28 women with leukoplakia of the bladder, clinically manifested by dysuria and pain in the bladder were observed. All patients have a history of chronic urinary tract infection. At the time of inclusion in the study there were no signs of exacerbation of cystitis. All patients underwent laser ablation of the altered bladder mucosa. Control examinations were performed 1, 3, and 6 months after surgery. Positive dynamics of clinical indicators was noted after surgery in all patients. Tolerance to laser ablation was satisfactory, there were no postoperative complications. A complete recovery of urothelium in the operation area was achieved after 6 months according to control cystoscopy. The results of the study showed high efficiency and safety of laser ablation of the altered bladder mucosa in patients with leukoplakia.