism: Positron Emission Tomography Study Using 15O-Gas and Water

2001 ◽  
Vol 21 (7) ◽  
pp. 793-803 ◽  
Author(s):  
Hidehiko Okazawa ◽  
Hiroshi Yamauchi ◽  
Kanji Sugimoto ◽  
Masaaki Takahashi ◽  
Hiroshi Toyoda ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Steady State ◽  
Blood Volume ◽  
Cerebral Perfusion ◽  
Oxygen Metabolism ◽  
Emission Tomography ◽  
Parametric Images ◽  
Steady State Method ◽  
Positron Emission ◽  
State Method

To evaluate a new simplified bolus method for measurement of cerebral perfusion and metabolism, the parametric images with that method were compared with those obtained from the conventional steady-state method with 15O-gas. The new method also provided images of arterial blood volume (V0), which is a different parameter from cerebral blood volume (CBV) obtained using a C15O technique. Seven healthy volunteers and 10 patients with occlusive cerebrovascular diseases underwent positron emission tomography (PET) scans with both methods. Three-weighted integration was applied to calculate regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of oxygen (rCMRO2) in the bolus method. Global and regional CBF and CMRO2 in volunteers were compared between the two methods and used as control data. Regional values in patients also were evaluated to observe differences between the bilateral hemispheres. Both rCBF and rCMRO2 were linearly well correlated between the two methods, although global difference in CMRO2 was significant. The difference in each parametric image except for V0 was significant between the bilateral hemispheres in patients. The bolus method can simplify oxygen metabolism studies and yield parametric images comparable with those with the steady-state method, and can allow for evaluation of V0 simultaneously. Increase in CBV without a change in V0 suggested the increase might mainly be caused by venous dilatation in the ischemic regions.

scholarly journals Cerebral Oxygen Metabolism of Rats using Injectable 15O-Oxygen with a Steady-State Method

2011 ◽  
Vol 32 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Masato Kobayashi ◽  
Tetsuya Mori ◽  
Yasushi Kiyono ◽  
Vijay Narayan Tiwari ◽  
Rikiya Maruyama ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Steady State ◽  
Emission Tomography ◽  
Tracer Injection ◽  
Simple Method ◽  
Whole Brain ◽  
Steady State Method ◽  
Positron Emission ◽  
State Method ◽  
Cerebral Arterial Occlusion

To develop a less-stressful and simple method for measurement of the cerebral metabolic rate of oxygen ( CMRO2) in small animals, the steady-state method was applied to injectable 15O2-PET (15O2-positron emission tomography) using hemoglobin-containing vesicles (15O2-HbV). Ten normal rats and 10 with middle cerebral arterial occlusion (MCAO) were studied using a small animal PET scanner. A series of 15O-PET scans with C15O-labeled HbV, H215O, and 15O2-HbV were performed with 10 to 15 minutes intervals to measure cerebral blood volume (CBV), cerebral blood flow (CBF), and CMRO2. Positron emission tomography scans were started with a tracer injection using a multiprogramming syringe pump, which provides a slowly increasing injection volume to achieve steady-state radioactivity for H215O and 15O2-HbV scans. The radioactivity concentration of 15O rapidly achieved equilibrium in the blood and whole brain at about 2 minutes after H215O and 15O2-HbV administration, which was stable during the scans. The whole brain mean values of CBF, CBV, and CMRO2 were 54.3 ± 2.0 mL per 100 g per minute, 4.9 ± 0.4 mL/100 g, and 2.8 ±0.2 μmoL per g per minute (6.2 ± 0.4 mL per 100 g per minute) in the normal rats, respectively. In the MCAO model rats, all hemodynamic parameters of the infarction area on the occlusion side significantly decreased. The steady-state method with 15O-labeled HbV is simple and useful to analyze hemodynamic changes in studies with model animals.

scholarly journals Measurement of Cerebral Blood Flow Using Bolus Inhalation of C15O2 and Positron Emission Tomography: Description of the Method and its Comparison with the C15O2 Continuous Inhalation Method

1984 ◽  
Vol 4 (2) ◽  
pp. 224-234 ◽  
Author(s):  
Iwao Kanno ◽  
Adriaan A. Lammertsma ◽  
Jon D. Heather ◽  
Jeremy M. Gibbs ◽  
Christopher G. Rhodes ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Emission Tomography ◽  
Single Breath ◽  
Steady State Method ◽  
Positron Emission ◽  
State Technique ◽  
The Difference

This article describes a rapid method for the regional measurement of cerebral blood flow using a single breath of C15O2 and positron emission tomography. The technique is based on the bolus distribution principle and utilises a reference table for the calculation of flow. Seven subjects were studied using both this method and the C15O2 continuous inhalation steady-state technique. The single-breath method gave flow values 20% higher than those obtained using the steady-state method. A simulation study was performed in an attempt to define the reasons for the difference between the two techniques. Estimations were made of identified sources of error in the measurement of regional cerebral blood flow using the single-breath technique and compared with results from a similar study previously described for the steady-state technique. However, further comparative studies will be necessary to satisfactorily explain the difference between both techniques.

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