scholarly journals Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

10.3791/52105 ◽  
2015 ◽  
Author(s):  
Klaus Zweckberger ◽  
Yang Liu ◽  
Jian Wang ◽  
Nicole Forgione ◽  
Michael G. Fehlings
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spinal Cord ◽  
Precursor Cells ◽  
Cervical Spinal Cord Injury ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Self Assembling ◽  
Cord Injury

scholarly journals Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury

2018 ◽  
Vol 9 ◽  
Author(s):  
Lennart Riemann ◽  
Alexander Younsi ◽  
Moritz Scherer ◽  
Guoli Zheng ◽  
Thomas Skutella ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spinal Cord ◽  
Precursor Cells ◽  
Cervical Spinal Cord Injury ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cord Injury

scholarly journals Treadmill training improves survival and differentiation of transplanted neural precursor cells after cervical spinal cord injury

2020 ◽  
Vol 45 ◽  
pp. 101812 ◽  
Author(s):  
Alexander Younsi ◽  
Guoli Zheng ◽  
Moritz Scherer ◽  
Lennart Riemann ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cervical Spinal Cord ◽  
Precursor Cells ◽  
Cervical Spinal Cord Injury ◽  
Treadmill Training ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cord Injury

Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury

2021 ◽  
Vol 568 ◽  
pp. 103-109
Author(s):  
Xue Chen ◽  
Xin-Yao Yin ◽  
Ya-Yu Zhao ◽  
Chen-Chun Wang ◽  
Pan Du ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
The Novel ◽  
Cord Injury ◽  
Seed Cells ◽  
Muse Cells

scholarly journals Spinal cord-derived neural precursor cells as a preventive therapy for spinal cord injury

2018 ◽  
Vol 13 (4) ◽  
pp. 1101
Author(s):  
SeyedMojtaba Hosseini ◽  
Ali Sharafkhah ◽  
SeyyedMohyeddin Ziaee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Preventive Therapy ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cord Injury

Endogenous stem cell proliferation induced by intravenous hedgehog agonist administration after contusion in the adult rat spinal cord

2009 ◽  
Vol 10 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Nicholas C. Bambakidis ◽  
Eric M. Horn ◽  
Peter Nakaji ◽  
Nicholas Theodore ◽  
Elizabeth Bless ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intravenous Administration ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord ◽  
Adult Rats ◽  
Significant Difference ◽  
Cord Injury

Object Sonic hedgehog (Shh) is a glycoprotein molecule that upregulates the transcription factor Gli1. The Shh protein plays a critical role in the proliferation of endogenous neural precursor cells when directly injected into the spinal cord after a spinal cord injury in adult rodents. Small-molecule agonists of the hedgehog (Hh) pathway were used in an attempt to reproduce these findings through intravenous administration. Methods The expression of Gli1 was measured in rat spinal cord after the intravenous administration of an Hh agonist. Ten adult rats received a moderate contusion and were treated with either an Hh agonist (10 mg/kg, intravenously) or vehicle (5 rodents per group) 1 hour and 4 days after injury. The rats were killed 5 days postinjury. Tissue samples were immediately placed in fixative. Samples were immunohistochemically stained for neural precursor cells, and these cells were counted. Results Systemic dosing with an Hh agonist significantly upregulated Gli1 expression in the spinal cord (p < 0.005). After spinal contusion, animals treated with the Hh agonist had significantly more nestin-positive neural precursor cells around the rim of the lesion cavity than in vehicle-treated controls (means ± SDs, 46.9 ± 12.9 vs 20.9 ± 8.3 cells/hpf, respectively, p < 0.005). There was no significant difference in the area of white matter injury between the groups. Conclusions An intravenous Hh agonist at doses that upregulate spinal cord Gli1 transcription also increases the population of neural precursor cells after spinal cord injury in adult rats. These data support previous findings based on injections of Shh protein directly into the spinal cord.

Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor

2004 ◽  
Vol 189 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Takao Setoguchi ◽  
Kinichi Nakashima ◽  
Takumi Takizawa ◽  
Makoto Yanagisawa ◽  
Wataru Ochiai ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cord Injury
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