Traumatic and Iatrogenic Choroidal Neovascularization

2017 ◽  
pp. 330-335
Keyword(s):  
Bone Marrow ◽  
Optical Coherence Tomography ◽  
Gene Transfer ◽  
Laser Photocoagulation ◽  
Optical Coherence Tomography Angiography ◽  
Spot Size ◽  
High Energy ◽  
Macular Surgery ◽  
Small Spot ◽  
Fibrovascular Proliferation

Iatrogenic CNVs have been reported primarily due to laser photocoagulation and, secondly, due to complications of macular surgery. It has been reported that chorio-ovitreal and subretinal fibrovascular proliferation following heavy focal photocoagulation are complications of high energy with small spot size application. Apart from the CNVs that occur as iatrogenic laser complications, CNVs formed by laser pointers can also be seen. During macular surgery, CNV may also develop due to RPE and BM trauma and deterioration of their integrity. While fundus exam, FFA, OCT, and Optical Coherence Tomography Angiography (OCTA) are valuable for diagnosis, in recent years, experimental animal laser-induced CNV studies, especially bone marrow-derived monocyte-macrophages playing an important role, and underlying related molecular mechanism studies have been intensified. One of the therapeutic examples of treatment is a gene transfer shown in experimental rat studies. Nevertheless, there is a need for further studies on diagnosis and treatment.

scholarly journals Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity

2022 ◽  
Vol 15 (1) ◽  
pp. 106-112
Author(s):  
Xun Deng ◽  
◽  
Xue-Mei Zhu ◽  
Dan-Dan Linghu ◽  
Hua Xu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Retinopathy Of Prematurity ◽  
Laser Photocoagulation ◽  
Optical Coherence Tomography Angiography ◽  
Full Thickness ◽  
Anti Vegf ◽  
Laser Group ◽  
Type 1 Rop

AIM: To evaluate foveal vessel density (VD) and foveal thickness using optical coherence tomography angiography (OCTA) in retinopathy of prematurity (ROP) children treated with laser photocoagulation or anti-vascular endothelial growth factor (VEGF) injection. Additionally, we assessed the relationship between foveal microvascular anomalies and different therapies in ROP children. METHODS: This was a single-center, retrospective study of patients with a diagnosis of type 1 ROP. Twenty-three eyes (14 patients) treated with anti-VEGF injection and twenty-nine eyes (17 patients) treated with laser coagulation were included in this study. The foveal VD, inner thickness and full thickness were measured at the central 0°, 2° to 8°, and 8° of the retina (centered on the fovea) using OCTA and cross-sectional OCT, respectively. RESULTS: Foveal VD, inner thickness and full thickness were significantly smaller within the central 8° of the retina in ROP children treated with anti-VEGF injection than in those treated with laser photocoagulation (P=0.013, 0.009, 0.036, respectively). The full thickness was also smaller in the anti-VEGF group than in the laser group at the central 0° of the retina (P=0.010). The grade of foveal hypoplasia is lower in the anti-VEGF group than in the laser group (P=0.045). Multivariable analysis did not find any risk factors associated with visual acuity in our study. CONCLUSION: In children with type 1 ROP, the better structural development of fovea in those who were treated with anti-VEGF injection compared with laser photocoagulation are identified. However, visual acuity outcomes are similar 70mo after the treatments.

Ultra-spatially resolved synchrotron powered FT-IR microspectroscopy of individual cells of biological material

1995 ◽  
Vol 53 ◽  
pp. 884-885
Author(s):  
David L. Wetzel ◽  
John A. Reffner ◽  
Gwyn P. Williams
Keyword(s):  
Thermal Noise ◽  
Spot Size ◽  
Acquisition Time ◽  
Thermal Source ◽  
Signal To Noise ◽  
Spatially Resolved ◽  
Good Spatial Resolution ◽  
Small Spot ◽  
Ft Ir ◽  
Ir Microspectroscopy

Synchrotron radiation is 100 to 1000 times brighter than a thermal source such as a globar. It is not accompanied with thermal noise and it is highly directional and nondivergent. For these reasons, it is well suited for ultra-spatially resolved FT-IR microspectroscopy. In efforts to attain good spatial resolution in FT-IR microspectroscopy with a thermal source, a considerable fraction of the infrared beam focused onto the specimen is lost when projected remote apertures are used to achieve a small spot size. This is the case because of divergence in the beam from that source. Also the brightness is limited and it is necessary to compromise on the signal-to-noise or to expect a long acquisition time from coadding many scans. A synchrotron powered FT-IR Microspectrometer does not suffer from this effect. Since most of the unaperatured beam’s energy makes it through even a 12 × 12 μm aperture, that is a starting place for aperture dimension reduction.

scholarly journals Optical coherence tomography angiography monitors human cutaneous wound healing over time

2018 ◽  
Vol 8 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Anthony J. Deegan ◽  
Wendy Wang ◽  
Shaojie Men ◽  
Yuandong Li ◽  
Shaozhen Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Over Time
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