Clinical Benefit of Zoledronic Acid for the Prevention of Skeletal Complications in Advanced Prostate Cancer

2005 ◽  
Vol 4 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Fred Saad
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Clinical Benefit ◽  
Advanced Prostate Cancer ◽  
Skeletal Complications

Continuing benefit of zoledronic acid for the prevention of skeletal complications in men with advanced prostate cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 4575-4575 ◽  
Author(s):  
F. Saad ◽  
D. M. Gleason ◽  
R. Murray ◽  
N. S. S. Tchekmedyian ◽  
P. Venner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Advanced Prostate Cancer ◽  
Skeletal Complications

Continuing benefit of zoledronic acid for the prevention of skeletal complications in men with advanced prostate cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 4575-4575
Author(s):  
F. Saad ◽  
D. M. Gleason ◽  
R. Murray ◽  
N. S. S. Tchekmedyian ◽  
P. Venner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Advanced Prostate Cancer ◽  
Skeletal Complications

COST-EFFECTIVENESS OF ZOLEDRONIC ACID FOR THE PREVENTION OF SKELETAL COMPLICATIONS IN PATIENTS WITH PROSTATE CANCER

2004 ◽  
Vol 171 (4) ◽  
pp. 1537-1542 ◽  
Author(s):  
SHELBY D. REED ◽  
JASMINA I. RADEVA ◽  
G. ALASTAIR GLENDENNING ◽  
FRED SAAD ◽  
KEVIN A. SCHULMAN
Keyword(s):  
Prostate Cancer ◽  
Cost Effectiveness ◽  
Zoledronic Acid ◽  
Skeletal Complications

615 Long-term efficacy and safety of zoledronic acid in men with advanced prostate cancer and bone metastases

2004 ◽  
Vol 3 (2) ◽  
pp. 156 ◽  
Author(s):  
F. Saad ◽  
D. Gleason ◽  
R. Murray ◽  
P. Venner ◽  
S. Tchekmedyian ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Advanced Prostate Cancer ◽  
Efficacy And Safety ◽  
Term Efficacy

Bisphosphonates for Treatment and Prevention of Bone Metastases

2005 ◽  
Vol 23 (32) ◽  
pp. 8219-8224 ◽  
Author(s):  
M. Dror Michaelson ◽  
Matthew R. Smith
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Cord Compression ◽  
Optimal Timing ◽  
Duration Of Treatment ◽  
Treatment And Prevention ◽  
Increased Risk ◽  
Skeletal Complications ◽  
Cancer Complications

Bone metastases are a major cause of morbidity for men with prostate cancer. Complications of bone metastases include pain, fractures, and spinal cord compression. Although they appear osteoblastic by radiographic imaging, most bone metastases are characterized by excess osteoclast number and activity. In addition, pathologic osteoclast activation is associated with increased risk of skeletal complications. Zoledronic acid, a potent inhibitor of osteoclast activity, differentiation, and survival, decreases the risk of skeletal complications in men with androgen-independent prostate cancer and bone metastases. Other bisphosphonates, including pamidronate and clodronate, seem to be ineffective in this setting. The reduction in risk of skeletal complications with zoledronic acid must be weighed against potential adverse effects. Additional studies are needed to determine the optimal timing, schedule, and duration of treatment in men with bone metastases as well as the potential role of bisphosphonates in other settings including the prevention of bone metastases.

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