scholarly journals MATERNAL INFECTION WITH PARVOVIRUS B19 LEADING TO FETAL HYDROPS AND INTRAUTERINE DEATH – CASE PRESENTATION

2016 ◽  
Vol 19 (3) ◽  
pp. 73-77
Author(s):  
Mărginean Claudiu ◽  
◽  
Pușcașiu Lucian ◽  
Molnar Varlam Claudiu ◽  
Rugină Cosmin ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
First Trimester ◽  
Intrauterine Death ◽  
Severe Anemia ◽  
Fetal Hydrops ◽  
Fetal Ultrasound ◽  
Recent Infection ◽  
Trimester Abortion ◽  
To Come ◽  
Human Line

Parvovirus B19 belongs to the Parvoviridae family, Erythrovirus type, and it presents cytotoxicity on the erythroblast human line leading to severe anemia. We present the case of a 35-year-old woman, at the 3rd pregnancy, with a first trimester abortion in her history and a physiological birth, who presented to the specialty check-up at 20 gestational weeks, associating the signs of a respiratory infection, without any other pathologies until this gestational age. The laboratory tests and the fetal ultrasound did not point out any pathological elements, therefore the patient was sent home with the recommendation to come back after 2 weeks for reevaluation, when the fetal ultrasound revealed fetal hydrops and severe anemia, and after 24 hours fetal asystole. Maternal serology pointed out recent infection with Parvovirus B19. The particularity of this case consists in the appearance of relative rare fetal infection in the second trimester of pregnancy in the case of a physiological, monitored pregnancy, with unfavorable prognosis and fulminant death towards intrauterine death.

scholarly journals Maternal Parvovirus B19 Infection Causing First-Trimester Increased Nuchal Translucency and Fetal Hydrops

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Olivia Grubman ◽  
Farrah Naz Hussain ◽  
Zoe Nelson ◽  
Lois Brustman
Keyword(s):  
Parvovirus B19 ◽  
Peak Systolic Velocity ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Normal Male ◽  
Fetal Hydrops ◽  
Erythroid Progenitor ◽  
Parvovirus B19 Infection ◽  
Male Karyotype ◽  
Increased Nuchal Translucency

This is a case report of a 31-year-old primigravida who was diagnosed with an asymptomatic acute parvovirus B19 infection in the second trimester of pregnancy and its suspected association with an increased nuchal translucency (NT) measurement. Parvovirus B19 is a single-stranded DNA virus that is cytotoxic to erythroid progenitor cells, causing inhibition of erythropoiesis. While maternal disease is usually mild, fetal infection can result in spontaneous abortion, aplastic anemia, nonimmune fetal hydrops, and fetal demise. This fetus had an increased NT of 3.2 mm at 11 weeks’ gestation with a normal male karyotype and microarray analysis on chorionic villi sampling, in addition to a normal fetal echocardiogram at 15 weeks’ gestation. The anatomy scan at 20 weeks’ and 1-day gestation revealed fetal ascites, pleural effusion, and increased middle cerebral artery peak systolic velocity suspicious for fetal anemia. At this time, maternal serology for parvovirus was positive for IgM and IgG. Amniocentesis, cordocentesis, and intrauterine transfusion were performed. The amniocentesis revealed elevated parvovirus B19 DNA, quantitative PCR (2,589,801 copies/mL, reference range <100 copies/mL). The patient delivered a viable male fetus at 37 weeks’ and 6-day gestation, without sequelae of the previously noted hydrops. Parvovirus B19 infection should be a consideration when evaluating increased NT and hydrops fetalis. It warrants close antepartum surveillance and possible intrauterine fetal transfusions. With prompt recognition, proper treatment, and surveillance, these patients can go on to achieve healthy term deliveries. Long-term outcomes of delivered infants require further study.

Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops

2014 ◽  
Vol 34 (11) ◽  
pp. 1023-1030 ◽  
Author(s):  
Guillaume Macé ◽  
Marine Sauvan ◽  
Vanina Castaigne ◽  
Marie-Laure Moutard ◽  
Anne Cortey ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Parvovirus B19 ◽  
Severe Anemia ◽  
Fetal Hydrops ◽  
Parvovirus B19 Infection

Expression of interleukin-6 (IL-6), signal transducer and activator of transcription-3 (STAT-3) and telomerase in choriocarcinomas

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Luciana Pietro ◽  
Fátima Bottcher-Luiz ◽  
Lício Augusto Velloso ◽  
Joseane Morari ◽  
Marcelo Nomura ◽  
...  
Keyword(s):  
Cell Transformation ◽  
First Trimester ◽  
Bewo Cell ◽  
Placental Development ◽  
Trimester Abortion ◽  
Bewo Cells ◽  
Culture Cells ◽  
Bewo Cell Line ◽  
Blastocyst Implantation ◽  
First Trimester Of Pregnancy

Abstract Blastocyst implantation and neoplastic invasion have some common properties related to tissue invasion, mediated by various cytokines. Aim To compare the expression of IL-6, STAT-3 and telomerase in material of abortions in the first trimester of pregnancy, at term placentas and in choriocarcinomas. Methods Immunohistochemical reactions were performed on formalin fixed and included in paraffin samples from 3 groups: abortions, normal at term placentas and choriocarcinomas. Western Blot and Real-Time PCR assays were performed on fresh material from BeWo cell line and in primary culture cells of normal placenta. Results Immunohistochemical reactions: IL-6 expression was moderate in the first trimester abortion samples and high in at term placentas and choriocarcinomas. STAT-3 was strongly positive in all groups. Telomerase expression was absent in normal at term placentas but was increased in BeWo cells. Conclusion IL-6 and STAT-3 are present in the invasion process of the normal placental development and they are maintained during the malignant transformation to choriocarcinoma. The intense telomerase expression observed in BeWo cells was strongly associated with the malignant phenotype, confirming it as a good marker for cell transformation and tumor progression.

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